Parkinson's Disease Remedies

Hi Art, thanks for sharing such amazing, wonderful and valuable knowledge about supplementing with melatonin.

A bit off topic ... but are you aware of melatonin increasing the bodies need for other nutrients such as vitamin D, etc? Thank you!

Msfmomma,

Melatonin is lowered by high dose vitamin D, but raising the melatonin level in conjunction with the vitamin D level is synergistic in terms of fighting certain virus and disease such as Covid-19 and PD. Vitamin D has shown benefit for PD in multiple studies and can act as an antioxidant also, though not nearly as potently as melatonin which can neutralize up to 10 oxygen radicals compared to other antioxidants that can reduce only one oxygen radical.

In PD, melatonin is elevated in the blood as the body's attempt to raise its total antioxidant capacity which is depleted by PD and melatonin is capable of doing that if there is enough of it, but the body is only able to raise melatonin so high and consequently the bodies own antioxidant system is not able to completely come back into the normal range as reflected in studies which show that glutathione is lower or insufficient in PD patients.

The study link in the original post shows that just 10 mg of melatonin every night is able to raise glutathione levels up as well as the total antioxidant capacity. This is a very important activity in PD as oxygen radicals and peroxynitrite are at elevated levels and both destroy dopaminergic neurons and other brain cells in the substantia nigra specifically and the brain in general.

Melatonin is a potent scavenger of peroxynitrite and oxygen radicals and an inhibitor of NADPH Oxidase which is a promoter of peroxynitrite. What this all shows is that oxidative stress, peroxynitrite and other oxidants including H202are doing a considerable amount of cellular damage and melatonin is able to ameliorate some of this damage with just 10 mg/night. At a minimum the available literature suggests that melatonin may slow disease progression as well as ameliorate some of the many symptoms of PD through its multitude of protective actions in the body including acting in a potent antiinflammatory capacity and again this is important because the excessive oxidant activity which raises inflammatory markers and levels in patients with PD.

Melatonin has also shown synergy with other antioxidants such as vitamin C, D and E and supplements such as NAC, ALA and Quercetin to name a few.

Melatonin is a unique and amazing molecule that is the most potent antioxidant in the human body!

Art

So grateful to read ideas on treating/avoiding Parkinsons! My mother had it and it is something I'll never forget! My question on melatonin is, I take one 2.5mg gummy per night, if I take anymore, I have an opposite effect and end up wide awake! I really want to increase my dosage but am afraid of the awful effect! Any ideas?

Hello, my husband's family has a history of Parkinson's disease and we have been concerned that he may have the beginnings of this condition. There is a Doctor I like to watch on you tube from Costa Rica and his name is Alonso Vega. He has been making videos(spanish) on the importance of glutathione iv infusions to detox the brain. He does indicate that in order to be effective it must be through IV as glutathione supplements don't really work. Just food for thought how glutathione may also have a positive impact to prevent parkinson's disease. We will be taking our son to their clinic for a different condition but while we are there I will also be asking about the treatment for Parkinson.

Dear Shel,

The methylene blue I used was from a fish aquarium store. It is usually 1% concentration. Ted encourages a dilution to 0.1%. When I first gave it to my father with the amazing results, I gave it with sodium ascorbate. It really worked to increase his energy and initiation of action. He is still taking it and it still helps. Other supplements have also helped him a great deal, like transdermal magnesium oil. This stuff has changed his life very much for the better. It has helped a great deal in reducing stiffness. What has harmed my father is bulk magnesium citrate powder from ____.com. I ordered many bulk supplements from ___ ___. I was told to give to my father "the more the better" of magnesium citrate. I did. But what I have learned, nearly too late, is that the white powder that was labeled magnesium citrate does not have the solubility characteristics and other typical characteristics of magnesium citrate at all. It has the characteristics of possibly calcium carbonate. I can pay $300.00 to have it tested at an analytical lab, but I am not able to pay for that at this time. I will do it later. The main thing is that be sure to learn from my mistake. It caused a stroke in my father. The lesson is to buy from a reputable bulk supplement suppler who actually tests the supplements that come from China. Also I think it would be prudent for us to learn to test our own purchases even if crudely by checking for the known properties of each substance, like ph and solubility. ____, the owner of ___ ____, told me that neither he nor his supplier out of Georgia test the bulk supplements they receive from China and then sell to us.

