4 New Remedies for CKD: Baking Soda, Fruit, Melatonin, Fish Oil

I was hoping you would see that, Peter!

Art

Art, give you update on my wife's gout, week one doctor prescribed 20mg 5 days prednisone to stop the pain, but it came back week 2 another prednisone treatment. Our family doctor came back this week 3 and prescribed similar (6,5,4,3 2,1) taper off version.

The pain was so bad at the week one I had to gave her 2 treatments of naproxen and I did not want to do that because of her kidney issue. She was crying thru out the night. That is when my friend 's sister, she is a doctor wrote the prescription. I thank you for your great idea on topical naproxen/alcohol topical that was effective until our family doctor back in town. I will add GSE to her daily remedy. Thanks for your concern and being a great human being. I wish there was way for people to communicate with you through phone call. Prednisone caused her sugar very high and had to control with insulin pen, but the trade off is worth it because the pain is so awful. Thanks for your time.

Hi Peter,

For gout, Dr Sten Ekberg (You Tube) says excess sugar/ fructose leads to a build up of Uric acid and insulin resistance with the subsequent crystal build up in joints. Sugar really messes up hormones.

Peter,

Thank you for saying that and thank you for the update! I am glad the topical naproxen was effective for her severe gout pain! It is probably a good idea to keep that on hand for pain management since in your wife's case, it avoids systemic usage of naproxen and the spray makes application very easy. I'm glad you didn't use the aspirin as that could make it worse.

The GSPE should help to reduce the elevated uric acid level, that can occur in diabetics and cause gout. I don't know if you ever started her on a bioavailable form of magnesium such as magnesium glycinate for the diabetes as discussed in the recent diabetes article, but magnesium is also beneficial for kidney disease as I mentioned, but it is also beneficial for lowering the elevated uric acid level (hyperuricemia) that causes gout as discussed here :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872714/

Here is a relevant quote from the link :

' Our results indicated that increased magnesium intake was associated with decreased hyperuricemia risk. It also indicated the importance of recommended dietary allowance (RDA) of magnesium and the potential function of magnesium intake in the prevention of hyperuricemia. '

So in this case, magnesium is a "threefer", it helps relieve elevated glucose levels and improves insulin function in diabetes, it helps improve kidney disease :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484355/

and it helps reduce elevated uric acid levels in gout!

Just getting the RDA of magnesium from food and or supplement should be sufficient and agreeable with her doctor.

Art

Art,

Thanks Art!

Is one better than the other? promoted by Sugar Doctor in YouTube

Dihydroberberine vs berberine

My wife has been using below Mag Glyicinate, is this brand ok? or Please recommend.

https://www.amazon.com/gp/product/B0B6CTYD6S/ref=ppx_yo_dt_b_search_asin_title?ie=UTF8&psc=1

Peter,

When you look at the label of the supplement you purchased, it shows that there is 400 mg of magnesium glycinate and 60 mg of magnesium (as magnesium glycinate) which is only 14.29% of the daily value.

This is highly misleading because it tends to make a person think that they are getting 400 mg of magnesium which is approximately the daily value of magnesium for men. In fact, you are only getting 60 mg of magnesium. Since the daily value for women is 320 mg, your wife would have to take 5 of these capsules per day just to get to 300 mg and would have to get the remainder of the RDA from the foods she eats. If she is only taking one capsule per day, that would not be enough to help her glucose level, kidneys, heart, PN or gout.

To further confuse the issue, they say, 'Serving Size 1 Capsule'. This could lead you to think you are only supposed to take one capsule per day.

What matters is the total elemental magnesium that you are getting per day.

For comparison, look at this label on another magnesium glycinate product :

As you can see from this label, each capsule delivers 90 mg of actual magnesium, so your wife would need to take 3 capsules in order to get 270 mg of magnesium and then get the remainder (50 mg) from her food intake to reach the RDA of 320 mg day for women. You can see at the top of the label it says to take 1 to 3 capsules per day. Imo, this label is more accurate than the label on the product you mentioned, because it clearly lets you know how much magnesium you get per capsule and it lets you know that you can take up to three capsules per day.

