If you are tolerating 20 mg with no issues, you likely can handle more. I take 132 mg/night.
Berberine is usually around 1500 mg per day in three divided doses, but I believe that study only used 800 mg /day.
You didn't say if you know the cause of your EPI, but vitamin D deficiency is common in EPI and if you aren't already taking higher dose vitamin D you might consider it to try to get near the top of the reference range which is 30 to 100 ng/ml. If your EPI is caused by pancreatitis, you might also consider supplements that are used for that purpose of which both berberine and melatonin are on that list.
Since you have a diagnosis of IBS-d, you may be a candidate for FMT if the IBS-d is severe enough. You can talk to your doctor about that option.
Art
EPI Remedies
Two others to consider are,
Grape Seed Proanthocyanidin Extract (GSPE) due to its highly potent antioxidant activities as well as its anti inflammatory effects :
https://pubmed.ncbi.nlm.nih.gov/11351148/
Here is a relevant quote :
' Treatment with narcotic analgesics and pancreatic enzyme supplements had failed to control their symptoms. The addition of a commercially available IH636 grape seed proanthocyanidin extract (commercially known as ActiVin) to their treatment regimen led to a reduction in the frequency and intensity of abdominal pain as well as resolution of vomiting in 1 patient. '
And Astaxanthin :
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143310/
Here is a relevant quote :
' Astaxanthin, a potent antioxidant significantly reduces oxidative stress and protects from pancreatic damage. Inhibition of PPAR-α does not block the effect of ATX in cerulein-induced AP. The antioxidant effects of astaxanthin are related to its scavenging activity and its increasing effect on antioxidant defense enzyme. Astaxanthin can be used as a valuable therapeutic approach in AP.'
It is also worth noting that vitamin D deficiency is thought to be a contributing factor to AP and CP. Making sure that your 25 OH d level is well into the reference range (30 to 100 ng/ml) would be important and your doctor should check your level so you can make it so.
I use this GSPE at the label recommended dose of 3 capsules per day:
I use this Astaxanthin at the label recommended dose of one soft gel per day :
Art
EPI Remedies
The following animal study shows that colloidal silver (CS) has a very negative impact on this parasite :
https://pubmed.ncbi.nlm.nih.gov/31610183/
Here is a relevant quote :
' The animals that received these nanoparticles showed a statistically significant decrease in the oocyst burden and number of viable oocysts in stool and a statistically significant increase in serum gamma interferon in comparison to the corresponding group receiving the standard treatment and to the infected non-treated control group. '
I think EC sells CS (AgNPs) or used to sell it. I don't see it on the home page anymore, so I'm not sure.
On a related note, Food Grade Diatomaceous Earth (FGDE) is known to be an intestinal parasite killer.
Art
EPI Remedies
EPI Remedies
EPI Remedies
EPI Remedies
EPI Remedies
My ibs-d has apparently progressed to EPI. The dr put me on creon, which is supposed to help digest fats in my diet. Any thoughts on what I could do to rejuvenate my pancreas? My symptoms are horrible diarrhea that is very fatty (think oil slick in the toilet). I've always known fats caused diarrhea, but lately it's been greasy, pale and really stinky. I really don't want to take another medicine if I can help it, especially such a pricy one. Suggestions?
EPI Remedies
