★★★★★
The only side effect I have experienced is a change in my sleep pattern, waking every morning around 4:00-5:00 am with difficulty going back to sleep. I'm going to try stopping the nighttime dose and try taking the second dose after lunch to see if that resolves the problem. Also, I am allergic to sulfa drugs but have not experienced any skin related side effects with MSM. While it is a possibility that resolution of my pain is coincidental, I'm not willing to give it up in order to find out. If my pain returns while on MSM, then I'll know. I'll keep you posted.