Lysine
Health Benefits

L-Lysine Health Benefits | Immune Support & More

| Modified on Feb 02, 2025
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L-Lysine is an essential amino acid that plays a crucial role in immune function, muscle repair, collagen production, and antiviral defense. Since the body cannot produce L-Lysine on its own, it must be obtained through diet or supplementation. This article explores the many health benefits of L-Lysine and how it can support overall wellness.

What Is L-Lysine?

L-Lysine is a building block of protein that is vital for tissue growth and repair. It is naturally found in foods like meat, fish, eggs, dairy products, and legumes. Supplementing with L-Lysine can provide additional health benefits, especially for individuals who have a deficiency or require extra support for specific conditions.

Key Health Benefits of L-Lysine

1. Supports Immune Function

Why It Works: L-Lysine enhances immune system activity by promoting the production of antibodies and immune cells that help defend against infections.

How to Use: Take 500-1,000mg of L-Lysine daily to support immune health.

2. Helps Prevent and Treat Cold Sores (Herpes Simplex Virus)

Why It Works: L-Lysine inhibits the replication of the herpes simplex virus (HSV-1), which causes cold sores.

How to Use:

  • For prevention: Take 500-1,500mg daily.
  • For active outbreaks: Increase to 3,000mg daily until symptoms subside.

3. Promotes Muscle Growth and Recovery

Why It Works: L-Lysine is essential for protein synthesis and muscle tissue repair, making it beneficial for athletes and those recovering from injuries.

How to Use: Take 1,000-2,000mg per day for muscle support.

4. Supports Bone Health

Why It Works: L-Lysine enhances calcium absorption and helps maintain strong bones, reducing the risk of osteoporosis.

How to Use: Take 1,000mg daily in combination with calcium and vitamin D.

5. Reduces Anxiety and Stress

Why It Works: L-Lysine has been found to help reduce cortisol levels and may aid in managing stress and anxiety.

How to Use: Take 500-1,500mg daily for stress management.

6. Supports Heart Health

Why It Works: L-Lysine may help reduce plaque buildup in arteries and support cardiovascular health by promoting healthy circulation.

How to Use: Take 1,000-2,000mg daily for heart support.

7. Aids in Wound Healing

Why It Works: L-Lysine is involved in collagen production, which helps repair skin tissue and speed up healing from wounds or surgeries.

How to Use: Take 1,000mg per day to support healing.

Food Sources of L-Lysine

In addition to supplementation, L-Lysine can be obtained from the following foods:

  • Chicken and turkey
  • Fish (salmon, cod, tuna)
  • Eggs
  • Dairy products (cheese, yogurt, milk)
  • Legumes (lentils, beans, chickpeas)
  • Nuts and seeds (almonds, sunflower seeds)

Recommended Dosage of L-Lysine

The appropriate dosage of L-Lysine depends on the intended use:

  • General health support: 500-1,000mg daily
  • Cold sore prevention: 1,000-1,500mg daily
  • Active cold sore treatment: 3,000mg daily
  • Muscle recovery and bone health: 1,000-2,000mg daily

Possible Side Effects and Precautions

While L-Lysine is generally safe, some individuals may experience:

  • Gastrointestinal discomfort (nausea, diarrhea)
  • Increased calcium absorption (monitor if taking calcium supplements)
  • Potential interactions with certain medications

Consult a healthcare provider before taking L-Lysine, especially if you have pre-existing conditions or are on medication.

Have You Used L-Lysine?

Share your experience below! How has L-Lysine helped you with immune support, cold sores, or muscle recovery?


The comments below reflect the personal experiences and opinions of readers and do not represent medical advice or the views of this website. The information shared has not been evaluated by the FDA and is not intended to diagnose, treat, or prevent any disease or health condition. Always consult a qualified healthcare professional for medical concerns.

Anxiety

1 User Review
5 star (1) 
  100%

Posted by Alex (Paris, France) on 11/11/2023
★★★★★

I feel better after using lysine since 2 days, I'm less stressed and anxious. I'll keep taking the supplement and will update.


Broad Benefits

1 User Review
5 star (1) 
  100%

Posted by Joyce (Joelton, Tn) on 11/10/2007 490 posts
★★★★★

Editor's Choice

...I also caught another co-worker alone one day and said, "I don't want to embarrass you but I do want to tell you that if I'm ever diagnosed as HIV+ I would be taking l-lysine like it was going out of style" after observing him cornering one of the doc's , to look at his throat for the umpteenth time. His reply, what is it, where do I get it and how do I take it". Answer Walmart, Kmart, Walgreens, GNC stores, etc. Try to find the l000 mgm or 1 gram tablets, take 2 tablets breakfast, lunch, supper and bedtime. He was also told that if it didn't help him it wouldn't hurt him. I never asked if he got it, but he started looking better, missing work less often, and turned in his resignation stating he was going back to art school. Sounds like he expected to have a future. Unfortunately this story did not have a happy ending - seems he had a little too much to drink, backed his wife into a corner, and died from a stab wound inflicted by the butcher knife she carried into that corner with her for self-defense.

