★★★★★
About 2 years ago someone put me on to 5 Hydroxy Tryptophan or 5-HTP as a precursor to serotonin production and I decided to give it a try (the potential for weight loss was an added incentive) and I found the results somewhat hit and miss until after some research and experimentation I hit on the combination of 5-HTP (100mg) combined with Pyridoxal 5 Phosphate (15mg) (the active enzyme version of vitamin B6 and assists in the conversion of the 5-HTP to serotonin) taken first thing in the morning on an empty stomach (I avoid eating for at least half an hour). The theory from my research into taking it on an empty stomach is that this avoids the 5-htp metabolising into serotonin in the stomach before it can be absorbed into the bloodstream. Further, I have found that the active version of B6 is more effective than the common variety version (pyridoxine) because I think I struggle to metabolise the pyridoxine variety into the active enzyme and therefore have a natural B6 deficiency (probably why I don't produce enough serotonin).
I haven't had a bout of depression for over 12 months now despite the fact that I have experienced (as many others have over the past 4 months) the most stressful and extreme anxiety creating environment of my professional life.