So keep up the methylene blue because it may be very helpful to you. Ted told me that it also may build up in the body's system somewhat over time. So you will need to work with the dose and be sure to take it with sodium ascorbate. It seems to be something needed together with the methylene blue. Also if you add the methylene blue to sodium ascorbate in water, the blue color disappears.

I hope this is helpful to you. I'll pass on some words given to me by a young lady who observed me working with my father. Don't give up. Never give up.

Jane

Also if you add the methylene blue to sodium ascorbate in water, the blue color disappears. How much of this do you mix???

Hi John...I have been using Methylene Blue(MB) plus Vit C for a while now.

I bought the 1% MB at a hardware shop in the aquatics section. Then I converted the 1% MB to 0.1% MB by adding 1 X part by volume of MB to a dropper bottle, then I added 9 parts by volume of water as well. I just use a simple bottle cap for this -- where 1 part by volume equals one cap full. This will give you 0.1% MB. I put this mixture into a suitable bottle with a dropper top.

When I need it, I take one full glass of water with 2 grms Ascorbic Acid completely crushed and dissolved in it and add just one or two drops of the 0.1% MB to it. I take this twice a day if I need the energy or if I feel a cold or flu coming one. Gives you alot of energy and significantly boosts the immune system.

How is the Methylene blue administered? Orally?

Please, tell me in measures of ounces how many methylene blue and vitamin C . I need to use for 85 years father that Parkinson and also what I can give to him so he feel thirsty and water. If you can explain what is happening inside the body when he will take it

Dear Jane:

The methylene blue works, however, continual use of low dose is very helpful. However if it is discontinued, at least in the beginning may weaken the energy level, but further dose will allow the person to recover. Methylene blue is considered a super antioxidant for the mitochrondria. The best that I have seen so far. The brain is the highest metabolic rate in the body and hence is helpful with methylene blue since it increases energy level to normal levels through mitochrondria support. Taurine supplements and some potassium bicarbonate with baking soda are also helpful and supportive to this remedy too.

It's often best used as dose I have mentioned. I liked it so much I have since added methylene blue to my Emergency Aid kit as posted previously, although it remains I still needed some tweaking. Low levels of brain metabolism is what I believe to be causing the Parkinson's disease, and I have found the methylene blue to be helpful.

Thank you for the feedback!

Ted

Hi Ted! I just accidently sent my last message before I was ready. I have so much to learn! I have not yet seen your Emergency Aid kit. How much Taurine supplements should I give? I have baking soda and I'm not exactly sure if I have potassium bicarbonate. I have potassium supplements. Is potassium bicarbonate a household product?

Thank you! Thank you! For your help.

Dear Jane:

A taurine supplements dose averages about 1000 mg taken twice a day, with plenty of water, such as 1/2 glass of water. The taurine has a protective effect on the brain. As to alkalization, usually the preferred remedy.

As to your questions of potassium bicarbonate or potassium citrate or tripotassium citrate. These aren't usually available in most household items, but maybe available or found in electrolyte drinks formulation or found in certain potassium supplements found. When taking potassium, a baking soda is always taken. The dose for potassium is small, usually 1/8 or 1/4 teaspoon once a day while a baking soda may require just 1/2 teaspoon and a low dose to help stabilize the pH. Over the long term, usually about a week, an alkaline blood leads for the brain to recover faster too. Often it's the acidity of the brain that cause some degeneration of the brain and alkalinity provides protection. The rationale is a simple one: brain is a highly metabolic organ and hence is most acidic and needs something to reduce the excess acidity coming from carbon dioxide when the brain cells metabolise. This is a mild remedy.

A carnosine 500 mg x 2 is also seen to be helpful too, but aspartame and all artificial sugar must be avoided as those are most damaging to the brain. There are some unbelievers who think aspartame is safe, to which I always suggest to check for presence of blood methanol and formaldehyde after ingestion and it's always present in order to settle the aspartame controversy. Aspartame are also found in chewing gums and is also not helpful.

