After taking 2-3 grams for almost 3 years, however, it riddled me with imbalances and complications that I have yet to recover from. initially I started passing kidney stones- not realizing the MSM could contribute to this. After reading of a few similar cases online, I stopped taking the MSM and had a brutish withdrawal period.
I broke out in full hives on my back, fever, etc. after the withdrawal, all of my original symptoms returned, but with a twist. Over time I became similarly sensitive to most anti-inflammatory herbs/nutrients. I can't even take fish oil without having reactions. My kidneys behave irregularly, I have cardiovascular involvement, and more recently significant adrenal dysfunction. I suspect I imbalanced something nutritionally from taking the sulphuric, but i've had little to no luck finding a combination of nutrients to restore the balance. Please use caution with MSM, and even if you find it to help you. PLEASE take regular breaks when using it. Do not stay on it long-term. It's been over a decade since I stopped, and I'm not certain whether I'll ever get my life back completely.