Manganese Cures and Side Effects
"The classes of enzymes that have manganese cofactors are very broad and include such classes as oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases, lectins, and integrins. The reverse transcriptases of many retroviruses (though not lentiviruses such as HIV) contain manganese. The best known manganese-containing polypeptides may be arginase, the diphtheria toxin, and Mn-containing superoxide dismutase (Mn-SOD).
Mn-SOD is the type of SOD present in eukaryotic mitochondria, and also in most bacteria (this fact is in keeping with the bacterial-origin theory of mitochondria). The Mn-SOD enzyme is probably one of the most ancient, for nearly all organisms living in the presence of oxygen use it to deal with the toxic effects of superoxide, formed from the 1-electron reduction of dioxygen." (Wikipedia)
1 YEA
[YEA] 05/12/2007: Denis from Luo Dong Township, Taiwan writes: "Some years ago I had a hair mineral analysis done. In general, the profile of minerals was on the low end of the normal range. However, copper was only about 85% of the minimum considered normal and manganese was only about 50%. I have severe food allergies and apparently the inflammation is interfering with normal mineral absorption. I have always been athletic and have more or less kept up a regular schedule of aerobic exercise for the last 38 years or so. One type of exercise I have had trouble doing is dips. Beginning in my late teens, whenever I started doing dips, I would get severe bursitis and have to quit. It was not until I was in my late forties that I had this hair mineral analysis done. I went to a local chemical shop and bought the purest form (high quality lab chemicals manufactured in Japan) of Manganese Chloride I could find. I began taking small quantities, only a few tiny crystals a day. Before long, for the first time in my life, I was able to do dips without getting bursitis. Now, caution is warranted. I knew I was low in manganese. However, it is a trace mineral, and too much can cause nervous system damage. After several years, I more or less forgot about it and my shoulder joints starting getting weak again. Two falls on two separate occasions resulted in dislocating both of my shoulders within the last year. Now, I am taking a little more, about 90 mg a day in order to strengthen my shoulder joints. I also have a very weak liver, and I suspect that manganese deficiency is a big part of this as well. If you want to try manganese chloride, first make sure you have a deficiency and then, take no more than 50 mg a day of the pure manganese, i.e. you must figure the weight of the choride and water molecules attached."
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1 YEA
[YEA] 08/14/2007: Jan from USA writes: "I need to ask Ted what dosage of manganese to take per day ?? and any dangers of overdose ?? since manganese is not well known I'm kind of nervous of overdose."
Ted from Bangkok, Thailand replies: "Dear Jan:
Q: What is the dosage of manganese per day ?
A: It is often NOT taken per day.
Manganese overdose is relatively difficult if common sense principles are applied which is basically taken when it is needed only and most remedies are taken relatively infrequent, and yet, if it does work, it is taken on an "as needed" basis.
The common dose is 25 mg and taken only once for hair loss, but also the tablets, assuming it is taken in that form are quite commonly poorly absorbed if for some reason, it is taken on an empty stomach.
In event the next day hair loss reduction is noted, then it's working, the next step is to determine the exact dose, which usually means it is taken gradually and not everyday.
Some people who do take manganese noticed improvement in mood and reduction in depression, so they know how to monitor that one whenever those people are deficient. Optimum dose is not commonly pursued to avoid overdose, with the possible exception of suboptimal health.
The other issue is manganese should generally be taken in powdered, or the tablets are grounded or chewed so that the tablets which take that form with the addition of waxy substances such as manganese stearate(a wax) and calcium carboante, which prevents their absorption, also takes its toll on mineral bioavailability so the exact dose on as per label are always less if we consider how much of those gets absorbed when other waxes and fillers block them.
This has happened so often, that I lost count, this is perhaps my biggest concern with the supplements. And usually excesses or lack of it can be measured somewhat indirectly with the use of hair mineral analysis, which while it is not an exact science, is better than no information at all, especially in event of a heavy metal toxicity.
While dietary manganese level is 2 mg, most long term lack of it can result in negative levels of the body's stores for manganese, which is why in practice a single dose of 25 mg is taken just once a week, or in event of that manganese is confirmed to work, than it is taken on an "as needed basis" which can be like once a week until all conditions are gone, or in the event of a bad hair loss, it is taken for 4 days out of a week then it is stopped. It is stop because apparently the hair loss has been cured with that remedy.
The other problem about dietary manganese of 2 mg is that we are beating around the bush, how much DOES our body needs, and how much it is taken are two different things. The great divide is how well our body absorbed them which in practice, I suspect it is more closer to 10% of what is taken are absorbed, based on my optimistic projection. The older we get, the less we absorbed them so the body can end up being deficient across the board with the "essential minerals" while at the same time, being excessively loaded with free heavy metals that the body does not need.
For people with caution, natural sources of manganese are possible, but it must be understood that the level of manganese from natural sources varies, the biavailability can be limited, since manganese works best if taken alone on an empty stomach and it works synergistically with vitamin C and other problems such as destruction of mineral or mineral depletion due to processing of natural foods.
Rich manganese sources that is commonly used are soy milk, but nuts & seeds also have it. My own experience from eating nuts and seeds is the absorption to raise the manganese level is relatively very slow - like several months from those sources, while the other forms are relatively much more quicker, such as chelated amino acids of manganese, or chelated manganese. Sea salt rich in mineral is possibly another source, while the amount is quite small, its effect for a specific symptoms or sickness, won't resolve them quickly. It is therefore used when several mineral imbalances are noted that a sea salt will pull through or it is used as a supplements and the dose is fairly small which is 1/4 teaspoon of sea salt in one liter of water and can be taken often as people feel it is necessary. "
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2 WARNING!
[WARNING!] 05/14/2007: Scott from Pen Argyl, PA writes: "If you are taking any other supplments, check those and their manganese content before starting on blackstrap molasses. It may save you quite a bit in the way of anxiety and medical bills."
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[WARNING!] 01/04/2007: Scott from Pen Argyl, PA writes: "Be careful about Manganese -- it can cause symptoms of Parkinsons' Disease or Bells Palsy. 'I was taking a number of supplements that included manganese. The muscles on the right side of my face started to go slack and I was unable to use my mouth effectively. I thought I was having a stroke. Luckily I had a friend over who took me to the emergency room. I was diagnosed with Bells Palsy. It was supposed to go away within 1-2 months. It persisted for "7" months. I ran across something on the interment stating that overdosing on manganese can cause Parkinson's type symptoms. After checking the supplements I was taking I found that I was taking roughly 600 to 800 times the daily recommended allowance of this mineral. After I threw out these supplements my Bells started to clear up. If you have any similar type symptoms check what you're taking and eliminate those with manganese."
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