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https://www.frontiersin.org/articles/10.3389/fphar.2022.851663/full
Here is a very relevant quote from the study :
>>> ' This study confirmed that bone density positively correlates with the melatonin level in human blood. In the animal model, melatonin supplementation reverses postmenopausal osteoporosis. We explored the internal mechanism of melatonin treatment of osteoporosis. Melatonin promotes an increase in intracellular calcium ion concentrations through the STIM1/ORAI1 pathway to induce osteoblast proliferation. ' <<<
Art
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585202/
Here are some very relevant quotes from the review :
' Recent studies have indicated that serum melatonin levels are closely associated with the occurrence and development of osteoporosis in postmenopausal women. Exogenous melatonin could also improve bone mass and increase skeletal strength. '
' Melatonin directly affects bone remodeling by promoting osteogenesis and suppressing osteoclastogenesis. Melatonin also regulates the biological rhythm of bone tissue, which benefits its osteogenic effect. Additionally, melatonin participates in the modulation of the bone microenvironment. Melatonin attenuates the damage induced by oxidative stress and inflammation on osteoblasts and prevents osteolysis from reactive oxygen species and inflammatory factors. '
' Based on the evidence in this review, melatonin will play a more important role in the diagnosis, prevention, and treatment of postmenopausal osteoporosis. '
' Melatonin is increasingly valued by patients and clinicians due to its antioxidant and antiaging properties. In our previous study, we determined that serum melatonin levels were obviously decreased in postmenopausal women with osteoporosis (Cao et al., 2022). '
' Melatonin is a mild osteogenic drug with few complications and has the potential and prospect of being an effective drug for the treatment of osteoporosis. '
' Therefore, serum melatonin measurements might become a new diagnostic standard for the prediction of the risk of postmenopausal osteoporosis. In fact, they could replace conventional dual energy X-rays, which would reduce economic costs and improve detection efficiency. '
' Melatonin treatment positive affected the increase in bone mineral density and the improvement in body mass index (Treister-Goltzman and Peleg, 2021). However, oral estrogen could inhibit nocturnal melatonin release in postmenopausal women (Okatani et al., 2000). '
Given the above, it is becoming very clear that melatonin is of significant value when it comes to osteoporosis and given its very good safety profile when compared to the latest class of drugs for osteoporosis, Bisphosphonates, it seems like a good choice.
Here is a list of Bisphosphonates which include Fosamax, Actonel, Boniva, Reclast and Aredia .
This link is for Fosamax side effects :
https://www.drugs.com/fosamax.html#side-effects
Here is a list of side effects :
Fosamax side effects
Get emergency medical help if you have signs of an allergic reaction to Fosamax: hives; wheezing, difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using Fosamax and call your doctor at once if you have:
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chest pain, new or worsening heartburn;
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difficulty or pain when swallowing;
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pain or burning under the ribs or in the back;
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severe heartburn, burning pain in your upper stomach, or coughing up blood;
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new or unusual pain in your thigh, hip or groin;
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jaw pain, numbness, or swelling;
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severe joint, bone, or muscle pain; or
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signs of low calcium levels - muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes).
Common Fosamax side effects may include:
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heartburn, upset stomach;
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stomach pain, nausea;
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diarrhea, constipation; or
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headaches; or
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bone pain, muscle or joint pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Art
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I just finished reading your interesting article on melatonin. I know you can't prescribe, but could you suggest a dosage that I could begin with? Any recommendation would be helpful as I do not have medical coverage right now.
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Here is a quote of what the study concluded :
' Melatonin was found to reverse the inhibitory effect of TNF-α on osteogenic differentiation and inflammation in BMSCs. Taken together, these findings indicated that melatonin may have therapeutic potential to be used for the treatment of osteoporosis. '
Art
Melatonin Feedback
I've really appreciated your new melatonin piece. I use a tiny dose every night 1.8 which over time has improved my mood, too. I hope you don't mind me using your thread to point out i5 is low progesterone that most women suffer, not low estrogen. This is a common but crucially important mistake that needs correcting everywhere we can.
Progesterone is a precursor to estrogen and hardly ever mentioned. Look up Dr. John Lee pioneer in the study of natural progesterone. Our bodies are actually so overloaded with estrogen from what we eat and outside sources (Xeno estrogen) that it leads to varying problems like bone weakness, thyroid problems, overweight, diabetes. Our hormones are completely out of balance which obviously is disruptive to our endocrine system. I could go on but this is your post about melatonin and just wanted to point this out in the hope it will be read and picked up by the many people who are affected by it.
Thank you. Anne
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Please continue illustrating the earth clinic readers with your very interesting posts.
How are you feeling after your COVID 19 experience?
I wrote the article you are referring to and at the time that I wrote it, I was taking 106+ mg/day of melatonin. I was just making a statement about the dose I was taking and not recommending that others take such a high dose. I am now and have been taking 132 +mg/night of melatonin for about the past 9 months or so.