The magnesium glycinate that I take gives 120 mg of magnesium per capsule, so I take 3 capsules per day for a total of 360 mg of magnesium and then get the remainder from my food to reach the RDA for men of 400 mg to 420 mg/day.

Assuming that your wife has only been taking 1 capsule per day delivering just 60 mg of magnesium, I think moving the dose closer to the RDA for women will start to help her see the three previously mentioned benefits that magnesium has shown in studies. Spreading the dose over the day should be most effective.

Peter, when it comes to supplemental magnesium, imo, the labels could be much clearer than they currently are. I get that manufacturers are trying to make their product sound best in a very competitive field, but realistic recommendations on those labels would be highly useful for all of us end users!

Regarding Berberine and Dihydroberberine, I do not recommend Dihydroberberine because imo, it has insufficient studies to support its use whereas berberine has plenty of studies and of course, Dihydroberberine costs more. When there are more studies in humans to clearly show that Dihydroberberine is superior to berberine over longer term studies, then I will agree, but not until then. I'm not interested in being a guinea pig for dihydroberberine.

Berberine is proven effective for many health issues including gout, cardiovascular disease, diabetes, diabetic peripheral neuropathy, liver health, diabetic retinopathy and kidney disease to name a few benefits. These would all be important for your wife! If it ain't broke, do we really need to fix it?

Art

Art

I just ordered the corrected magnesium. Thanks a million!

https://www.amazon.com/dp/B0058HWV9S

Peter,

The magnesium glycinate that you have is probably fine, it just takes more capsules per day, so you might as well have her use it up at the corrected dose rather than letting it go to waste.

Art

Peter,

That is considered as effective for anemia. What side effects is she having from taking it?

Art

Hi Peter,

If there is one thing you do, please stop your wife's iron supplement and encourage her to take trace minerals instead. I use Aussir Trace minerals but there are many out there.
There is a direct relationship between iron overload and gout. If she is appearing “anemic” on labs, that likely is because she is out of iron homeostasis.
Uric acid is an antioxidant. Arise in your acid means that there is a rise in iron induced oxidative stress. Her body may be producing excess uric acid just to come back the iron that is not free-floating in the blood, so it would not be picked up on a blood test, but it is rusting inside of her cells. She likely has overproduction of iron stored in her tissues. This is not something you can easily test for it unless you do a biopsy or HTMA.

https://pubmed.ncbi.nlm.nih.gov/10616042/

What's her diet like? Is she eating any processed food whatsoever? If so, our body is riddled with excess iron. Nearly all of our processed food, milk, grains are fortified with iron oxide. It's toxic stuff.

what is her stress level like? I think you are definitely on the right track with supplementing magnesium. I would encourage you to take at least 400 mg of magnesium in glyconate in the evening. During the day she can take magnesium three and eight or magnesium taurate or magnesium malate. Also 400 mg. She can also rub it on her skin as an oil or as a spray, and she should be taking Epson salt baths. in order to bring her body back into homeostasis with her minerals, she should absolutely be taking some sort of an adrenal cocktail if under any stress, then whole vitamin C every day multiple times a day whether it's to her food or a supplement. Not ascorbic acid or sodium ascorbate! Whole food, vitamin C.

Thank you very much!

Hi Arlene, The daily dose of magnesium for women is 310 - 320 mg of magnesium while the dose for men is 400 - 420 mg of magnesium per day. What you have to keep in mind is that this is the actual amount of magnesium you are getting minus whatever has been added to it . As a basic example, Magnesium glycinate is a popular option for magnesium, but often times manufacturers include the glycinate and the magnesium total on the front of the label, but only give you the breakdown in the fine print on the back of the label. Here is a link to a typical product on Amazon :

Https://www.amazon.com/Magnesium-Glycinate-Capsules-Chelated-Purified/dp/B0C88BJYX2/ref=sr_1_8?crid=26OUAC9YENDL1&keywords=magnesium+glycinate&qid=1702578049&rdc=1&sprefix=magnesium+glycinate,aps,149&sr=8-8

