Nattokinase, an enzyme from fermented soybeans, is widely recognized for its cardiovascular benefits, especially in improving blood circulation. However, it’s important to be aware of potential side effects, particularly related to blood clotting and interactions with medications.
What is Nattokinase?
Nattokinase is known for breaking down blood clots, which may reduce the risk of heart disease and stroke. However, as it is derived from fermented soybeans, individuals with soy allergies should be cautious.
Potential Liver Side Effects
The liver is crucial for processing and detoxifying substances, including nattokinase. While generally safe when used correctly, concerns exist that nattokinase's effect on blood clotting could impact liver function, particularly in those with existing liver disorders.
Key Considerations:
- Liver Enzyme Elevations: Nattokinase may cause changes in liver enzyme levels, which could indicate stress or damage to liver cells.
- Impact on Hemostasis: Given the liver’s role in producing clotting factors, nattokinase could potentially affect liver-related hemostasis, especially in those with liver disease.
Symptoms to Watch For:
Be alert to symptoms like fatigue, weakness, abdominal pain, jaundice, and dark urine. If these occur, seek medical advice promptly.
Conclusion: Individuals with liver disorders should use nattokinase cautiously and consult their healthcare provider.
Nattokinase and Blood Clotting
Decreased Blood Clotting and Increased Bleeding Risks
Nattokinase can reduce blood clotting, raising the risk of bruising and bleeding, especially when taken with medications like aspirin, ibuprofen, or other blood thinners. This combination may lead to excessive bleeding.1,2
Worsening of Bleeding Disorders
Due to its blood-thinning properties, nattokinase may worsen bleeding disorders. It should be used cautiously, particularly for those undergoing surgery, as it could increase bleeding risks during and after the procedure.3
Interactions with Blood-Thinning Medications
Nattokinase poses a significant bleeding risk when combined with blood-thinning drugs. For instance, a patient required repeat valve replacement surgery after substituting warfarin with nattokinase. Another case involved internal bleeding resulting in death in an elderly woman using nattokinase for an irregular heartbeat.4
Common Side Effects
The consumption of nattokinase may lead to several side effects, especially when taken in inappropriate doses. These include:
- Gastrointestinal Issues: Reports of bloating, gas, and upset stomach are common.
- Allergic Reactions: Being derived from soy, nattokinase can trigger allergic responses in sensitive individuals.
- Heightened Bleeding Risk: Its blood-thinning properties can increase bleeding, particularly for those with bleeding disorders or on anticoagulant drugs.
- Lowered Blood Pressure: It may cause a drop in blood pressure, which concerns those on blood pressure medication or with naturally low levels.
- Dizziness and Light-headedness: These symptoms might occur, especially at high doses or in sensitive users.
- Muscle Pain and Tenderness: Unexplained muscle discomfort has been reported.
- Supplement Interactions: Nattokinase can interact with other blood-thinning supplements, amplifying their effects.
- Liver Function Impact: High doses might affect liver function, requiring monitoring in individuals with liver conditions.
Special Precautions for Specific Groups
Certain groups need to exercise extra caution:
- Pregnant and Breastfeeding Women: The effects of nattokinase during pregnancy and breastfeeding are not well-studied, necessitating caution.
- Pre and Post Surgery: Due to its blood-thinning effects, nattokinase should be discontinued prior to any surgical procedures to prevent excessive bleeding.
Conclusion
The potential side effects of nattokinase underscore the importance of proceeding with caution when considering nattokinase supplements, particularly for individuals with pre-existing health conditions or those on medication. It is always advisable to consult with a healthcare professional before starting any new supplement regimen.
Related Links:
Health Benefits of Nattokinase: Evidence-Based Findings
High-Dose Nattokinase: A Game-Changer for Atherosclerosis
