Cold Sores
Natural Remedies

Top Natural Remedies for Cold Sores (Fever Blisters)

| Modified on Mar 23, 2025
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Cold Sore Natural Remedies

Cold sores, also known as fever blisters, are small, painful blisters that commonly appear around the mouth, caused by the herpes simplex virus (HSV). Though there is no permanent cure for HSV, many natural remedies offer quick relief, reduce pain, and speed healing.

What Are Cold Sores?

Cold sores are fluid-filled blisters that typically appear on or around the lips. They often break open, leaving behind crusty, uncomfortable patches. Before cold sores form, many individuals experience itching, burning, or tingling sensations at the affected site. Additional symptoms can include fever, sore throat, and swollen lymph nodes. These sores result from infection by herpes simplex virus types 1 or 2.

Effective Natural Remedies for Cold Sores

Vitamin C

Vitamin C boosts immunity, reduces inflammation, and promotes rapid healing. Taking vitamin C supplements (500-1,000 mg daily) or applying crushed vitamin C tablets topically to the sore can significantly shorten recovery time.

L-Lysine

This essential amino acid helps inhibit HSV growth and replication. Oral L-lysine supplements (1,000 mg daily) or topical lysine ointments are commonly used to prevent and heal cold sores quickly.

Myrrh Oil

Myrrh oil provides pain relief and helps eliminate infections. Apply diluted myrrh oil directly to cold sores to soothe irritation and accelerate healing.

Licorice Root

Licorice contains glycyrrhizic acid, known for its antiviral properties against HSV. Apply licorice powder mixed with water directly to the sore or drink licorice tea regularly for immune support and symptom relief.

Tea Tree Oil

Tea tree oil has powerful antiviral and antiseptic benefits. Dilute a few drops in a carrier oil, such as coconut oil, and gently apply to cold sores several times daily for faster recovery.

Peppermint Oil

Peppermint oil contains menthol, which has antiviral and soothing properties. Applying diluted peppermint oil to cold sores reduces pain, swelling, and irritation.

Lemon Balm (Melissa officinalis)

Lemon balm is widely recognized for its antiviral activity against HSV. Using lemon balm cream or balm regularly on affected areas can promote faster healing and help prevent recurrent outbreaks.

Aloe Vera Gel

Aloe vera soothes inflamed skin and accelerates healing due to its anti-inflammatory and hydrating properties. Apply pure aloe vera gel directly to cold sores for comfort and rapid recovery.

Ice Packs or Cold Compresses

Applying ice or cold compresses helps reduce redness, swelling, and discomfort immediately. Apply for 10 minutes every few hours as needed during an outbreak.

Acetone (Most Popular Earth Clinic Remedy)

Though unconventional, some Earth Clinic readers have reported success using acetone (found in nail polish remover) to dry out cold sores quickly. Use cautiously by applying a tiny amount directly to the blister with a cotton swab, avoiding surrounding skin. Due to potential skin irritation, acetone should be used sparingly and with care.

Dietary and Lifestyle Tips for Preventing Cold Sores

  • Healthy Diet: Eat foods rich in immune-boosting vitamins C and E, such as oranges, berries, spinach, nuts, and seeds.
  • Limit Arginine-Rich Foods: Foods high in arginine (nuts, chocolate, and certain grains) may trigger outbreaks. Balancing with lysine-rich foods or supplements can help.
  • Stress Management: Manage stress through mindfulness practices, yoga, or exercise to reduce outbreak frequency.
  • Sun Protection: UV exposure can trigger cold sores. Regularly use SPF-containing lip balms or wear hats when outdoors.

Conclusion

Although cold sores can be painful and persistent, numerous effective natural remedies exist to manage outbreaks and provide quick relief. By employing treatments such as lysine, tea tree oil, vitamin C, and dietary adjustments, you can reduce symptoms, shorten healing time, and lessen recurrence.

Continue reading below to learn how Earth Clinic readers successfully treated their cold sores naturally, and share your own remedies and experiences with our community!

Related Links:

Effective Natural Treatments for Genital Herpes Relief
Genital HPV Remedies


The comments below reflect the personal experiences and opinions of readers and do not represent medical advice or the views of this website. The information shared has not been evaluated by the FDA and is not intended to diagnose, treat, or prevent any disease or health condition. Always consult a qualified healthcare professional for medical concerns.