Ted

Hi Jane, can you tell me how your father is getting on with the methylene blue? Is it proving helpful. A relative of mine has just been diagnosed with Parkinson's. As yet they only have tremors in the hands and I would love to get something that prevents it getting any worse, or at least slows down its progression. Any updates would be appreciated. Thanks, Mary.

Dear Mary from Northern Ireland,Yes my father is getting along well and the Parkinson's symptoms are definitely diminished since taking the methelyne blue regularly. I am very encouraged about this and I have specific reason to suspect that the Parkinson's is at least partially fungal related in my father. He is also taking the alkaline drink with sodium carbonate, bicarbonate of soda, potassium citrate, taurine, carnosine. The alkaline drink two and sometimes three times a day is noticeably helpful as well. He has sleep apnea which is problematic at times. The alkaline drink seems to help with this some as does sleeping on his side and not on his back. I would hate to be without any of these things because I have noticed increased mental focus for my dad and increased energy. At first I believe he was taking too much methylene blue, a drop of 1% solution three times daily. He is now taking a drop or two of 0.1% two to three times daily depending on our schedules. The higher concentration may have temporarily caused a tremor that wasn't there before. His symptoms did not initiate with the tremor, but with the mask like face and a shuffling gate. Now his face is like his old self with his smile and usual expressions. He has his sense of humor and his personality again. Also I believe that magnesium is helping him very much too.Not magnesium aspartate! Also I have since learned that our eating food with msg may have correlated with a little setback he had. So now we are much more careful to avoid all msg and excitotoxins that are sometimes in mineral supplements. He takes carbidopa/levidopa three times daily as well.

Jane, You should have your father's vitamin D level checked too:

Low Vitamin D Level Tied to Parkinson's Study: Vitamin D Insufficiency Often Accompanies Parkinson's Disease
By Miranda Hitti

http://www.webmd.com/parkinsons-disease/news/20081013/low-vitamin-d-level-tied-to-parkinsons

WebMD Health NewsReviewed by Louise Chang, MDOct. 13, 2008 -- Parkinson's disease patients may be particularly likely to have low blood levels of vitamin D.

Researchers report that news in the Archives of Neurology.

They studied 100 Parkinson's disease patients, 100 Alzheimer's disease patients, and 100 healthy adults of the same age as the Parkinson's and Alzheimer's patients.

Participants provided blood samples, which showed vitamin D insufficiency in 55% of the Parkinson's disease patients, compared to 41% of the Alzheimer's patients and 36% of the healthy participants.

Vitamin D deficiency, in which people have even less vitamin D than people who have vitamin D insufficiency, was also more common among the Parkinson's patients (23%), compared to the Alzheimer's patients (16%) and the healthy participants (10%).

The findings held regardless of people's age, gender, and presence or absence of an Alzheimer's-related mutation in the APOE gene.

The study was a snapshot in time -- it doesn't prove that low levels of vitamin D cause Parkinson's disease or that taking vitamin D would help prevent Parkinson's.

But those possibilities should be studied, note the researchers, who included Emory University's Marian Evatt, MD, MS.

Parkinson's and fungus: I was reading with great interest the posts regarding Methylene Blue. I'll give it a go. However more of interest was the talk of fungus. Oddly enough, right after getting toenail fungus came Parkinson's. I have always felt that there was a connection. My opinion is that because Parkinson's is usually diagnosed in aged patients, toenail fungus was viewed as a common old age condition and never considered as a possible connection to the Parkinson's. So, if the fungus or it's byproducts are involved, that would explain why an anti-fungus med would have an effect. I'd sure like to hear more about this.

Hi Deirdre and EC!

The below link regarding Alzheimer's is interesting and there is a Parkinson's link included in the info. The fungal theory is a part of this and so much more. My Dad's Parkinson's symptoms became most evident after my mother flooded the bathtub a few times, years ago, and they dried out the carpet more than once. So I think fungus is a huge aspect of our problems here. Also as Ted says and as the article suggests, the mycotoxins are the byproduct of the fungus and may be more problem causing than the fungus itself. Apparently the mycotoxins are implicated in cancer and many neurodegenerative diseases. I think there are a multitude of factors but most are interrelated. Now that I have learned a few things about this I feel like I don't know anything at all. Its very humbling to me to try to find remedies and test what works and what doesn't. Also there seems to be so much misinformation to sift through and then try to learn what works for us as individuals.