In the following study they used melatonin @ just 5 mg/day for patients with osteopenia, but they also used three other supplements with it, vitamin K2, Vitamin D and Strontium in the following doses :
' 5 mg melatonin, 450 mg strontium (citrate), 2000 IU vitamin D3 and 60μg vitamin K2, '
The study refers to this combination of supplements as MSDK.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310667/
Here are two relevant quotes from the study :
' MSDK treatment increased BMD in lumbar spine (4.3%) and left femoral neck (2.2%), with an upward trend for total left hip (p=0.069). MSDK increased serum P1NP levels and reduced bone turnover (CTx:P1NP). Psychometric analyses indicated that mood and sleep quality improved for the MSDK group. MSDK-exposed human mesenchymal stem cells (hMSCs) and human peripheral blood monocytes (hPBMCs) plated in transwells or layered demonstrated increases in osteoblastogenesis, decreases in osteoclastogenesis, increases in OPG (TNFRSF11B) and decreases in RANKL (TNFSF11) levels. '
' These findings provide both clinical and mechanistic support for the use of MSDK for the prevention or treatment of osteopenia, osteoporosis or other bone-related diseases. '
Also worthy of mention is that this study was a one year study and that would be a minimum study period for a disease such as osteopenia or osteoporosis because that would normally be the earliest to see measurable results.
I think all of the supplements used are very good for osteoporosis, however, in my opinion the doses were fairly modest, but seem like good starting doses. This combination of supplements proved to be effective in the study and in my opinion is part of a group of many supplements that are beneficial for osteopenia and osteoporosis.
Even the common osteoporosis prescription drug Fosamax requires 3 years to increase spinal density 6% to 8%, whereas these supplements, at modest dosing, were able to increase spinal bone mineral density 4.3% in just one year. Fosamax comes with the potential for these side effects :
https://www.drugs.com/sfx/fosamax-side-effects.html
While the study supplement combination is likely to offer other health benefits such as improved mood and sleep quality as mentioned in the study above.
As regards dosing for people taking high dose melatonin, there are suppliers offering 60 mg of melatonin per capsule such as this :
As far as a specific brand to recommend, I do not have one.
Art
Melatonin Feedback
EC is a community that is all about sharing and indexing natural health ideas to help everyone with their health issues, so your input and feedback is definitely appreciated!
Art
Melatonin Dosage for Osteopenia
Unfortunately, not being a doctor, I can not give dosing suggestions, I can only tell others what I am using and what some doctors are using or suggesting. Dr. Neel is using 1 mg of melatonin for every kilogram of body weight for his Covid -19 patients. I am using 106 mg of melatonin per night as a preventative. Dr. Shallenberger said he suggests 180 mg of melatonin in his patients and suggests over 300 mg per day for his stage 4 cancer patients.
In Cynthia's post in this thread, she cites her use of melatonin at 30 mg/day to get rid of a lingering Covid-19 cough in a week. She suggests starting low and working your way up on dosage to make sure you can tolerate higher dosing. At my current dose, I had a similar response to a cough I got from the flu that had been lingering for months and it was gone in about 3 days after starting HDM (High Dose Melatonin). I have worked my way up on dosing when I first started melatonin to make sure I could tolerate HDM similarly to what Cynthia described.
In a 2020 study, they used 10 mg of melatonin in Parkinson's Disease patients that produced modest benefits in patients.
In Manila's Doctors Hospital, they used dosages of 60 to 72 mg to treat Covid-19 patients successfully, but Filipinos are generally smaller people so their dose may be fairly close to what Dr. Neel is using for his over 1,000 Covid-19 patients.
In another post in this thread, Dana reports a study where they used just 3 mg of melatonin per night to get a positive response in COPD patients.
I always keep in mind that some people can not tolerate melatonin as reported on EC by others, but the majority of people are able to tolerate melatonin as shown in multiple studies.
Art
Melatonin Dosage for Osteopenia
What helps is natural calcium from food - no calcium supplements as these end up like concrete in heart.
K2 many studies done, and this is a must to take calcium from food and deposits in bones.
Mineral supplements without calcium.
Boron!
Why is there bone loss? Lack of Estrogen.
I know many women post menopausal doing low dose estrogen and progesterone to prevent bone loss.
Big pharma wants you to take nasty drugs. You can protect yourself with above!
Search The Calcium Lie on Vimeo.
You need minerals and estrogen.
Melatonin Dosage for Osteopenia
Melatonin Dosage for Osteopenia
Thank you for the feedback on melatonin and your sleep!
It is very good to hear that melatonin is improving your sleep so much. Good sleep is important for maintaining health and wellbeing.
Newer studies are clearly showing that melatonin has health benefits that your chiropractor may not be aware of. Ask him if he can link you to a newer study that definitively shows that melatonin interferes with your hormones. I would like to read it.