Acetone

73 User Reviews
5 star (64) 
  88%
4 star (1) 
  1%
3 star (1) 
  1%
1 star (7) 
  10%

Posted by KK (Cyprus) on 02/18/2025
★★★★★

Acetone works...but cautiously

Been dealing with this regularly for 30 years.. ended up with acetone dabbed on with earbuds.

Initially kept it on until the burns. Now I'm not sure if a lot of the scabbing that follows is due to the coldsore healing itself, or actual acetone burns.

Will keep using it. Maybe cautiously to avoid damage to surrounding areas, which may actually take longer to heal.


Acetone
Posted by earth is a pancake (chiraq, illinois.) on 09/09/2023
★★★★★

When I read about cold sores and acetone - I thought these people had lost their minds!! ... but this last time I had a bad case sold sore, two locations on lower lip about 5-6 bumps / bulbs, 3-4 of them were getting oversized, I looked horrible - and hurt like a mofo.

I used a q-tip to dip in a home depot purchased acetone container and applied throughout the day starting in the afternoon. Without any exaggeration, and with outmost sincerity, it worked for me. By the end of the day 10 pm or so - the size of the bumps/bulbs decreased to about 25% from the large size of that same morning. I could not believe it. I asked my roommate, just to make sure I was not losing my mind and going blind...

By the next morning, the bumps decreased more in size, and a small scabs started to appear - signaling the healing process has begun... I only applied once or twice the second day.

Don't ingest the powerful acetone, careful breathing in the fumes - I held my breath as much as possible, sealed my lips / mouth while applying with q tip soaked. Acetone evaporates very quickly, so application time is short.. Think I applied about 10 times from afternoon til midnight the first day.

Hope this helps!

Replied by V
(US)
11/04/2023
★★★★☆

Be Careful with Acetone!

Acetone is so powerful it will take the paint right off your car!

You are using it to kill the virus, this shouldn't take more than 1 day, once the virus is dead, meaning the cold sores stop growing and developing, you need to stop using acetone, it is used to kill the virus, not to heal the cold sore, the healing process happens naturally, the more you leave it alone the quicker it will heal.


Acetone
Posted by Whathadhappendedwas (Florida) on 08/28/2023
★★★★★

Acetone is the best remedy I've tried. I get the big swollen lip. Others have said to keep it on for five minutes. However, I kept it on for a min or so at a time. I did it about 20 times the first day.

My lip went down after a couple hours. I then poked the blister with a needle and got the fluid out. Next day it crusted over. Did the acetone all day again but maybe fewer times. Third day was just a scab. Did the acetone a few more times just in case. Now I'm just waiting for the scab to come off. I'm on the fourth day. It usually takes a week before it scabs over. I guess I'll be doing this from now on.


Acetone
Posted by Sweetpeasal (Duarte, CA) on 10/25/2022
★★★★★

I have suffered with cold sores my whole life. After spending a day out in the sun, I could feel my lip starting to swell (you know the feeling). I frantically looked online to see if there was some new remedy out there. I discovered this site and saw so many good reviews about acetone I figured I'd give it a try. (I used to use BHT and lysine but that ceased to work for me.)

Miracle of miracles, the acetone worked! Several times of the day, I would press a q-tip dipped in 100% acetone onto the area until it stung and then removed it. The cold sore never even got to the tingle phase. By day two my lip was slightly swollen but only about a third of what it normally would have been. By day three it was 10% swollen with a simple scab that could be covered with lipstick. No blisters even. Unbelievable. A week later, the small scab is still there, but the sore is clearly receding to nothing.

Where has this been my whole life?! The acetone must just kill the virus! Thank you all for sharing your experience with this amazing remedy! So helpful.


Acetone
Posted by naturalremedies101 (orlando, fl ) on 08/11/2022
★★★★★

My bottom lip was tingling all day. At the end of the day around 6pm, I looked in a zoom-in mirror and could see the horrendous 3 bumps forming. I immediately began applying acetone. I did this for 30 seconds-1 min at a time up every 20-30 minutes up until I went to bed around 10pm. I worked the next day and could still see the bumps, but they did not pop or grow. I went ahead and applied and applied nail polish remover in the morning before going to work and once in the afternoon. When I got home, I applied it again until I went to sleep multiple times. I kept a cotton pad with acetone on until it burned too much. On day 3, there was no longer a coldsore forming! I can't believe this actually worked :)

Replied by beverly
(USA)
10/29/2023

Acetone is not the safest chemical in the world so I would use a q tip so as to target the sore better rather than a cotton ball.

acetonefaq.pdf (delaware.gov)


Acetone
Posted by Gemma (Lancashire) on 07/17/2022
★★★☆☆

Last summer I had a beast of a cold sore. It was 6 in one!! I hadn't had one in about 15 years so it was very weird. Probably from vaccine shedding from other people.
For some reason I didn't think to check on here until about day 5. I tried acetone but the skin was already broken and it made it 10 times worse and left a scar too.