Open the link and you can see on the front of the label it says " Magnesium Glycinate Capsules 500mg " which may lead a person to believe that just one capsule will give you more than the daily requirement of magnesium. When you open the window that shows the back of the label, you see that each capsule only contains 90 mg of actual magnesium. The rest is the glycinate component. So with this particular product, a woman would need to take 3 capsules for a total of 270 mg of magnesium and make up the difference from magnesium derived from food intake to reach the 310 - 320mg/day. A man would have to take 4 capsules of this product to get 360 mg of actual magnesium and make up the difference through food containing magnesium. One capsule of this product would not be very helpful for the intended purpose. I hope this was clear to you because these sellers seem to go out of their way to make things not very clear when it comes to magnesium supplements! Art

Hi Caseyruth,

The following study may be of interest to you :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921640/

Here is a relevant quote :

Our results suggest that there is eGFR improvement after taking astragalus-containing preparations in mild to moderate CKD cases as reported previously. The findings should be considered with caution due to major limitations such as small sample size without optimum control, short follow-up period, and incomplete data. Further adequately powered and designed studies are needed to confirm the efficacy and safety of the long-term use of astragalus root in patients with mild to moderate CKD.

Art

Hi again, Caseyruth,

The following may also be of interest to you :

https://www.earthclinic.com/cures/chronic-kidney-disease-art-solbrig.html

Art

Hi Yve,

You didn't give a lot of info to go on, such as type of cancer, location, specific cancer treatment, cancer grade or cancer stage. So based on the issue that you did mention, that the treatment is causing an elevated creatinine level, I would say that if that treatment is intended to be continued, it may be helpful to look at supplements and foods that are likely to help protect the kidneys against chronic kidney disease (CKD) and other damages or reduce creatinine levels or both. Here is a list of helpful supplements or foods :

1. Magnesium in a bioavailable form such as magnesium glycinate or magnesium citrate if there is constipation involved. Magnesium has an excellent safety profile and can also be gotten from many foods.

2. Vitamin B1, B2, B6 (P5P), B12, Biotin, Folate (not folic acid) and Pantothenic Acid. The B vitamins are also available in many foods and should be compatible with most treatment options.

3. Melatonin and melatonin lotion. Melatonin has shown synergistic effects as well as protective effects with chemo, radiotherapy and immunotherapy, plus it has multiple anticancer effects of its own while having a better safety profile than almost all current cancer treatments. Its kidney protective effects are many. Melatonin also has multiple heart protective effects and this is important because cancer therapy has been shown to potentially cause damage to the heart. Melatonin lotion can also help with radiotherapy related burns. Melatonin has also shown the ability to help improve CD4 T cell function. ML can reach much higher local tissue levels than even high dose oral melatonin and that can often be useful in certain situations.

4. Vitamin C

5. Alpha Lipoic Acid (ALA)

6. N Acetyl Cysteine (NAC)

7. Vitamin D- Has shown some benefit with certain cancer treatments, but it can sometimes raise creatinine levels. On the other hand it has kidney protective effects.

8. Eat less red meat and fish products

9. Eat more fruit and berries.

10. Astaxanthin is a supplement with an excellent safety profile, kidney protective effects, creatinine lowering effects with potent NF kappa b lowering effects to significantly reduce inflammation.

You also didn't mention if CKD is present yet or if the elevated creatinine level is the only issue with the current treatment. This would be an important point as it could potentially eliminate certain potential supplements which you might consider using. In any case, you will have to run all supplement options by your husband's oncologists to make sure they will be compatible with every medication your husband is taking.

Good luck to both of you!

Art

Hi SR,

To be honest with you, while I tested CBD oil once, I never discuss or recommend it because there are so many variables when it comes to CBD oil such as if it was derived from cannabis or hemp, does it contain any THC or CBN and various dosing levels which makes it hard to recommend. There is also variability from one product to another and from one manufacturer to another.