Art
Melatonin Contraindications
I have a friend who is taking lisinopril and melatonin with no problems.
This article from Drugs.com. says,
No interactions were found between lisinopril and Melatonin Time Release. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Almost anyone can have a reaction to anything and that is why I said you should have your doctor or professional healthcare provider's approval and supervision if you plan to use melatonin for anything.
I do not know what you mean by: "fix what errors"?
Melatonin Feedback
Thank you very much for the compliment and I am glad you enjoyed the melatonin series, but it has reached the end of the road with this current post!
I am glad both you and your husband are tolerating HDM and like the both of you, I am also using HDM as a preventative against many potential health issues that melatonin has shown benefit for beyond what I have written on EC. To me it is an amazing molecule in that sense.
Regarding being sick, I just updated that thread today and overall I am very happy with the outcome. There were quite a few posts today so you will have to scroll back a bit to find it.
Again, thank you, BellaPaolina for your compliment and feedback!
Art
Melatonin Studies
I was reading a book today and it mentioned melatonin being an adaptogen. How cool is that!?! I wondered what class it would be considered, now I know.
Melatonin Studies
I have never heard melatonin referred to as an adaptogen, but I guess when you consider its multitude of effects to try and return us to homeostasis, I guess that makes perfect sense. It is often described as a hormone, but even Dr. Reiter said he wasn't sure of the accuracy of that description.
I meant to ask you if your brother has any peripheral neuropathy symptoms?
How are your visits with the TCM practitioner(?) going ?
Art
Melatonin Studies
TCM is going great. Needles freak me out but I have adjusted :) He puts them head to toe on my front side concentrating on abdomen I believe more (can't confirm but have been meaning to ask). I feel really good for a few days and appetite is so much better during those days. I go 2x per week. My right side is sluggish (the needle tapping is more intense) so why we concentrate on correcting balance right to left side (blue blood/red blood) also. RBC's have gotten better on last labs. I have to say the Hemo Him is still rough stuff on my digestion even with food.
Donnie Yance's book referred to melatonin as one of the many adaptogens he considers in treatment plans. That just popped out to me and had to tell you.
Hope all is well your way!
Thank you for asking about my brother and myself.
Melatonin Studies
Melatonin Dosage for Osteopenia
Also, I am 65 and I was diagnosed with osteopenia. Again I am so sorry for responding just now. I am not real tech savvy.
God bless you!
Melatonin Dosage for Osteopenia
Strontium Citrate (SC) showed good results for osteoporosis in conjunction with several of the other supplements (melatonin, vitamin D and vitamin K2) in the study I linked to in the article. Here is a link to that study again :
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310667/
Here is a relevant quote from the RCT :
' This one-year double blind randomized control trial assessed the effects of nightly melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7; MSDK) on bone mineral density (BMD) and quality of life (QOL) in postmenopausal osteopenic women (ages 49-75). Compared to placebo, MSDK treatment increased BMD in lumbar spine (4.3%) and left femoral neck (2.2%), with an upward trend for total left hip (p=0.069). MSDK increased serum P1NP levels and reduced bone turnover (CTx:P1NP). Psychometric analyses indicated that mood and sleep quality improved for the MSDK group. MSDK-exposed human mesenchymal stem cells (hMSCs) and human peripheral blood monocytes (hPBMCs) plated in transwells or layered demonstrated increases in osteoblastogenesis, decreases in osteoclastogenesis, increases in OPG (TNFRSF11B) and decreases in RANKL (TNFSF11) levels. In transwell osteoblasts, MSDK increased pERK1/2 (MAPK1/MAPK3) and RUNX2 levels; decreased ERK5 (MAPK7); and did not affect the expression of NFκB (NFKB1) and β1integrin (ITGB1). In layered osteoblasts, MSDK also decreased expression of the metabolic proteins PPARγ (PPARG) and GLUT4 (SLC2A4). In adipose-derived human MSCs, MSDK induced osteoblastogenesis. These findings provide both clinical and mechanistic support for the use of MSDK for the prevention or treatment of osteopenia, osteoporosis or other bone-related diseases.'
My purpose for discussing multiple supplements is to look for the best effects possible to improve osteoporosis. If you do not feel comfortable with one of them, you don't have to use it. In my friend that could not do the injections for osteoporosis, her doctor approved her use of the supplements including SC.
Art
Melatonin Dosage for Osteopenia
One post says they take HDM (high dose melatonin) of 106 mg+ at night but the Options to purchase melatonin below the post, only showed 10 mg capsules. I'm just confirming that 106mg+ of Melatonin is the appropriate dose and not a typo. Also any tips for finding the best melatonin would be appreciated . Thank you very much
Melatonin Dosage for Osteopenia
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Melatonin Contraindications
