Vitamin D Toxicity

Hi Dany,

You didn't say if this is a 25 OH d test or not. This is the standard test for vitamin d level. There are other forms of vitamin d that you can test for. The 25 OH d test has a reference range of 30 - 100 ng/ml.

You didn't say if the 240 number is ng/ml or nmol/l. If it is ng/ml that is really high. If it is nmol/l that is in range, albeit near the top of the range.

You also didn't mention any medications your husband is taking.

Some prescription medication that are not vitamin D based, can cause vitamin d levels to increase. One such type of medication, is a heart medication, digoxin and another is thiazide diuretics with both generally used for heart issues.

Until they are able to resolve the high vitamin D level he should drastically reduce calcium intake from supplements and food.

Art

A proper Vitamin D levels evaluation is always done by looking at 3 blood markers: serum calcium, D25 and PTH (parathyroid hormone) especially when one of the markers is out of the normal range. It is useless to have just D25 test done unless it is in the normal range.

Also Serum levels of 25-hydroxyvitamin D (25(OH)D) are used to establish an individual's vitamin D active status vs. how much is stored in tissues and organs. in other words how much is available right now to be metabolised from your blood.

Calcitrol or D1.25 shows, in simplified terms, how much was metabolised from your blood.

It is possible to have high D25 and normal or low D1.25 which warrant more investigation.

So before trying to lower D25 you need to see the whole picture and it starts with getting 4 blood makers test done.

From one of the EC posts:

“Biology is almost never as simple as "low" or "high" on a lab value. Your body always has a reason for the adaptations you're looking at in the form of blood biomarkers and this is the art of listening to what your body is trying to tell you.

Micronutrient manipulation as a whole is a game that needs to be treated with care because there are feedback loops for everything in physiology.

Supplement protocols prescribed without proper analysis create way more questions than they do answers.”

You need to know the basics about vitamin D metabolism before making an educated decision about how to proceed with your husband's elevated serum D levels. I will try to simplify it.

Vitamin D 101

The major source of vitamin D is the skin synthesis, contributing to more than 90% of vitamin D blood serum concentration.

Vitamin D can also be taken by diet, from fortified dairy products and fish oils.

Vitamin D3 enters the circulation and is transported to the liver, where it is converted to 25-hydroxyvitamin D (25(OH)D), a form thought to be biologically inactive, but which is widely regarded as the best indicator of vitamin D status.

In the kidney, 25(OH)D is metabolized to 1,25[OH]2D (calcitriol), which is the biologically active form of vitamin D.

Vitamin D plays a key role in serum calcium homeostasis. The main function of 1,25(OH)2D3 is to increase calcium absorption from the intestine, through interaction with vitamin D receptor (VDR).

The effects of vitamin D are not limited to the maintenance of calcium homeostasis. 1,25[OH]2D regulates multiple cellular processes, with effects on immune system, cardiovascular function, and interplay with other hormones.

The association between parathyroid hormone (PTH) and vitamin D may be an important determinant of bone remodeling, mainly in the elderly. A negative and significant correlation was found between PTH and 25(OH)D levels. Individuals with low vitamin D levels were those who had higher values of PTH, while individuals with high values of vitamin D showed low values of PTH.

I am one who has D25 in the upper high range, normal D1.25, normal serum calcium and normal PTH, and VDR Taq polymorphism, both copies( from my 23andme report). I do take D3 10,000iu+boron+full spectrum vitamin K once a week.

Your husband's case is different and rather mysterious. Please get Ca serum, PTH, D25 and D1.25 tests done. It is a very important starting point in the investigation.

Dany7330 in St Augustine FL,

My own experience with vitamin D has been nothing but positive. With minor exceptions to the contrary, my own serum 25-hydroxy vitamin D level has been between 149 and 750 ng/mL ever since 10/10/15 when I started testing it. On the positive side, while I have been on vitamin D at these relatively high levels, I did not have to do anything else, but during my sleep I have successfully healed at least 10 health issues I have always had, I have always wanted to heal, but had been too embarrassed to talk about. And no, there has been no negative side.

