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https://www.frontiersin.org/articles/10.3389/fphar.2022.851663/full
Here is a very relevant quote from the study :
>>> ' This study confirmed that bone density positively correlates with the melatonin level in human blood. In the animal model, melatonin supplementation reverses postmenopausal osteoporosis. We explored the internal mechanism of melatonin treatment of osteoporosis. Melatonin promotes an increase in intracellular calcium ion concentrations through the STIM1/ORAI1 pathway to induce osteoblast proliferation. ' <<<
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