i also had a horrible reaction from taking msm. My whole body broke out in hives/rash. I never go to the doctor and prefer to treat myself naturally but it spread from head to toe and I couldn't Take it anymore. My skin was burning I had to go to the emergency room. The doctor said it was the worst case of hives he's ever seen. He gave me an extremely high does of prednisone. Which got rid of the hives but damaged my adrenals so 3 years later I'm still healing my body from the damage of the prednisone.
Hives
I have learned something interesting with MSM. I took the NOW brand for 30 days to help with Lupus. It was working great w/no side effects other than insomnia, which stopped when I cut the dosage down from 4000 mg daily to 20000 mg daily. (take it first thing in the morning) After finishing that bottle, a friend offered me a bottle that she was not going to take. It was a different brand than I had taken previously. Within 2 days, I had hives & swelling up my arms & a severe headache. I talked to the owwner of a Health Food Store in town & she said some MSM products are not as pure as others. This particular brand had 345 mg of sulfur in it. The reaction I had was to the sulfur, not the MSM. I stopped it & the rash & headache went away. I am back to taking the NOW brand with no problems. Make sure you buy your MSM at a reputable dealer, not just anywhere. Talk to the salesperson & be sure it is pure MSM.