I was diagnosed with Rheumatoid Arthritis and started using MSM to see if it will help with the chronic inflammation. I started with 1/4 teaspoon, and worked up over 2x months to 1 teaspoon after breakfast. Unfortunately I have started feeling extremely tired, my blood pressure has become erratic, and I am experiencing heart palpitations 2 to 3x per day! It has been the only change to my normal routine for the last few months.These are apparently known side effects... I did see a slight improvement in inflammation levels though, but with these side effects it is not worth it for me.