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"The suspected mechanism of action of methylene blue is inhibition of the enzyme nitric oxide synthase, which ultimately prevents the smooth muscle dilation that accompanies anaphylaxis. Methylene blue may be a valuable adjunct in the treatment of anaphylaxis and other causes of refractory hypotension.'
The data suggested that in human septic shock, methylene blue increases mean arterial blood pressure through an increase in cardiac index and systemic vascular resistance.
Shock is often a syndrome caused by a systemic derangement of perfusion leading to widespread cellular hypoxia and organ dysfunction. These include cardiogenic (e.g., heart failure), obstructive (e.g., tension pneumothorax), and distributive shock. Distributive shock is characterized by loss of vasomotor tone or an overall decrease in systematic vascular resistance, and is often accompanied by an increase in cardiac output. Sepsis and anaphylaxis are the two most common etiologies of distributive shock. Also, drug-induced shock from certain medications such as calcium channel blockers may have a distributive component as well.
I used Compasslaboratory MB 0.5% solution.
