★★★★★
Sarcosine improves symptoms of schizophrenia, increases memory & develops the capacity to learn. My notes state 1-2G, however, I wrote only 1G for 3-5 weeks, then slowly add 1/4G.
Betaine crosses BBB, in treatment with mice it reduces behavioral symptoms of schizophrenia. No human trials yet, however eventually I will try.
Psilocybin, a single dose offered Rapid improvement in the levels of Anxiety, Depression. Psilocybin, a compound found in psychedelic mushrooms can affect mood & perception to “Regulate” arousal & panic responses. A single dose of one drug can ease anxiety& depression for five (5) years. Hard to read my own handwriting, however, I think you will get what I mean.
Ketamine, FDA approved for PTSD, Depression, Anxiety. 1 infusion lasts 3.5 months.
Skullcap for insomnia. L-Glutamine you have.
Yamuna Jujube, may keep Dr. away when you eat 3 daily. Calms brain, Anxiety. Jujube sounds very interesting, derived from the old jujube candies.
Schizophrenia treatment BXCL 501- reduces agitation in schizophrenia & Bipolar disorder. Dose 120 mg. A sublingual medication. Joseph
Multiple Supplements
★★★★★
Multiple Supplements
★★★★★
Just recently I started doing more research and I have found is some new research that looks fairly promising.
"Glutamate is the main excitatory neurotransmitter in the central nervous system. Dysfunction of the glutamatergic system plays an important role in the pathogenesis of schizophrenia.
Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of the affected which causes diminished autophagy which in turn results in increased neuronal cell death.
It is observed that biotinidase, which maintains biotin levels, is very sensitive to oxidative stress."
So with the above in mind, I started to research what would effect the Glutamatergic system and also the beclin-1 and also help with oxidative stress.I discovered they have been running some trials using Sarcosine and N-Acetyl Cysteine.
"Sarcosine (N-methylglycine) is a naturally occurring GlyT1 inhibitor that has been used in early clinical trials in Taiwan. Initial studies with sarcosine showed efficacy similar to - and in some cases better than - that of direct glycine/D-serine site agonists when added to first-generation or non-clozapine second-generation antipsychotics. Sarcosine also has been found to be effective for acute treatment of schizophrenia."
One study administered N-acetylcysteine, a glutathione precursor, as a potential treatment for persistent negative symptomsEncouraging clinical results were observed in this double-blind study, along with improvement in negative symptoms, and overall functioning.
To address the low levels of Beclin-1 in the hippocampus of the affected which causes diminished autophagy which in turn results in increased neuronal cell death. I found that Trehalose reduces p62/Beclin-1 ratio and increases autophagy in the frontal cortex of ICR mice, possibly by increasing Beclin-1.
"biotinidase, which maintains biotin levels, is very sensitive to oxidative stress"
To deal with the Oxidative stress I have found that Cold Pressed Krill oil and astaxanthin appear to be the best course of action I can find.
So to sum it up...
This is our new course of action:
1,000MG twice a day of Sarcosine and N-Acetyl Cysteine via Profrontal a natural product designed to support
NMDA Receptor function
1250 MG Cold Pressed Krill Oil
4 MG Astaxanthin
Trehalose ( sub-lingually ) Not sure on the dosage of the treholose yet
We where going to try CBD Oil (cannabidiol) as they had a very promising clinical trial in Germany where the CBD Oil had the same effects if not better than the typical anti-psychotic medicine without all the side effects of anti-psychotics. BUT the cost would be a minimum of $1,500 a month and only be available in states that had legalized medical marijuana. Yes, you can buy CBD Hemp oil via the mail but the quality and source is very questionable.
I will update my post going forward if we see improvement.
