★★★★★
I ordered the two kinds of methyl B12's and methyl folate (metafolin). 45% of the population genetically have a problem of utilizing regular B12 and folic acid and need a more available form (the methyl form). I've been on it for a couple weeks and already my body temperature has increased by one and a half degrees to normal! Hasn't been normal in years.
If one has any reaction on these, it is highly likely one has the block. I reacted strongly at first and needed to titrate very slowly.
Very briefly, methylation has to do with detox. If one's glutathione levels are low then they can no longer protect the fragile B12's from toxins, infections, stress. Oddly, at first, this can Not be corrected by increasing one's glutathione and doing so can actually make things worse (has to do with the sulfur cycle).
Families with chronic fatigue, FM, MC, crohn's, alzheimers are suspect. Also autism.