When you search PubMed for CKD and Cannabidiol Oil, you get one result that used CBD for pain management only in CKD and here is the link :

https://pmc.ncbi.nlm.nih.gov/articles/PMC10061437/

There are studies involving the use of Cannabis for CKD, but that is not CBD oil, which is what you asked about.

Did the original 5 supplements I suggested in the original article not help to improve your CKD?

Here is the link to the original article :

https://www.earthclinic.com/cures/chronic-kidney-disease-art-solbrig.html

The article only discusses 4, but I added magnesium as it is very useful for kidney disease and this is what I said about magnesium for CKD :

Posted by Art (California) on 10/09/2023 2350 posts
★★★★★

Natural Remedies for Chronic Kidney Disease (CKD) Update 10/9/2023

To add further to the original article on CKD, I would like to include magnesium as being useful for CKD. In the following study, it is suggested that magnesium is also beneficial in the fight against CKD :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484355/

Here is a relevant quote from the multi study review :

' Magnesium acts as a cofactor for antioxidant enzymes, directly scavenges reactive oxygen species, and enhances the expression of antioxidant proteins. Furthermore, magnesium exhibits anti-inflammatory effects by suppressing pro-inflammatory cytokine production and inhibiting inflammatory signaling pathways. Magnesium supplementation has been shown to reduce oxidative stress markers and improve antioxidant enzyme activities in clinical studies. Additionally, magnesium has been found to mitigate renal fibrosis, maintain tubular integrity and function, improve endothelial function, and modulate renal hemodynamics. '

Using a bioavailable form of magnesium seems appropriate. Magnesium glycinate is a bioavailable form as is magnesium citrate. Constipation is common in kidney disease and magnesium citrate is helpful for relieving constipation. If constipation is not an issue, then magnesium glycinate might be a better choice because it is a form of magnesium that is much less likely to cause diarrhea. Magnesium also helps to reduce glucose levels which would be useful in diabetic nephropathy (DN).

In any case, magnesium would be a good addition to the other supplements I mentioned for CKD. This is the current supplement list:

1. Melatonin and or earlier morning and later afternoon sun exposure

2. Fruits and Vegetables

3. Sodium Bicarbonate / Baking Soda

4. Fish Oil

5. Magnesium

:::::::::::::::::::::::::::::

My full list of supplements for CKD is very lengthy (29) and Imo, all of them have more evidence to support their use for CKD than what I found on PubMed for CBD.

Art

You're welcome, Cooking Soda Guy!

Thank you for saying so and thank you for the positive feedback!

It is sad that so many medications for various diseases and health conditions have such serious potential side effects that are sometimes worse than the condition you are trying to treat.

On a related note, the following study adds further confirmation to the many beneficial and protective effects of melatonin on the kidneys as well as mentioning the very safe profile of melatonin in kidney disease :

https://pmc.ncbi.nlm.nih.gov/articles/PMC10047594/

Here is an important quote from this review of the literature :

' The purpose of this review is to provide information regarding the potential benefits of melatonin use, particularly in kidney diseases. The impact on the cardiovascular system, diabetes, and homeostasis causes melatonin to be indirectly connected to kidney function and quality of life in people with chronic kidney disease. Moreover, there are numerous reports showing that melatonin plays a role as an antioxidant, free radical scavenger, and cytoprotective agent. This means that the supplementation of melatonin can be helpful in almost every type of kidney injury because inflammation, apoptosis, and oxidative stress occur, regardless of the mechanism. The administration of melatonin has a renoprotective effect and inhibits the progression of complications connected to renal failure. It is very important that exogenous melatonin supplementation is well tolerated and that the number of side effects caused by this type of treatment is low. '

It seems like a good idea to utilize the protective effects of melatonin on the kidneys and other major organs prior to when you are going to be starting a medication that is known to directly or indirectly damage the kidneys or any other organs such as the heart, lungs and liver. Generally speaking, melatonin will offer better protective effects when started before the offending agent is started.

As always, you will have to get your doctors approval and supervision before using any of these supplements for CKD, to be as safe as possible.

