Cardiovascular Disease (CVD) and Melatonin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000067/

Here are some relevant quotes from the study :

' This pilot study demonstrated that compared to placebo, melatonin administration was associated with better outcomes in AMI patients undergoing primary percutaneous coronary intervention. '

' At 2 years of follow-up, 13 (13.8%) patients suffered the primary endpoint (3 deaths and 10 readmissions due to heart failure), 3 patients in the melatonin group and 10 in the placebo group. '

' The hypothesis-generating analysis found a relation between treatment effect and ischemia time and the authors concluded that melatonin administration within 3 h of ischemia onset reduces myocardial infarct size by approximately 40%. '

' The results of this pilot study indicate that treatment with intravenous melatonin in patients with AMI undergoing primary percutaneous coronary intervention is associated with a reduced incidence of death or readmission due to heart failure. '

This is the first study that I have seen using melatonin in people that have just had a heart attack and the results are quite impressive! The attached graph clearly shows that melatonin significantly improved longer term survival with just one dose given within 3 hours after MC. What this study doesn't show is what would have happened had the patients continued to take melatonin for the full study length of 800 days beyond the single dose given at the hospital.

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This article breaks it all down by each aspect of CVD and how melatonin interplays with each aspect and is very straightforward in its approach. Here is a link to the full article :

https://www.cureus.com/articles/47653-relationship-between-melatonin-and-cardiovascular-disease

Here is a direct quote from the article that is interesting:

>>> ' Despite contradictions between the studies the majority of data claims that melatonin is a promising supplement with hardly any adverse effects. ' <<<

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