5 Safe & Promising Supplements for Glioblastoma

https://www.sciencedirect.com/science/article/abs/pii/S0197018621001832?via=ihub

Here is a relevant quote from the study :

' We found that BA and BX led to a remarkable reduction in U-87MG cell viability in a concentration-dependent manner. We also found that boron compounds increased the total oxidative status and MDA levels along with the SOD and CAT enzyme activities and decreased total antioxidant capacity and GSH levels in U-87MG cells without inducing DNA damage. The cytokine levels of cancer cells were also altered. We verified the selectivity of the compounds using a normal cell line, HaCaT and found an exact opposite condition after treating HaCaT cells with BA and BX. BA applications were more effective than BX on U-87MG cell line in terms of increasing MDA levels, SOD and CAT enzyme activities, and decreasing Interleukin-1α, Interleukin-6 and Tumor necrosis factor- α (TNF- α) levels.

Especially, BA application was found more favorable because of its inhibitory effect on PIK3CA, PIK3R1, PTEN and RAF1 genes. In conclusion, our analysis indicated that boron compounds may be safe and promising for effective treatment of GB. '

So based on this study, Boric Acid appears to be more effective than Borax against Glioblastoma (brain cancer) cells although both showed anti-glioblastoma activity. Importantly, both showed more activity against the cancer cells than normal healthy cells. This is a problem often seen in chemotherapy where it is toxic to the cancer cells, but also too toxic to the normal cells resulting in unhealthful outcomes.

Like borax, boric acid is very inexpensive and readily available in what would be considered bulk amounts and some people prefer it to borax because it is more refined, whereas, borax is basically unrefined. Another reason why BA may be preferred over borax is because of the salt content of borax, which would be important for people who have to limit their salt intake.
For those who take boric acid (BA), they generally take a lower dose than would be needed for borax because BA has more boron in it than borax does. Where borax is approximately 11.34% boron, BA is approximately 17.48% boron.

In any case, I thought this is important information worth sharing with the EC community because Glioblastoma has an average survival time of 12 to 15 months after being diagnosed which gives a very good idea of how ineffective the current medical treatments are for this form of cancer. So BA seems worth considering if you have glioblastoma and seems worthy of mentioning with the other two supplements I discussed in the original article at the beginning of this page.

Art

Immediately start taking LDN and don't stop. If nothing else it slows progression of cancers, possibly puts it into a remission. You can even continue your treatments while taking LDN. Call a compounding pharmacy and ask names of the doctors who prescribe LDN. Make an appointment and get a prescription ($90/mo.) Anyone who has cancer of any type must take LDN indefinitely. Get LDN, do research later, you have no time to waste. Ldnreasearch trust is your source of the info about LDN. Make sure you don't live near cell towers, antennas etc.

I read your feedback about the glioblastoma post I wrote. I will reply to each point that you made.

You said, ' This is wrong info (regardless of what studies say) and you are giving people false hope.'

You are saying the studies are wrong, but offer nothing to substantiate your claim. By saying this you are essentially saying that all scientists and researchers involved in these studies are lying about their findings. Why would they do that and why are they all conspiring together to give out false hope to everyone who has glioblastoma? If this is the case, then are all scientific researchers also lying?

You said I am giving false hope by reporting these studies. All I am doing is reporting what these studies show. How is that giving false hope? I clearly stated what I wrote in the third paragraph,

'While the two below supplements cannot cure the cancer, studies have shown that they can potentially increase survival time. One of the supplements was even shown to do so in a human study with just 20 mg/day.'

That is not giving false hope, it is stating the facts of the study by a doctor/researcher, who dedicated his life to research of cancer and how melatonin helps fight it. Dr. Lissoni has 321 studies on PubMed and was the lead researcher in the majority of those studies. He has 450 publications and his studies date back to 1982 with his last study done in 2018 and his last article done in October 2022.

I don't know how you can denigrate a person of this caliber who has dedicated his life trying to not only fight cancer, but also try to find solutions to such a deadly disease and then you essentially call him a liar. What do you base your statement on? How is all of his research just "slight of hand?

Yes, this is what you said, ' Studies like this are like a magician's "slight of hand"....they get you to look over here when the answer is actually in the other hand.'

First this statement makes no sense, because there is no current answer for glioblastoma in any hand, that is a fact. Nobody with blastoma likes it, but there currently is no treatment that is effective. Your statement is offensive to every cancer researcher out there and especially to someone like Dr. Lissoni who has given his all to fight cancer in its many forms.

You said, ' My father died of glioblastoma 30 years ago.'

I am sorry for that, but we all have to go through that as part of life. It was hard for me to deal with my parents deaths, but we do it with the hope to see them in a better place and time.

You said, ' There is nothing new in this field. '

Definitely the therapeutics of glioblastoma has not advanced much in a beneficial way.

Lastly, you said, ' Actually, there are a few things that can stop all cancers and glios.....but it's not what you point your readers to... '

Well the world is holding their breath, waiting for you to share, " a few things that can stop all cancers and glios", and please include what you are basing that statement on.

As far as what I pointed to, I pointed to studies for a form of cancer that has an average life expectancy of 12 months and if you are lucky, maybe 14 months after diagnosis. If there is no cure, then the next best thing is trying to extend life if possible. If you are given a choice to die in a year with standard therapy or to try 2 supplements with standard therapy that could potentially add time beyond a year, I think the majority of people are going to opt for plan b, or you can share just share your few things that will cure all cancers and glios, as you said.

I think I covered all of your points.

Art

That is an interesting regimen you are taking! Are you fighting cancer?

There are many molecules and supplements or alternatives that have anticancer effects. One of the characteristics that are needed for glioblastoma is the ability to cross the blood brain barrier (BBB). Ivermectin is not thought to have that capability, but mebendazole has shown that capability.

Another supplement with an excellent safety profile as well as the abilities to cross the BBB and have a negative impact on glioblastoma cells is Astaxanthin. Unfortunately studies are even more limited for it. Given the safety profile of astaxanthin, I would still consider higher dose astaxanthin if I had GBM.

It is one thing to say what you would do when you don't have GBM, but once you have confirmation from your doctor of a GBM diagnosis, I think rationale thinking goes out the window, at least temporarily, until you get past trying to wrap your head around the idea that you likely only have about a year to live.

Thank you for your feedback, Tom!

Art

The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug - PMC (nih.gov)

I recently run into a few studies that even methylene blue and borax also can do such things:

Anticancer activity of methylene blue via inhibition of heat shock protein 70 - ScienceDirect

boraxinduced-apoptosis-in-hepg2-cells-involves-p53-bcl2-and-bax.pdf (geneticsmr.org)

Boric Acid Inhibits Cell Growth in Breast and Prostate Cancer Cell Lines | SpringerLink

Some drugs and supplements for high blood sugar also seeems to be promising anti cancer agent:

metformin cancer - Google Search

gymnema sylvestre anti cancer - Google Search

Maybe you have mentioned these materials in your other articles already. I personally am taking high dose melatonin as prevention after reading some of your articles. I am also taking ivermectin, mebendazole, fenbendazole, apricot seeds, metformin and gymnema sylvestre.

Don't miss Art's new article!

https://www.earthclinic.com/cures/glioblastoma-supplements-art-solbrig.html

Thank you so much, Art!