Pernicious Anemia
★★★★★
I had an aunt I never knew who died at age 4 of pernicious anemia. Her family discovered their are a myriad of levels of B-12 that are found. You can have a tendency to low levels of B-12 even if you do not have pernicious anemia. Most people know that their levels drop off as they age as well.
(USA)
08/18/2021
I heard that if you have PA (pernicious anemia), you can still show normal blood levels but will show deficient on micronutrient testing because it can be circulating but not absorbing.
(MD)
11/05/2021
★★★★★
I have pernicious anemia and will have to have B12 shots for the rest of my life. B12 is the only vitamin that requires a cofactor in order for your body to absorb it. The cofactor is called intrinsic factor. Intrinsic factor is a protein secreted by the stomach that joins vitamin B-12 in the stomach and moves it through the small intestine to be absorbed by your bloodstream. Without intrinsic factor, vitamin B-12 can't be absorbed and leaves your body as waste. An inability to make intrinsic factor can be caused by - endocrine-related autoimmune disorders, such as diabetes or thyroid disease, surgery to your stomach or small intestine, abnormal bacterial growth in your small intestine, Crohn's disease or celiac disease, use of PPIs, old age.
I have tried all kinds of oral supplementation with limited success. I find I need an IM shot every three weeks to feel good.
Side Effects
★★★★★
(Gainesville, Florida)
09/16/2022
Debbie, research the MTHFR gene. Many people have problems with this "methylation" gene. I cannot take Methylcobalamine, which is the most common form of B12. After doing 23&Me I discovered this and now take a different form of cobalamine - hydro/adenocobalamine. I'm betting that this might be your problem. If I was you, I'd try a different form of B12. And absolutely don't buy Folinic acid. If you need to supplement this, only buy FOLATE! Lots of info on the internet regarding this. I have to buy the hydro/adeno form on line, I've never found it in my health food store!
(Kansas City, MO)
09/14/2023
It's possible to be an allergic reaction to yeast. Most vitamins are attached to yeast. Look to see if the bottle says it is yeast free. If it does not say this then it is likely in it. A quick Google search of yeast free B vitamins can lead you to one. Per Naturopath, Donald Lepore that wrote, The Ultimate Healing Guide, the antidote to a yeast allergy is Lysine and Zinc taken for 2 to 3 weeks. I know this is an old post, but maybe one day it could be useful to someone. That is my hope and prayer. God Bless Earth Clinic!