I have tried a bit of heavy metal chelation on myself only to cause tinnitus that I can hardly get rid of. Like Sherlock Holmes I'm trying different things, observing and looking for a clue to the remedy for me as well as for my parents individually. Its scary because now I know I have so many neurotoxins, based on the tinnitus that began after chelating, and I just don't have the best plan right now to rid of it. I have tried a lot of supplements to stop it.

Jane, How is your dad doing with the MB? May I ask some basic questions? How old is he? How old was he when his first symptoms appeared? What dosing and schedule does he follow with the MB?

Hello Rick,

Just a quick answer to a few of your questions and comments. My Dad is 85. He began having symptoms at approximately 79 or so. He probably had symptoms earlier than that, but I did not see him all that often during that time and also the Parkinson's symptoms began insidiously.

We are not so perfect with the MB dosing. I try to give at least three doses per day. I also try to make sure he has sodium ascorbate to go along with it for at least two of the doses. I would like to be more consistent giving more frequent low doses of the MB and we are working on that.

Since my father had a stroke in November of 2008 and the early Spring of 2009, this has been a big setback. The stroke this Spring was the worst. He still has a great deal of recovery to accomplish, but he continues to improve. He is very mentally alert and aware of everything going on. He can still give advice and communicate well. He cannot walk. He needs assistance eating but he often is independent in eating. These problems are a result of the stroke. We have been eliminating and reducing offending foods and supplements as we observe problems. I am near certain that my father will not have another stroke. One of the biggest helps for him is magnesium oil applied all over his body. This has helped him very much and I learned a lesson about neglecting the magnesium oil. He will get stiff and harder to transfer when without the magnesium oil (I make ours from magnesium chloride flakes sold to saltwater fish aquarium hobbyists).

My father is not taking any prescription medicines to speak of now. We stopped the carbidopa/levodopa because he began to have mild hallucinations and we stopped it. He has only improved since stopping that medicine.

Jane,Is there a reason why sodium ascorbate should be taken with the meth blue? Would another form of vitamin C not be better when stroke is a possibility? And could you describe the alkaline drink your father is taking-- exact amounts etc?

Thanks,
Abigail"

Dear A from Toronto,

I learned from Ted that the sodium ascorbate is in a form more appropriate for the body since ascorbic acid would be a lower ph and our body is more optimal at a ph of about 7. Actually you could probably get a better answer from Ted because I am just learning about these things.

I have seen a published drug study regarding using the vitamin c with methylene blue. I believe it was in regard to treating malaria. At any rate it appears that vitamin c is needed. At least there should be vitamin c circulating in the body when taking methylene blue. I don't think its necessary to take vitamin c every time one takes methylene blue.

As to the stroke issue, I just don't know much about that. What I have read is that it is the chlorides that are so harmful. You know, table salt. So a good sea salt is something that you may want to get and avoid the table salt that is refined and not natural. Sodium chloride is in the processed foods as well. Apparently sea salt, like Celtic sea salt, is very good for us and even fights infections. It also increases thirst and so then we drink more water which is good for us.

Another comment about stroke. I have learned that excess calcium circulating is one sure cause of stroke. The misinformation about taking calcium is not been helpful to us at all. Also I gave my father mega doses of a magnesium citrate product that we since learned was not even magnesium at all or at least had a large component of calcium in it. We have now learned to make magnesium oil with the magnesium flakes sold to salt water fish hobbyists. I rub it on my Dad's skin and it goes through the skin into the body and relaxes his muscles and also helps to put the calcium in its place and out of the blood stream which greatly reduces his chance of having another stroke.

The alkaline drink is something we take about once per day, sometimes twice and now sometimes not at all. Everyone's needs are different and sometimes I am not that compliant. I guess its because my Dad is getting better and so now I'm not that scared. The alkaline drink we take is in a small cup with a small amount of water. We follow this drink with a glass of water. It is 1/8 tsp of sodium carbonate dissolved, then add 1/8 tsp baking soda dissolved, then add 1/8 to 1/4 tsp potassium citrate dissolved. So that's it. I still recommend inquiring of Ted because I learned this from him. The basic thing is to check urine ph and I believe it is supposed to be a 7. You may find other posts to verify all of this. It will not be in the methylene blue thread though.