The reason I suspected that it might work was because it works against the common cold, mono (kissing fever), influenza. herpes type i & 2, chickenpox, shingles (herpes Zoster), all viruses, so just maybe it would work against HIV also, since it is a virus. An interesting little aside here, I recently read where some psychic claimed to have asked the other side about a cure for AIDS and was told that it had been around for centuries, that the cure was at hand and involved a protein. L-lysine is one of the amino acids which are protein. just maybe it would work against HIV virus.

Maybe we should post the benefits of L-lysine on Earth Clinic before orthodox medicine learns that it works well against viruses and starts debunking it because they can't patent it and keep you coming back to them for prescriptions.


Canker Sores

10 User Reviews
5 star (7) 
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1 star (1) 
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(2) 
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Posted by Whiperingsage (Northeastern California) on 08/07/2015 45 posts
★★★★★

I thought lysine wasn't helping my cold sores when I took 500 mg and dicovered I should be taking more. I have been on 1 gram a day for years and any time I run out or forget, my cold sores fire up within 2 days.

Recently my cold sores popped out even on 1 g and gallstones and ulcer symtoms came back, I was stressed because I had just gotten out of the ICU with severe bleeding ulcer and loss of 5 pints of blood (extreme stress). I researched until I found a lysine link and found deficiency can cause anemia (a constant problem for me) and many other symptoms asociated with anemia. I googled lysine-gallstones and found conflicting info- but tried 5 g of lysine and the pain was releived and I slept without benedryl and all the usual herbs I have to take to sleep. And the cold sores are going away. I don't know what stimulated this last period of stress that I would need a higher dose of lysine, but I will have to be more mindful of getting enough protein.


Canker Sores
Posted by Joe (NYC, NY) on 11/02/2008

Editor's Choice

I have taken L-Lysine for canker sores and it worked great. I havent had one since.

If taken for a while L-Lysine can have an effect on your liver, my mistake was that i kept experimenting and supplementing on it even though i did not need it. It is good but you should pay attention to your arginine levels (consume arginine foods or supplements), as an unsafe drop in those levels can damage your liver. As in my case after consuming about 2-3 grams a day for about 3-4 months resulted in a morning with pain in my liver and a feeling as if i had a cinder block under my ribcage(i had no idea there was such a thing such as liver pain and swelling). Stopped supplementing on it, and 2 days after my liver felt way better. My cholesterol levels were also unusually high during supplementation and they went back to normal after stopping, so people should keep these things in mind, i know its easy to miss these warnings since i missed them myself. The beautiful thing about the liver though is that it can repair itself, but that doesnt mean you shouldnt be careful. Milk Thistle can help repair your liver. And if i had to do this all over again i would take L-Arginine along with L-Lysine. It would be great if someone posted these warnings in the main description for awareness so they can learn from my mistake. Thanks

Replied by Bill
(Davis, CA)
12/22/2008
★☆☆☆☆

WARNING!

One should never take as much Lysine as you have suggested. I have been taking L-Lysine for 15yrs for herpes and have never heard of such a high dose. Most medical practictioners suggest 500mg daily before food or other aminos and during an outbreak up to 1500mg/day. This has helped me control my outbreaks for a long time. Not one source that I have researched during this time has suggested such a high dose. Overloading of the liver would seem common sense with that dose.

Replied by Anthony
(Canberra, Act, Australia)
02/13/2012

Hello Bill, Continuing from your suggestion re dosage of Lysine, I am aware that Linus Pauling protocol (for heart disease) suggests high dosages ie up to 6 gms Lysine per day. This protocol also suggests Vit C of up to same quantity ie 6 gms. I have tried to research this issue but could not get answer as to What other Amino ACids to take with such high dosage of L-Lysine.

I read some where in this website, to take L-Arginine along with L-Lysine. Do you or others have any suggestions on this issue ie how much L-Arginine to take alongwith say 6 gms of L-Lysine.

EC: Can we pass this question to Ted for his expert comments please.

Anthony

EC: Forwarded to Ted, per your request.

Replied by Mmsg
(Somewhere, Europe)
02/14/2012

Anthony: I tried l-lysine numerous times for canker sores, sometimes it helped, sometimes not. I do take 1 gr. Vitamin C daily.

