Histamine aggravated levothyroxine-induced cardiomyopathy in guinea pigs.
Hu HJ, Dai DZ, Shen YM.
Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China.
AIM: To study effects of histamine on cardiomyopathy.
METHODS: Cardiomyopathy model was developed in guinea pig by i.p. levothyroxine 0.5 mg.kg-1.d-1 for 10 d. Langendroff's hearts were perfused. ECG and contractile force were recorded. Histamine (5 micrograms) was given by intra-aortic injection. Histamine content of coronary venous effluent was determined fluorometrically.
RESULTS: Attack of histamine on cardiomyopathy was severer than that in normal hearts. Tachycardia was more prominent; atrioventricular conduction block occurred earlier; decrease in coronary flow was more marked. Uptakes of histamine were 37% in the model and 19% in the normal hearts (P < 0.01).
CONCLUSION: Histamine aggravated levothyroxine-cardiomyopathy.
Levothyroxine
Generic Name: levothyroxine (LEE voe thy ROX een)
Brand names: Levothroid, Levoxyl, Synthroid, Unithroid
Zhongguo Yao Li Xue Bao. 1997 Mar;18(2):159-60
I then wondered if my symptoms got worse because of the synthroid