Another way to alkalinize is to drink lemon water. Just don't use chlorinated water.

I hope this helps.

Jane

Hi Jane,

You have mentioned that you make your own magnesium oil from magnesium chloride. I would like to know as to how do you make and how do you use it for stiff joints/muscles.

Thanks
Baldev

Dear Baldev,

When I learned about transdermal magnesium I went out and found a salt water aquarium hobby store and looked around. I had a conversation with the owner and asked him about the magnesium and all the supplements added to the aquariums. Apparently these hobbyists are very knowledgeable about the chemicals added to the aquariums because the fish and corals are expensive and one wrong move could kill them all. Anyway I asked the man for a sample of magnesium flakes and he gave it to me. I went home and made a solution by boiling some filtered water and made a 50% solution. I rubbed it into the skin and so that's how I got started. Now I have ordered my own magnesium flakes. The shipping is expensive and so it makes the end product more expensive than I would like. Since I believe it has saved my father's life after the accidental mega doses of calcium I cannot complain though.

I am now making a solution closer to 60-65%. We have very fair skin here. Sometimes it stings a little if we have a cut or something. But its worth it. You can make the solution weak or strong. At about 70% solution I've noticed that some of the magnesium falls out of solution and so I think 70% is a bit over maximum

Our family had some purchased natural magnesium oil already before I made my own. At first I just didn't know how to use it or that I needed to put a whole lot on my father at first. I wanted to make my own for some reason. What I have learned since is that you can use too much. So you have to watch yourself. After my Dad was saturated, then we backed down a bit. The signs of too much for my Dad were that he had a few pre atrial contractions. He had never had heart arrhythmia before. So all we had to do was back off a bit and now he is doing so great the doctors are very surprised. He always has a beautiful normal sinus rhythm and his heart rate and blood pressure are just perfect. Now we need to get his brain completely healed.

Another thing that I read, I think Ted said this, that the magnesium oil from the ocean has calcium in it. I had not thought of that before. I intend to stay away from calcium the best I can since I believe that too much of it caused my Dad's stroke and contributed to his stiffness. I think calcium is in the water here too as we have hard water and when I boil it there is a white powdery film on the bottom of the tea kettle.

I am thankful to a man named George Eby who set me straight regarding the magnesium supplement that I was giving my Dad. I emailed George after reading his website and he didn't really have time to reply at the time, but he did give me a strong warning to stop the magnesium because I told him it wasn't soluble in water. He told me that it was not magnesium citrate or it would be soluble. I am extremely grateful to that man. He has an interesting website too and discussed a great deal regarding how he cured himself of depression using magnesium. Also he recommended a book by Mark Sircus called Transdermal Magnesium which I bought and its very good.

I hope this helps you.

Jane

If its starting to look like the trigger for Parkinsons is a fungus, and Methylene blue use kills the fungus over time.. Wouldnt a high dose of B vitamins be required to build the brain cells back up again after the initial onset has been stopped?.. I mean, just using the Methylene blue might stop anymore progression of the disease.. But you are still left with the subsequent debilitations... I know from past nursing experience that the brain will respond quite quickly but still need the right nutrients as in the case of dementia patient. The Dementia was quite advanced (third stage of syphlis).. It totally mimicked Alzhiemers and was picked up with a wasermans test.... But was completly cured after a course of antibiotics and B complex injections. The patient left the geriatric ward smiling and thanking everybody, he picked it up in Palastine during the second world war.. Makes you wonder how many more might have missed the correct test?

Can anyone who has been using the Methylene Blue update us on your progress?

Have you had to change your protocol over time? Have your symptoms of DP been continually diminished?

Updates appreciated. Thanks.

Ted,

Can you please respond to the long term effect on patients taking Methylene Blue, H202 and Vit C. Whats the optimal dosage . My mom has PD and she got depressed last yr after my uncle died and also had a bad fall which affected her C2. She is completely bed bound ad the biggest issue we have is daytime sleepiness.

