I found that taking 4000mg of buffered VitC powder robbed my body of magnesium. Maybe because of the calcium in the buffered form. High dosage of VitC has also been reported to cause cystitus, contribute to kidney stones & to kill off intestinal flora (acidophillus). I have tried taking ascorbic acid with some added bicarb but still find it irritates my system over 1000mg a day. I am now switching to fulvic acid, a strong anitoxidant, recommended by Ted, I'll keep you posted.