Art

This newer review of studies (March 2023) , adds further confirmation to the effectiveness of Melatonin for kidney disease of multiple types : Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047594/#:~:text=Melatonin has been proven to, without regard to the mechanism. Here is a relevant and important quote from the review : ' This means that the supplementation of melatonin can be helpful in almost every type of kidney injury because inflammation, apoptosis, and oxidative stress occur, regardless of the mechanism. The administration of melatonin has a renoprotective effect and inhibits the progression of complications connected to renal failure. It is very important that exogenous melatonin supplementation is well tolerated and that the number of side effects caused by this type of treatment is low. ' Art

Hello Art,

I ran into your post in Earth clinic looking for solutions to my CKD that surprisingly resulted in a Stage 4 condition, plus Anemia. I read the complete post and was surprised by your 5 natural Remedies to manage the condition. I do take them all, as I am a total fan of Natural Remedies since 15 years ago EC cured my gout condition which was so severe I had gout pain every 4 months, and by taking Apple Cider Vinegar with Sodium Bicarbonate I could walk freely again... they may come evry couple of years if so now. Doctors would prescribe pain killers!!

Now I was told to REDUCE my Magnesium Citrate supplementation and ELIMINATE Sodium Bicarbonate because of its Sodium content. I take 2.6 gr of Mg.Citrate for a 400 mg Magnesium daily dose and my blood level is at 2.4 mg/ml..Big Pharma doctors think that what they do not know should not be taken which is not Logical and not Scientific

What would be the Appropriate Dose of Sodium Bicarbonate you would recommend and how to take it? I have been taking 9 mg Melatonin for years now Orally, do you believe thi sis correct?

Thnks Art, and you have my complete admiration for what you do in your posts in Earth Clinic, Manuel

Hi Manuel,

Thank you for the kind words of appreciation!

You'll have to give me more information so I can give you a more informed answer.

Are you diabetic?

You don't say how you have responded to the regimen compared to before the regimen? Is there clear benefit or no benefit?

Is there a specific reason your doctor wants you to discontinue bicarbonate of soda if it is not having a negative effect on you or your test results in any way or is it having a negative effect?

The dose of magnesium citrate is inside of the RDA for men(400 ~ 420 mg/day of elemental magnesium), but the blood level appears high, if accurate. Is it negatively impacting your test results or health? If you significantly reduce your dose, will they allow using liquid magnesium chloride (spray) topically in the areas of the kidneys?

My list of supplements relating to CKD is very lengthy and I can offer other suggestions for you to discuss with your doctors if needed, but I would like the above questions answered if possible.

Here are a few for them to consider as replacements :

Blueberry Extract

Stinging Nettle

Silymarin

Art

Thanks for your reply Art,

Regarding if I am Diabetic, the answer is NO

I only started the Diet/Regimen a bit less than a month ago.. It is very strict keeping the following limits: Protein from 47 to 62 gr....Potassium from 2.000 to 2500 and Phosphorous from 800 to 1000 milligrams... with 15 day average at 51,1840 and 790 respectively, and I am keeping track with values per 100 gr. of each food in an Excel program...Absolutely no salt in food Too soon to verify if the diet is the key variable in the 20% increase in TFG because I also take 4000 IU Eritropoyetin injection weekly (to fix Anemia) plus the the 5 supplements you recommended.

My Doctor did not say to discontinue the Sodium Bicarbonate.. It was Chat GPT which at first said that Sodium was a NO NO ...In reality 2 grams of Sodium Bicarbonate only has only a few milligrams of Sodium molecule.. So I sent Chat GPT the link you posted of NIH and it changed its mind and said that a 20% decrease in kidney decay was very meaningful and it seemed Ok to take it.

According to the Lab Limit,

Magnesium level in Blood of 2.4 mg/dl touches the maximum ... Could it be damaging the kidneys?? If not I can keep taking the 400 mg. of Mg.

Taking care and slowing down my CKD is the objective now, so Please send me the complete list of supplements to help this issue.

By the way do you think that Colloidal Silver of very small particles at 10 ppm may damage the kidneys? it cures too many things.

