★★★★★
This new study (April, 2024) adds further confirmation to the idea that melatonin is useful for the treatment of Pulmonary Fibrosis and IPF :
https://www.sciencedirect.com/science/article/abs/pii/S0041008X24001479?via=ihub
Here is a relevant quote from the study :
' Melatonin, a hormone with antioxidant properties, has been shown to prevent EMT and reduce fibrosis in previous studies. However, the mechanism through which melatonin targets EMT to prevent pulmonary fibrosis caused by PM2.5 exposure has not been extensively discussed before. In this current study, we found that melatonin effectively prevented pulmonary fibrosis caused by prolonged exposure to PM2.5 by targeting EMT. The study demonstrated changes in cellular morphology and expression of EMT markers. Furthermore, the cell migratory potential induced by prolonged exposure to PM2.5 was greatly reduced by melatonin treatment. Finally, in vivo animal studies showed reduced EMT markers and improved pulmonary function. These findings suggest that melatonin has potential clinical use for the prevention of pulmonary fibrosis. '
Art
Lumbrokinase
★★★★★
Please look into Lumbrokinase (Earthworm extract) as a possible treatment for Pulmonary Fibrosis.
I think this treatment might help many PF patients.
The fibrinolytic enzymes like Lumbrokinase, Nattokinase and Serrapeptase/Serratiopeptidase do help with IPF/PF, but they don't work in everybody and do not get close to a level of 100% in people with IPF. The addition of the 5 supplements are likely the best shot at an optimal regimen for PF/IPF in most people.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624573/
Here is a relevant quote from the study :
' In a progressive disease such as IPF, a small improvement in scores or even stable scores may indicate that the supplements are exerting beneficial effects. A small number of subjects showed no significant improvement or a worsening of scores as compared to baseline. It is possible that a longer period of supplementation may have been required in these subjects to produce benefits. '
In this study, they used a combination supplement that contained both Nattokinase and Serrapeptase.
Art