I think acetone must be used at the first signs and would be very effective but not once the skin has broken.


Acetone
Posted by GILLIAN (CA) on 07/10/2022
★★★★★

I haven't gotten cold sore breakouts very often but have had them since I was a child. I've even gone years without an outbreak. When I would get one it would be mild and I'd combat it with Lysine and oil of oregenal both orally and topically. Usually they wouldn't even get to a blister with this treatment. However, I recently had a really large one come out on my bottom lip and it took forever to come down and heal. What a pain! The area is still slightly raw and sensitive. Over the long weekend of the 4th of July I got a lot of sun and didn't drink enough water, drank alcohol and got totally dehydrated. I felt my lip burning. I woke up with 3 huge ones on my bottom lip coming up into blisters!!!

Panicking I scoured the internet and saw Cheri's post from 2021. I tried it and put acetone on each one with a q-tip for about 20 seconds each and 1 DAY LATER they had all scabbed over!!

This would have been at least a week or more without this remedy! Thank you!!


Acetone
Posted by Cheri S. (Wellington, Florida) on 03/18/2021
★★★★★

My husband had his first cold sore at 42 years old. Neither of us even knew what it was at first. He is very tough when it comes to pain and this thing was excruciating for him. I found this suggestion on Earth Clinic, thank God. He said there was a huge relief with the very first application of acetone. He applied it with a cotton ball only 4- 5 times a day (yes, it burns, but definitely worth it). He is on day 3 now and it is significantly smaller, scabbed over, and he has almost no pain or swelling on his lip. This would have been a miserable 2 week experience if it weren't for you all posting your effective treatments. Thank you Earth Clinic!!

Replied by Sarab
(CA)
12/26/2021

Does acetone make them stay away? Just wondering because I use selenium (selenomethionine) and I don't get cold sores any more. I take 1 200mcg capsule a day although I started by taking 2 200mcg capsules a day for about 10 months.


Acetone
Posted by Jennifer (San Francisco) on 11/24/2020
★★★★★

Editor's Choice

Acetone for cold sores works. I also have used ice directly early on for a few hours off and on and that helps too.

However, the MOST important thing you can do to PREVENT cold sores is to NEVER consume ANY artificial sweeteners, which all contain aspartame, including almost any type of gum these days, diet sodas, diet drinks of ANY form, etc, as the aspartame WAKES the virus and activates cold sores. I have not had a cold sore in many years as a result of avoiding aspartame. Hope this helps someone.

Replied by Carolyne
(Washington)
12/15/2024
★★★★★

It's not just the aspartame. I started totally avoiding aspartame and ALL artificial sweeteners years ago, (I never drink sodas either) and I still get a cold sore, every time I get a runny nose-- a cold, the flu (which is RARE), or allergies and Im blowing/wiping my nose a lot!! So I think I need to take Lysine. When they do start to come on-- I SWEAR by the acetone and/or ICE!! Apply the ice cube till it hurts! let it rest a while and do it again, repeat often as soon as you feel that tingle. The virus can't take the cold and it goes away without scabbing...


Acetone
Posted by Craig (Albany, Oregon) on 10/17/2018
★★★★★

Wow! Another satisfied acetone customer. I wish everything worked so well.


Acetone
Posted by Jerome (New York) on 07/04/2018 9 posts
★★★★★

Another YEA for acetone for cold sores. I've gotten cold sores since I was a child, sometimes so deep it looked like someone put out a cigarette on my lip. Now I soak a cotton ball with acetone and press it to the cold sore for 20 seconds and after 2 or 3 applications the cold sore is on its way out. Every time.

Such a brilliant remedy, so cheap and SO much more effective than any expensive cream or Valtrex.


