DHEA for vaginal atrophy: Several ladies have posted that when applied vaginally DHEA does not get into the bloodstream and acts only on local tissue.. 2.5 mg mixed with coconut oil triggered migraine consistently after 2 days' use. I infer from this that it does indeed get into the bloodstream. So beware, ladies, as whatever the benefits, the possible side effects listed on sites such as the respected Mayo Clinic can be serious and include hormone sensitive cancers.