Thanks again for your continuous interest

Manuel

Hi Manuel,

Regarding AI in general, there seem to be many reports on the internet discussing the reliability of AI reports. Personally I feel more comfortable with actual studies in people or at least animals to use as guides. As an example, I asked an AI a question regarding Parkinson's disease and then asked the same the very next day and the two answers were not the same. I understand that as the science evolves that AI should be constantly updating their data, but this seems like it would only happen after at least a month has passed, not the very next day!

As I said, in my opinion, your magnesium level seems high and significantly lowering the dose seems appropriate. Perhaps take a break from oral magnesium citrate and switch to magnesium chloride spray (mag oil) applied topically over the kidney areas front and back each day to try and target the kidney area. Mag oil ultimately goes systemic anyway.

Since you are at an advanced stage of CKD (stage 4), determining a proper dose of sodium bicarbonate will have to be determined by your doctor because regular monitoring will be needed. They will first have to determine if your bicarbonate level is normal and determine dosing accordingly from there. Here is a human study link to show to your doctor so that your doctor can understand that sodium bicarbonate has health value for your kidneys and also to give a starting guide in terms of dosage :

https://pmc.ncbi.nlm.nih.gov/articles/PMC11843131/

Here is a relevant quote from the human study :

' In this randomized, interventional 3-arm trial of participants with macroalbuminuric, primary hypertension-associated CKD and normal eGFR, dietary acid reduction over 5 years with either F&Vs or NaHCO₃ (HCO₃⁻) yielded improved (i.e., less acid) systemic acid-base status. Improvement was manifest by parameters not usually assessed clinically, including less acid accumulation and greater urine citrate excretion (8-hour UcitV). Improved acid-base status was also manifest by parameters assessed clinically, including higher levels of PTCO₂, PHCO₃⁻, and PCO₂. The 2 intervention groups had lower UNAE excretion than UC, consistent with a reduced acid challenge. Furthermore, improved acid-base status was associated with less oxidative stress assessed by lower U8-iso excretion, and less kidney injury assessed by lower UACR, urine N-acetyl-β-D-glucosamine, and urine angiotensinogen excretion. Indeed, both intervention groups had higher eGFR at 5 years than UC. These data show that typical modern diets, largely acid-producing, ⁴ can cause sustained acid accumulation in those with normal eGFR, similar to patients with CKD and reduced eGFR. In addition, this acid accumulation can be reduced by less acid-producing foods or by mineral alkali like NaHCO₃; both interventions were associated with less kidney injury. '

The graphs in the above study link are very revealing and may be what it takes to show your doctor the usefulness of using sodium bicarbonate long term as this was a 5 year study.

As to the 9 mg of melatonin, in studies melatonin starts to show benefits for humans at 1/2 (.5 mg) a milligram. In your case though, you are apparently tolerating the 9 mg/day dose well so far. Your doctor will have to decide if a further increase in dose will be good or not because it will also have to be compatible with other meds you may be taking. Pretty much all supplements and their dosing will need to be approved by your doctor since you are in stage 4 CKD.

Do you have hypertension? You didn't mention if the cause of your CKD is known. If you do have hypertension and are on a specific hypertension med, you might ask your doctor if you can switch to Beet Root Powder Capsules (BRPC) as these can lower blood pressure while potentially offering benefits for the kidneys at the same time. I like when a single supplement can have multiple uses.

As to other supplements to consider for CKD, the three supplements I mentioned are a good place to start since your doctor will need to approve and supervise them and I think these three may have a better chance of meeting your doctor's approval and will probably be at the supplement limit for your doctor in number. Again, those three at label dosing are :

Blueberry Extract

Stinging Nettle

Silymarin

These three are quite potent and likely to have synergy due to varying methods of action in CKD. All three have very good safety profiles which your doctor should check and is especially important in your case.