Acetone
Posted by Firm Believer (Nyc) on 12/21/2017
★★★★★

Absolutely, positively and without fail works 100% of the time

I'm 42 and I've gotten cold sores my whole life. Like all of you, I too have tried everything I could get my hands on including Dr. prescribed meds. Nothing. Ice seems to chill them out for a bit - but they always came back with a vengeance. I found that acetone works 100% of the time. 100%. I honestly don't care what any naysayer says. It's really that good. If you catch it at the tingle stage, then it stops there. If you catch it at the blister stage, the blisters immediately go down and your at the scab stage. Even that goes quicker. This is the closest thing to a medical miracle that I've experienced. The folks who suffer from this virus would understand that statement. I keep a little bottle of acetone in my home, my car, at work and in my luggage.


Acetone
Posted by Jordan D (Georgetown, Tx) on 12/13/2017
★★★★★

Read about this little home remedy yesterday after noticing a cluster of cold sores pop up on my lip when I woke up yesterday morning. Some of the reviews were good and some bad. I decided in a panic and with my wedding only 2 days away that it was worth a shot to try. Not big on the home remedies, but I have been getting cold sores since I was 5 years old (now 26), I have used any and all cold sore medicines, creams, tablets, you name it! None of which have been even close to successful! Last night before bed I held a cotton ball with fingernail polish remover over the nasty cluster of sores on my lip for about 6 minutes. The original post had advised leaving the cotton ball with the polish remover on the affected area for 30 minutes... YES 30 MINUTES. (Not sure how I feel about that one.) I noticed after the 6 minutes that the color of my lip was getting darker and out of fear for it bruising I went ahead and removed it. Immediately I noticed a difference in the affected area. It looked so much better! After wards I cleaned the affected area with hydrogen peroxide on another cotton ball and went to bed. I woke up this morning and to my surprise the clusters were no longer filled with that nasty liquid, they already had a nice scab on them ( the scab was almost the same color as my lips, as it did not look dark or irritated) By lunch time today everything is back to its original color, the scabs are almost completely gone, and the cluster is no longer noticeable unless I stand very close to the mirror. I am definitely forever in favor of this little remedy! Pretty surprised that such a simple solution works after spending TONS of money on medicines for it for 21 years! OH also...after using the nail polish remover BUT before using the hydrogen peroxide I gently cleaned the affected area with my fingers using luke warm tap water and antibacterial hand soap.

Good luck!!!


Acetone
Posted by Kcarey (Dublin, Ireland) on 02/09/2017
★★★★★

Nail varnish remover (acetone) on cotton wool held on cold sore for 10 mins a few times a day.

I cannot overemphasize how much this works; I currently have a very big very sore collection of cold sores & I tried nail varnish remover (as I read it somewhere else) & I could not believe how much it helped within an hour! It sounds drastic & it does sting a lot but the pain is over quickly & cold sore is drastically improved after 1 go!

I've tried everything in the past; taking lysine (cold sores still appeared), zovirax on first tingle (actually think moistening it made it come out not disappear), dabbing with alcohol (helps a v small bit), doing a lot of different stress management techniques to avoid triggers (sleep, exercise, eating well) all to no avail; the nail varnish remover is the only thing where I've actually seen a difference.

One thing I will say about prevention that works is not to let your lips get chapped; most of the times I get a cold sore its after my lips are v dry and chapped; they crack & then out pops a cold score.

I hope it helps someone else.


Acetone
Posted by Concerned (Georgia ) on 01/12/2016
★★★★★

I have suffered from cold sores ever since I was in elementary school. I am currently 20 years old. I usually get cold sores once a year. But this past year (2015), I got two of them. To top that off, I got one at the beginning of the new year. These are the WORST. I have tried nearly everything. This past time I had a cold sore, I read on the internet that nail polish remover really works. And man was that right! I caught mine before it got too bad.

I put the acetone on it once every hour of the day. Hold it for 20 seconds, IT WILL BURN! But it works. The next morning, my cold sore was almost gone. It wasn't even noticeable! I continued the process of applying acetone every hour of the day until it was gone.

It also helps to take the vitamin L-lysine. I also drink plenty of milk when I have cold sores, because milk also contains lysine.

I hope this was helpful!

Replied by Andie
(Oregon)
01/18/2017

Tried it. didn't work!!! Very disappointed... Made it spread. So mad!



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