Dany, you are, or seem to be, primarily motivated by fear.

As opposed to fear, should not you base your decisions on reason, logic, science and experience?

Dany, you are not making any sense.

Serum 25-hydroxy vitamin D is measured as nanograms per milliliter (ng/mL).

You did not say what your unit of measurement was.

But if you meant to say it was a serum 25-hydroxy vitamin D medical lab test of 240 ng/mL, then this 240 ng/mL test result, in itself, is no proof of your husband's so called vitamin D toxicity.

No, it is no proof of toxicity, unless he is also experiencing all or most of the symptoms of vitamin D toxicity, such as decreased appetite, nausea, vomiting, constipation, dehydration, polydipsia, frequent urination, confusion, lethargy, fatigue, muscle weakness, bone pain, AND kidney stones.

Further, why do you think this 240 ng/mL is too high? If it was me, I would NEVER rely on Big Pharma-trained experts. No, they are NOT on your side when they recommending that this serum 25-hydroxy vitamin D level should be between 20 and 40 ng/mL, or between 30 and 50 ng/mL.

FYI, Big Pharma is not on your side, and no, they are not pulling for you. About 99% of the time they work AGAINST you. They want you to be sick, and the sicker you are, the happier they are.

They oppose higher vitamin D intakes, and higher serum 25-hydroxy vitamin D levels, A) because such measures can significantly reduce the burden of human disease, B) because therefore they would reduce income and profit from treating disease, C) because they could not care less that healthcare in the U.S. is costing increasingly more and more, and when it is already at 20% of the US Gross National Product. View http://www.orthomolecular.org/resources/omns/v14n22.shtml

Dany, may I suggest you start focusing on the benefits, and start talking positively about vitamin D.

I hope this will help you, or somebody!

I LOVE vitamin D3.

The idea of vitamin D toxicity is likely to come up every single day. However, in my experience, there has been NEVER any vitamin D toxicity, if I took only 50,000 IU, or less, vitamin D3 per day.

Further, in my experience, the biggest issue I had is the never-ending stream of FEAR messages by Big Pharma, and by the so called doctors of Big Pharma, and by allopathic doctors and pill pushers who were trained by Big Pharma.

In other words, the only thing we need to fear are the FEAR MESSAGES THEMSELVES.

My serum 25-hydroxy vitamin D has been between 149 and 750 ng/mL ever since 10/10/15 when I started testing it.

There has been NO negative side to this, except for the above-mentioned fear messages.

However, on the positive side, at these relatively high serum levels, I had to go to neither doctors nor hospitals, I had to pay no money. I just had to rely on myself. In my own house, during my regular 8-hour sleep cycles that cost me neither money nor time, I successfully healed at least 10 health issues that I have always had, I have always wanted to heal, but no one knew how to heal.

Sorry about the lack of details; here we are talking about 10+ health issues that I was and always have been too embarrassed to talk about.

I hope this will help somebody!

I found out I have Vita D deficiency so started with the recommended dosage of 500 IU…the following year, I was still under par! I asked healthy minded friends for advice since my Internist said start taking 1000IU. Some told me 2000-5000! Wow! I started to take 2K and added VitaK. The following year, perfect levels thanks to my friends. My doctor could not encourage Vita K because there were no literature/studies to support it. This was 5 years ago. Mind blowing what medicine has become or perhaps more people are taking more control of their health. I am!

darkgohan,

You are correct, cholecalciferol is used as a poison for mice and rats and can be poisonous for some animals, however, it is quite healthful for humans as thousands of studies confirm.

Art

Don't throw the baby out with the bathwater.

Vitamin D (also referred to as “calciferol”) is obtained from sun exposure, foods, and supplements. Dietary supplements can contain vitamins D2 or D3. Vitamin D2 is manufactured using UV irradiation of ergosterol in yeast, and vitamin D3 is typically produced with irradiation of 7-dehydrocholesterol from lanolin obtained from the wool of sheep. An animal-free version of vitamin D3 sourced from lichen is also available.

Cholecalciferol (vitamin D3) is in a class of medications called vitamin D analogs.