Then I was told to take the l-lysine away from foods. I now take one capsule of 500gr. with my morning drink as a precaution, because the CANKERS ARE GONE!!! Thank G-d! So in my experience it's not the huge amount that you might need, it's the taking it far from meals, preferably in the morning.

Replied by Anonymous
(Miami, Florida)
07/04/2013

Interesting I have been taking four caps of lysine and started having liver pain burning feeling for weeks, I read high protein diet can cause this too, it creates high acidicity and the liver doees not like this. My doctor ran tests for liver enzymes check and of course Hepatitis right away I feel kind of silly thinking that perhaps the lysine is the causative factor anyhow I stopped the Lysine right away.

Replied by Marloef8
(Comox Valley)
01/13/2015

This is to reply to Anthony from Canberra:

Just come across an interesting article from Nutrition Review: The Collagen Connection Linus Pauling's Unified Theory of Human cardiovascular Disease that might help with your question.

Replied by Ron
(Mesa)
10/21/2015

Fighting cancer recommended is 112 grams per day.....4 oz

Replied by Speedwell
(Earth)
10/24/2015

4 ounces a day? Recommended by who, the morgue?

Lysine is definitely processed in the liver, so don't take a high dosage along with alcohol, paracetamol (Tylenol for you Yanks), or other medications processed by the liver such as metformin.


Canker Sores
Posted by Carol (Hamburg, NY) on 03/14/2007
★★★★★

For years, my teenage grandchildren suffered through excruciatingly painful episodes of canker sores. After trying & failing with many remedies suggested by their mother & others, including their M.D., they finally tried the old-fashioned home-remedy that their great-grandmother used! L-lysine, a simple, low cost cure. They now are tried & true users of L-lysine, and have almost become heroes with their college friends. The treatment is: Immediately upon the beginning of an out-break, take two 500 mg. tablets. Continue taking one 500 mg. tablet each day until 2 or 3 days past the day the canker sore appears to be healed. "L-lysine is an essential amino acid needed in our diet. It is found in animal protein, such as milk protein. It is recommended that young adults need approximately 23 mg of L-lysine per day per kilogram (10 mg per lb) of body weight. The proteins of cereals; wheat gluten, for example, do not provide enough L-lysine (Columbia University Press Encyclopedia)". Little do the young believe that Grandmother's could be so smart - until they try the "old- fashioned home remedies!


Canker Sores
Posted by Maya (Ft Leavenworth) on 11/19/2005
★★★★★

My daughter and I would get canker scores often, until a friend told me about Lysine. We both take one a day, and if ever one starts to appear, then take 2 pills and the scores are gone. I told a great friend who had very dry lips and the lysine has worked for her as well! Love it! The pain is gone!


Canker Sores
Posted by Thesa (Colorado Springs) on 11/15/2005
★★★★★

My 5 year old daughter came down with a horribly serious case of canker sores. Her mouth had several sores on her tongue, cheek, and gums. Her gums were so red and swollen you could barely see her little teeth. Her breath was absolutely terrible and she barely ate or drank a thing. Finally after a week of different attempts, we had her gargle with 6 drops of tea tree oil in 4 oz. of water three times a day, gave her half an adult dose of L-lysine crushed up into water once a day, gave her a homeopathic every hour and had her drink 16 oz. of water with acidophilus/FOS throughout the day. We kept her completely off of sugar, dairy and meat and mostly she ate cottage cheese and plain yogurt. Within one day she was so much better and finally eating and within 3 days totally better!

Replied by Vandi
(Arizona)
10/24/2015
★★★★★

I feel so sorry for your little girl. I hope she came out of it OK. My son has also suffered with cold sores all of his life on his cheek and all across his mouth. Now that he's a young man and has a career this can be embarrassing and painful for him when he has a bad outbreak. I just advised him to start taking lysine on a daily basis.I advised him to take one tablet per day this advice was given to me by a good friend who tried it and hasn't had a cold sore in years. I started nearly a year ago and haven't had one.


Canker Sores
Posted by Lynda (Durham, NH) on 10/20/2005
★★★★★

My nurse practitioner recommended L-Lysine for my debilitating canker sores. They would last for weeks and were so bad that the pain extended to my neck and lymph nodes. I couldn't even eat without excruciating pain. When I feel a canker sore coming on, I take 1 gram 3 times a day and the sore is gone within a day or two.


Canker Sores
Posted by Donnie (Spartanburg, SC)
★★★★★

A supplement called LYSINE helps to heal mouth sores faster, just take a 1-gram capsule 2 or 3 times a day.


Colds and Cold Sores

1 User Review
5 star (1) 
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Posted by Baiazid (Gvrd, Bc) on 10/12/2015
★★★★★

I use L-Lysine for cold sores and to keep away the colds. For me it works.