Just started giving her good vit. Starting on a vit formula with calcium /vit D for nite - hoping it will improve the quality of sleep.

Also giving her NAC- she is still on part tube feed.

PLEASE HELP with the dosage. I remember I gave this to my mom years ago, during the intial years. Then they moved away from here and somehow it go stopped completely.

I have read about this but have not gotten any yet. I will check into it more. I am not very knowledgeable about all the possible supplements that will help him, but I am slowly learning. My time is very divided and I wish I had more time to delve into learning more. One thing is we have tried supplements and observe for benefits or any negative side effects. This is how we have been adding and taking away supplements to best meet his needs as we learn.

It appears to me that the cause of my father's symptoms are toxins in his body and now brain injury from the strokes. Also most probably fungus is involved. He had pesticide exposure and we have more reasons to believe his problems began with toxic exposure, probably multiple toxins.

Thanks for your post. I appreciate any comments and helpful information.

I have taken Macuna since 2009. I find it to be very valuable. Have never taken a specific PD pharmaceutical, and won't. The side effects are far too dramatic. Macuna has no negative side effects.

In reply to Ron (New Mexico),

That is great that the MP is working for you! Can you give details on your entire protocol (dose & timing) and what benefits you are getting? Thank you!

Art

I was interested in reading about people taking Mucuna (velvet bean) for Parkinsons. Would love to know what doses others take. I have been taking it for about 18 months as I want to avoid prescription drugs.

Hi Emma,

The dosing for Mucuna Pruriens(MP), like Levodopa, is very individualized and will vary considerably from person to person. People wonder what is the attraction of MP over prescription Levodopa/Carbidopa since MP has as one of its main components, Levodopa and the truth is that some people just prefer what they consider a more natural approach of using a natural plant over a prescription drug. While it is true that they both contain Levodopa, but Levodopa on its own can increase oxidative stress in the brain which can then increase neuroinflammation and in the long run this is likely to be counterproductive for people with Parkinson's (PwP) as they are already suffering with elevated oxidative stress levels and elevated neuroinflammation which have been shown to increase disease progression.

What MP has that makes it possibly more effective than Levodopa is other useful components which have shown the ability to lower oxidative stress and neuroinflammation. These other components include quercetin, Betulinic Acid, Ursolic Acid, CoQ-10, NADH and more which have shown the ability to lower oxidative stress and neuroinflammation. This is very important for PwP and Levodopa alone has none of these other attributes that MP has.

You may be wondering what MP can do compared to levodopa in PwP that is different. In PwP studies, MP can significantly reduce onset of action significantly which is important because many PwP complain that it can take an hour or more to take effect while MP takes effect significantly faster probably due to the other active components in it as mentioned above. That effect alone may make it worth it for some PwP to consider MP. Another benefit of MP over levodopa alone is increased "on time" of 21.9%! Levodopa is a single component prescription drug and can not offer these other benefits of MP! Increased "on time", equates to decreased "off time and what PwP wouldn't want that?

One study went so far as to suggest that MP, "protects or prevents the progression of the disease".

On a related note, I will be posting about this in more detail soon, here on EC! I am of the opinion that a combination of levodopa and MP maybe the best of both worlds as multiple Levodopa products also contain Carbidopa or Benserazide to control levodopa breakdown before it reaches the brain and I believe it also helps prevent conversion of levodopa to dopamine outside of the brain and this is very important because dopamine can not cross the blood brain barrier.

Art

Your post is from 2017. How are you doing now? Was the Mucuna Prurien beneficial for over the 5 years you been on it?

Jason,

You are replying to a post that is 5 years old in which case the original writer is not likely to reply. I will try and give you a little information to give you and idea about what is involved with the use of MP.

Regarding MP, in a couple of studies it has shown to have similar to slightly better effects than prescription levodopa products. It also does not cause the oxidative stress that levodopa has shown in studies to cause. It also offers other health benefits. Those are some of the positives.

On the negative side, it takes huge doses of pure MP to equate to Sinemet dosing and such huge doses have the potential to cause stomach upset and are hard to take.

