Osteoporosis and Melatonin

Here is a quote of what the study concluded :

' Melatonin was found to reverse the inhibitory effect of TNF-α on osteogenic differentiation and inflammation in BMSCs. Taken together, these findings indicated that melatonin may have therapeutic potential to be used for the treatment of osteoporosis. '

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585202/

Here are some very relevant quotes from the review :

' Recent studies have indicated that serum melatonin levels are closely associated with the occurrence and development of osteoporosis in postmenopausal women. Exogenous melatonin could also improve bone mass and increase skeletal strength. '

' Melatonin directly affects bone remodeling by promoting osteogenesis and suppressing osteoclastogenesis. Melatonin also regulates the biological rhythm of bone tissue, which benefits its osteogenic effect. Additionally, melatonin participates in the modulation of the bone microenvironment. Melatonin attenuates the damage induced by oxidative stress and inflammation on osteoblasts and prevents osteolysis from reactive oxygen species and inflammatory factors. '

' Based on the evidence in this review, melatonin will play a more important role in the diagnosis, prevention, and treatment of postmenopausal osteoporosis. '

' Melatonin is increasingly valued by patients and clinicians due to its antioxidant and antiaging properties. In our previous study, we determined that serum melatonin levels were obviously decreased in postmenopausal women with osteoporosis (Cao et al., 2022). '

' Melatonin is a mild osteogenic drug with few complications and has the potential and prospect of being an effective drug for the treatment of osteoporosis. '

' Therefore, serum melatonin measurements might become a new diagnostic standard for the prediction of the risk of postmenopausal osteoporosis. In fact, they could replace conventional dual energy X-rays, which would reduce economic costs and improve detection efficiency. '

' Melatonin treatment positive affected the increase in bone mineral density and the improvement in body mass index (Treister-Goltzman and Peleg, 2021). However, oral estrogen could inhibit nocturnal melatonin release in postmenopausal women (Okatani et al., 2000). '

Given the above, it is becoming very clear that melatonin is of significant value when it comes to osteoporosis and given its very good safety profile when compared to the latest class of drugs for osteoporosis, Bisphosphonates, it seems like a good choice.

Here is a list of Bisphosphonates which include Fosamax, Actonel, Boniva, Reclast and Aredia .

This link is for Fosamax side effects :

https://www.drugs.com/fosamax.html#side-effects

Here is a list of side effects :

Fosamax side effects

Get emergency medical help if you have signs of an allergic reaction to Fosamax: hives; wheezing, difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Fosamax and call your doctor at once if you have:

• chest pain, new or worsening heartburn;

• difficulty or pain when swallowing;

• pain or burning under the ribs or in the back;

• severe heartburn, burning pain in your upper stomach, or coughing up blood;

• new or unusual pain in your thigh, hip or groin;

• jaw pain, numbness, or swelling;

• severe joint, bone, or muscle pain; or

• signs of low calcium levels - muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes).

Common Fosamax side effects may include:

• heartburn, upset stomach;

• stomach pain, nausea;

• diarrhea, constipation; or

• headaches; or

• bone pain, muscle or joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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