Art

Wow what a ton of information

I had a busy end of July so I did not see your post till today. I neeed to read it all carefully and study the link you pasted deeply

Yes the GPT does make mistakes and also reconsiders what it says when differences are pointed out... Bu are doctors a lot better?? Many doctors are clueless of many important things... Most here have no clue as to what you post...They look at you with a funny face when you quote HC (my serious gout issue was not cured by any doctor- Paikillers galore - and HC did the job with ACV+ Sodium Bicarbonate.

Will keep in touch Art.. a total pleasure reding you...Willl have some questons.

Best, Manuel

I carefully read all your posts I am doing the 5 steps you recommend for the CKD as some were in my usual schedule. In a post above you say " My full list of supplements for CKD is very lengthy (29) " Can you send me or post the list? If withËTMquantity better yet. Also whichËTMwould be, from you experience, the milligrams of Sodium Bicarbonate to takefor the CKD pausing of 20% effect of the graph of NIH? With great appreciation for your effort in helping people: It is a blessing which humanity should imitate instead of fighting with each other.. Manuel

Hi Manuel,

In the article I included the link to a study that used sodium bicarbonate. Here is a quote showing the dose used :

' Oral sodium bicarbonate supplementation was given at a dosage of 1.82 ± 0.80 g/d, whereas the control group received standard treatment. '

Warning :

Because hypertension can sometimes be the cause or contributing factor to CKD, this dose will have to be reviewed and adjusted by your doctor after your doctor makes sure that your blood pressure is well controlled before starting you on sodium bicarbonate, as it contains salt which can potentially increase hypertension. I am not a doctor and can not make that dose adjustment for you.

As far as other supplements, I already mentioned three that suggest potential benefit in CKD, that your doctor is likely to approve and should be more than helpful in managing the CKD.

Art

My blood pressure is around 160/80 most of my living years

I am not a doctor obviously.... so can you tell me the milligrams of Magnesium corresponding to the dosage of 1.82 ± 0.80 g/d, you mention? ..I have no idea what that it is.Yes, as you say Miligrams of available Magnesium in the compount/supplemen

You, who different from the 90% of doctors, do RESEARCH, and in my opinion are far more capable of finding solutions..Never did I find a doctor who looked at Earh Clinic.. They smile and disegard when I mention it.

Can you post the 29 other supplements you have founwhich are positive for the kidney?

Many many thaks as usual, Manuel

Hi Manuel,

The 160 is high, the 80 is normal, but the 160 is concerning and very concerning with stage 4 CKD. Your doctor should be working on trying to normalize that. You can ask your doctor about possibly using beet root powder capsules (BRPC) to try and further control that 160. BRPC has also shown potential benefit for CKD, so it seems worth having that discussion with your doctor. Given that longer term use of some blood pressure medications are known to cause kidney damage, your doctor may be more open to BRPC to improve your blood pressure. Here is a brief abstract mentioning beet root as possibly beneficial for CKD :

https://pubmed.ncbi.nlm.nih.gov/34613396/#:~:text=Abstract, All rights reserved.

Here is a relevant quote from the link :

' Growing evidence indicates that diet is an indispensable ally in the prevention and management of CKD and its complications. In this context, the root vegetable beetroot (Beta vulgaris rubra) deserves special attention because it is a source of several bioactive compounds, such as nitrate, betaine, and betalain, and has shown beneficial effects in CKD, including reduction of blood pressure, anti-inflammatory effects, and antioxidant actions by scavenging radical oxidative species, as observed in preclinical studies. Beetroot consumption as a possible therapeutic strategy to improve the clinical treatment of patients with CKD and future directions for clinical studies are addressed in this narrative review. '

The BRPC could also lower the 80, but there is some play room there if it does go lower.

They were using sodium bicarbonate in the study I linked to, not magnesium.

