★★★★★
Here is a link to the actual study done about 11 months ago :
https://www.frontiersin.org/articles/10.3389/fcimb.2023.1181315/full
They are looking at three specific strains of the Desulfovibrio bacteria (DSV) :
1. D. desulfuricans
2. D. fairfieldensis
3. D. piger
The study was done in worms, which may or may not translate to humans. In any case, there are specific antibiotics that can target these bacteria as well as supplements that also target these bacteria, but to date, no human studies have been done to test this theory.
As an example of a supplement that works against these strains, inulin made from agave has a negative impact, but it has not been shown which strains of Desulfovibrio it works against as discussed in this article :
https://www.sciencedirect.com/science/article/pii/S0022316622088551?via=ihub
Here is a relevant article quote :
' Desulfovibrio were depleted 40% with agave inulin compared with control. Agave inulin tended (P < 0.07) to reduce fecal 4-methyphenol and pH. Bivariate correlations revealed a positive association between intakes of agave inulin (g/kcal) and Bifidobacterium (r = 0.41, P < 0.001). Total dietary fiber intake (total fiber plus 0, 5.0, or 7.5 g agave inulin/d) per kilocalorie was positively associated with fecal butyrate (r = 0.30, P = 0.005), tended to be positively associated with Bifidobacterium (r = 0.19, P = 0.08), and was negatively correlated with Desulfovibrio abundance (r = −0.31, P = 0.004). '
Again, no human studies to support the use of agave inulin for PD.
As far as a treatment for PD, given that the actual cause or causes of PD are still not known, there is no likely cure for the disease, only treatments to help reduce symptoms. The downside to the mainstream treatments for PD is that they can have significant side effects. The treatment that has been the mainstay for PD for about 50 years is the combination drug, Carbidopa /Levodopa also referred to as Sinemet.
One of the supplements that has shown significant anecdotal evidence against PD is vitamin B1 at higher dosing levels. Again, no human studies to support its use.
My personal opinion is that one of the best natural treatments for PD is fecal microbiome transplantation (FMT). Unfortunately, FMT is only approved for two diseases in the United States, neither of which is PD. In order to get FMT for PD, you might have to travel to China, which is much more progressive than most countries when it comes to FMT. This would be cost prohibitive for most people. FMT is already proven safe in human studies, but is still only approved for Clostridioides difficile, commonly referred to as C.diff, a bacterial infection of the gut which can be life threatening in severe cases. It is also approved for IBS in the US. In both diseases, it is normally only used when the standard treatments have failed to be effective.
Art