Manufacturers are aware of this issue and decided to make "extract versions" of MP so that a smaller, more tolerable dose can be taken. But even with extract versions, it still requires relatively large doses. One problem with the most potent extract versions is that they are essentially levodopa with little if any of the beneficial components that pure MP contains. So you don't really get any of the beneficial effects of the MP.

What some PwP do, is combine a lesser dose of Sinemet or other levodopa based drug with an extract version of MP in order to get the added benefits associated with the use of MP in conjunction with the stability and uniformity of a drug like Sinemet or Madopar. I think this is what you will find once you have done research into MP in all of its many forms.

A common form of MP extract that some PwP find benefit with is Dopa Boost :

https://www.amazon.com/Designs-Health-DopaBoost-Dopamine-Pruriens/dp/B004LKVDR4/ref=sr_1_5?crid=2W9DQKYEEG87Y&keywords=dopa+boost+supplement&qid=1657052407&sprefix=dopa+boost,aps,213&sr=8-5

This is an interesting product that combines MP extract with other supplements that have shown benefit for PwP. It also uses EGCG, the active component from green tea to act similarly to the Carbidopa component of the combination drug Sinemet which is comprised of Carbidopa and Levodopa. It also contains other PD useful supplements such as N Acetyl L-Tyrosine, vitamin B6 and Quercetin.

PwP use Dopa Boost with a levodopa drug like Sinemet. Sounds simple, right? Not that simple though because, in general, neurologists and movement disorder specialist are not going to be familiar with MP or a product such as Dopa Boost, and this means they will not be able to help you determine an ideal dose combination between your prescription levodopa and your non prescription MP product.

This means you will be on your own to figure out the most effective dosing of both products for you. Even if you find someone that has already done the leg work to figure out through trial and error what their best dosing schedule is for the combination of MP extract and levodopa drug is, you will only be able to use their information as a rough guideline and you will still have to fine tune your dose to meet your specific needs through trial and error.

On this general subject of alternative PD remedies, there are several that I am aware of that have shown varying degrees of benefit in improving quality of life, but like levodopa drug products, there is usually a need for trial and error testing or a learning curve to figure out the best dosing schedule for you.

In PD, there are no cures on the horizon, only various alternatives to try and improve your quality of life. If you are interested in any of those other options, I can offer you some information regarding them if I am familiar with your choice.

Art

My Dad is 94 years old. No one can believe it. He still lives independently, drives his own car and his memory is fantastic. He has eaten eggs all his life, so I don't worry about it. His cholesterol is 170. He also eats a lot of fast food so I don't know what his secret is.

I think you will find that "Yams" according to the latest research.. will go a long way in repairing the brain after a stroke.. Google "Yams and stroke".. I'm sure it will be what you are looking for.

Dear Jane -- Four years have passed since your query about protein for your dad with PD, but in case you're still working with your dad, I recommend you use the Oil-Protein Diet of Dr. Johanna Budwig, as given on the Healing Cancer Naturally site. Other sites have interesting comments about the Budwig diet, but the Healing Cancer Naturally site has the most accurate info as presented by Dr. Budwig. Dr. Budwig states that the oil-protein diet increases oxygen in the system. Her program has reversed MS. Lest you be concerned about the use of cottage cheese when Parkinson's patients are advised to avoid dairy products, Dr. Budwig said that the dairy-ness of the cottage cheese or quark and the fat of the flaxseed oil are both transmuted to form a highly absorbable and effective, water soluble substance when combined in the manner she prescribed.

Best wishes, Judy

I greatly thank you for your reply.

Selinas

Hi Mery,

Here is a link to the actual study done about 11 months ago :

https://www.frontiersin.org/articles/10.3389/fcimb.2023.1181315/full

They are looking at three specific strains of the Desulfovibrio bacteria (DSV) :

1. D. desulfuricans

2. D. fairfieldensis

3. D. piger

The study was done in worms, which may or may not translate to humans. In any case, there are specific antibiotics that can target these bacteria as well as supplements that also target these bacteria, but to date, no human studies have been done to test this theory.