What they are giving is a dose range, so apparently not everyone got the same dose and perhaps it was based on weight or some other measure. The dose they showed is 1.82 +/- .80 g per day. I take the g to be grams. So I read that as a dose range of 1020 mg - 2620 mg per day. This is a very wide dose range and that is why I say your doctor will have to determine the proper dose for you or possibly start you at the lowest dose and steadily increase the dose over a period of time while monitoring your blood pressure and kidney function regularly. The last option seems a safer way to go, but your doctor will have to make that determination. It may help for you to make a copy of that 2024 study to give to your doctor so he can be clear on the study parameters and findings. Here is a link to the full study :

https://pmc.ncbi.nlm.nih.gov/articles/PMC11843131/

There is no way your doctor is going to consider or even review a list of 30 supplements to consider for your use, but on the other hand, your doctor may seriously consider the three I mentioned to you previously and all three should be beneficial toward your needs. Again those three are :

1. Blueberry Extract

2. Silymarin

3. Stinging Nettle

No matter what you decide, your doctor's approval and supervision along with regular testing are absolutely needed for everything you are taking or planning to take. Stage 4 CKD is a severe stage of kidney damage and I don't take that lightly.

Art

Hi again, Manuel,

In my previous reply, please change #3. from Stinging Nettle to Astaxanthin (AST) as AST is generally very well tolerated and more studied for the purpose as a kidney protectant. I'm thinking that the very good safety profile and more kidney related studies may make it a more desirable choice for your doctor over the less studied stinging nettle for kidney issues.

Art

Canyou give an idea of thedosage of Astaxanthin in Milligrams

Will start withe the 100 mg Sodiunm Bicarbonate for 1 month monitoring blood pressure and do a Creatinine level test to check

thanks one more time

Manuel

Hi Manuel,

Most newer human studies have used from 8 mg/day up to 24 mg/day of Astaxanthin, but with all things you try or test, your doctor will need to approve and supervise your use of astaxanthin since you are in stage 4 CKD. I still use a 24 mg liposomal form of Astaxanthin and have used it for years to increase endurance as I wrote about here a few years ago :

https://www.earthclinic.com/supplements/astaxanthin-for-endurance.html

When you discuss it with your doctor, see if he will consider the 24 mg dose.

Art

Sorry, I made a typo and put 100 mg Socium Bicarbonate ehen the real number to start and monitor is 1000 as the NIH study reached higher values.

Daily dosage for Blueberry Extract and Silmarin? Anything useful to slow the CKD progession should be considered for evaluation!!

Best, Manuel

Hi Manuel,

The label recommended dosing will be fine for those two, but when you talk to your doctor, ask if you can go higher on the astaxanthin dose since it is well tolerated by most people.

Here is a link to a typical silymarin product that uses one soft gel per day :

https://www.amazon.com/Supplements-Silymarin-Thistle-Strength-Softgels/dp/B01M9GEX1Q/ref=sr_1_1?crid=2C4RYQ3GWOLV0&dib=eyJ2IjoiMSJ9.vRW0FL6BpWpAPDJrISvhdGiUctnbYdHL_nTj05lUpyB-jdnJidyCDFEGIBHVfnsAHB46I4Mg_HVTiCIX_On4xxg_CyBGqeLdg-kIXh_AUIZF7qYIsjTg0GydAhPlxtP9C0CD7PjZSMCXLmmJ8uE2M-iiWZ7lLIpz2fMawPNdni_E_vy988BOW3aDXlfcbHg115sWa8kks7nYlIwm9OWfMNeqemm8ASybzC2LdOWCxcFzEllcvsLuaw5px9hHJ-7IF4PYsubuGYz6RjJgFhF6N2k755cO3VUEqN3_BP6RMSU.1YKv8LMDEqjf_eKzhoKxZ-dwF0qMGwQKbnx8Po7pfgM&dib_tag=se&keywords=now+silymarin+450+mg&qid=1759423819&sprefix=NOW+silymarin,aps,159&sr=8-1

Be sure to use a product that is only silymarin and nothing else. Some manufacturers often include something like dandelion or artichoke and this would be very bad for you. The problem is that most manufacturers don't list the " other ingredients" on the front of the label, but rather only in the fine print on the back of the label. So you need to choose the supplements carefully and fully read the label to make sure what is actually in the product.

Again, your doctor's approval and supervision will be required for every supplement or alternative that you want to take for your CKD.

Art