★★★★★
https://pubmed.ncbi.nlm.nih.gov/39886794/
Here is a very relevant quote from the literature review :
' The neuroprotective, anti-inflammatory, and antioxidant qualities of melatonin, a hormone mostly produced by the pineal gland, have drawn interest as a possible treatment option for AD. This study looks at new evidence that suggests melatonin overexpression to be a promising therapy option for AD. Melatonin levels naturally decline with age and decrease more significantly in individuals with AD, worsening neurodegenerative processes. Melatonin has therapeutic potential as it inhibits Aβ formation, prevents amyloid fibril extension through structure-dependent interactions, and protects neurons from Aβ-induced toxicity. Melatonin promotes neurogenesis, which is decreased in AD, suggesting it may treat the disease's many pathologies. The review emphasizes the importance of melatonin's mechanisms of action, including its capacity to reduce neuroinflammation, regulate mitochondrial function, scavenge free radicals, and influence apoptotic pathways. '
As you can see melatonin offers potential to fight Alzheimer's disease at many of its known activity pathways suggesting that melatonin will be very useful in many anti Alzheimer's disease regimens. Another advantage of melatonin is that it has a proven very good safety profile and with the advent of Melatonin Gel (MG) a better potential delivery method of systemic melatonin that can last approximately 24 hours whereas oral melatonin is only active for about 5 hours.
Another advantage of melatonin is that it can be very effective at ameliorating the "Sundowning" effect of agitation that comes on in the later afternoon in in many people with AD. Here is a link that gives a detailed explanation of "Sundowning".
https://www.alzheimers.org.uk/about-dementia/symptoms-and-diagnosis/symptoms/sundowning
I have seen how effective melatonin can be for sundowning and it can be a real game changer for that AD symptom alone!
Art