As an example of a supplement that works against these strains, inulin made from agave has a negative impact, but it has not been shown which strains of Desulfovibrio it works against as discussed in this article :

https://www.sciencedirect.com/science/article/pii/S0022316622088551?via=ihub

Here is a relevant article quote :

' Desulfovibrio were depleted 40% with agave inulin compared with control. Agave inulin tended (P < 0.07) to reduce fecal 4-methyphenol and pH. Bivariate correlations revealed a positive association between intakes of agave inulin (g/kcal) and Bifidobacterium (r = 0.41, P < 0.001). Total dietary fiber intake (total fiber plus 0, 5.0, or 7.5 g agave inulin/d) per kilocalorie was positively associated with fecal butyrate (r = 0.30, P = 0.005), tended to be positively associated with Bifidobacterium (r = 0.19, P = 0.08), and was negatively correlated with Desulfovibrio abundance (r = −0.31, P = 0.004). '

Again, no human studies to support the use of agave inulin for PD.

As far as a treatment for PD, given that the actual cause or causes of PD are still not known, there is no likely cure for the disease, only treatments to help reduce symptoms. The downside to the mainstream treatments for PD is that they can have significant side effects. The treatment that has been the mainstay for PD for about 50 years is the combination drug, Carbidopa /Levodopa also referred to as Sinemet.

One of the supplements that has shown significant anecdotal evidence against PD is vitamin B1 at higher dosing levels. Again, no human studies to support its use.

My personal opinion is that one of the best natural treatments for PD is fecal microbiome transplantation (FMT). Unfortunately, FMT is only approved for two diseases in the United States, neither of which is PD. In order to get FMT for PD, you might have to travel to China, which is much more progressive than most countries when it comes to FMT. This would be cost prohibitive for most people. FMT is already proven safe in human studies, but is still only approved for Clostridioides difficile, commonly referred to as C.diff, a bacterial infection of the gut which can be life threatening in severe cases. It is also approved for IBS in the US. In both diseases, it is normally only used when the standard treatments have failed to be effective.

Art

hello Mery.....have you thought to read up on Methylene Blue?

cheers and good luck

Here is the cure for PD as per Dr Ardis. If I had PD, I would definitely try this.

https://www.brighteon.com/8920f5f9-2c7a-4d4f-a2e4-1b26b338bb52

As Doug Kaufmann of 'Know The Cause' says, think fungus first.

Similarities between Parkinsons and ALS have been found. There is a copper binding issue, combined with oxidative stress. This should hopefully give us ideas on how to treat this eg: copper chelation, or chelated copper, and a whole spectrum of anti-oxidants and anti-oxidant minerals.

Do we need more copper, ie. chelated copper?, or less copper, ie copper chelation? Or maybe a combination of the two? It sounds like there is a deficiency but I fear that if we get it wrong it could make it worse.

“We have pinpointed a protein abnormality known as the ‘SOD1 fingerprint' in regions of neuronal loss in the Parkinson's disease brain, ” said Associate Professor Kay Double who led the research published in Acta Neuropathologica.

“We believe this loss of neurons results from a combination of oxidative stress and a regional deficiency in copper, both of which occur specifically in vulnerable regions of the Parkinson's disease brain.”

Source: http://sydney.edu.au/news-opinion/news/2017/05/22/discovery-may-offer-hope-to-parkinsons-disease-patients.html

OK this is important - if ALS is similar to Parkinson's then hopefully this treatment may work there too. This study found that in rats a copper chelator dramatically improved their health.

Source: http://www.alzforum.org/news/research-news/copper-rescue-als-mice

"As reported in the January 27 Neurobiology of Disease online, the researchers treated the mice with CuATSM, a reddish copper chelator that can carry the metal into the brain and spinal cord. There, the theory goes, the chelator releases Cu ions to the Cu/Zn superoxide dismutase 1, an enzyme that causes a rare familial form of ALS when mutated and tends to aggregate when it's missing its copper. .."

"Beckman's group was studying why those mSOD1xCCS mice fell so ill when researchers from the University of Melbourne who worked with CuATSM visited his lab. The scientists decided to try the compound in one double transgenic mouse, which was unable to stand and near the end of its short lifespan.

"The researchers dissolved CuATSM in dimethyl sulfoxide and dribbled in onto the pup's neck, where it was quickly absorbed by the skin. A few hours later, the mouse was up and moving."