Colds: I use the dose on the bottle for colds and gargle with cayenne powder water as often as I remember to. The worst I get is maybe one day of very mild symptoms. I tried many recipes from EC but for me this one knocks it out of the park.

Cold Sores: I use it a bit more often/day than for colds. As soon as I feel pain or itchiness around my mouth I take L-Lysine then dab the spot with DMSO. I keep dabbing DMSO every time I remember. That's it. It just fails to erupt if I catch it in time, if not, the combination of L-Lysine and DMSO stops it in its tracks, dries it and saves me days of unpleasantness. If I am away from my DMSO bottle, I use H2O2 instead. A fraction less effective for me but it stil works.

I have tried many other remedies for colds and their resulting sores but none have worked so consistently and so efficiently as these have. It takes a bit of time to search and to try them out until you find your own combo.

Thank you EC!


Contraindications

1 User Review
1 star (1) 
  100%

Posted by Oscar (Syracuse, New York) on 02/25/2012
★☆☆☆☆

WARNING!

There is evidence that taking L-LYSINE supplements with a compromised liver and or kidneys is bad for you. This may help explain why some people are having mixed or less than desired effects with the BHT [ butylated hydroxytoluene ] treatment for hepatitis C. Many of these people are including supplements including L-LYSINE supplements as a part of their treatment. It seems this is a bad idea for the treatment of hepatitis. Link here about all this: http://www.livestrong.com/article/394394-l-lysine-contraindications/

And any person who is experiencing both kidney and liver failure should read that linked information and should be especially concerned.

So, if you have a compromised liver and or kidney do NOT take L-LYSINE as a supplement....Oscar

Replied by Denise
(Seattle, Wa)
07/21/2012

Oscar, I have read your reply regarding L-Lysine. "Ted" from this website says, "there are 2 things hepatis C does not like; aspirin and lysine.. He also recommends a protocal of lysine and aspirin for 4 days, taking them for four hours and for 4 days will eliminate hepatitis c. I recall he recommends 4000 mgs of lysine per day..

Just am a bit confused regarding this conflicting info...Thanks

Replied by Mevina
(Texas, Us)
02/11/2018

Saying "hep C doesn't like aspirin and lysine" means they knock out the virus.

Replied by Felina
(Wilmington, Delaware)
03/16/2018

Thank you for this message. I'm so glad I checked before I took it. I'm currently taking mavyrit, its like harvoni. I am struggling with joint and severe constipation side effects. That's why I was tempted to take it. Thank you, for your knowledge. Love and light.

Beloved
(California)
02/05/2022

I see you struggle with constipation. If you have a juicer, then juice some beets and it will make you go.

Replied by Suzy
(Indiana)
03/16/2018

Felina,

Ssorbic acid crystals, vitamin c, mixed with water or taking magnesium will take care of your constipation. Experiment with it a bit and find the right dosage. Black strap molasses daily also fixes the problem. It is high iron if that's something you are avoiding. These have changed my life. I wish you the best.

Replied by Suzanne
(IN)
02/10/2022

Also taking magnesium before bed on a regular basis will fix this.


Dosage

Posted by Colleen (Greenwich, NY, US) on 04/11/2013

I'm reading all this wonderful information about lysine but i'm wondering what type of supplement is everybody using? Are you using typical synthetic, chemical supplements or is it natural from an animal source? I was taking 500mg of L-lysine from CVS until I read about how bad synthetic supplements are for us. I'm curious if people are still getting good results with the synthetic? Thank you!

Colleen

Replied by Plumhappy
(Eugene, Oregon)
04/11/2013

I use liquid lysine. The tablets are too big for the amount you need. The liquid is not so pleasant but I put it in a little bit of water or frute juice and chase is with something with flavor. It comes with a dropper and quite affordable.


Fever Blisters

1 User Review
5 star (1) 
  100%

Posted by Mel (Houston, Tx) on 02/07/2013
★★★★★

I get a lot of fever blisters on my lips from stress and I don't know what. But I started taking L-Lysine and that alone helps keep them away for months at a time and the only reason I might get them might be cuz I forget to take it. When I do get them I use acetone and coconut oil. But L-Lysine works.

Replied by Dee
(Medford, Oregon)
07/08/2013

Mel from Houston.... Do you put acetone on the fever blister? You do know that Acetone is a harmful chemical that nail techs use to take off artificial nails.... It's a hamful substance that I've never heard of anyone using on an open sore. Please rethink this.

Replied by Polly
(Gander, Neewfoundland, Canada)
07/08/2013

Yes you can use acetone in fever blisters-it burns a bit but does not hurt the skin, and gets rid of them very fast--really it wonderful for this--strange but true!!


Food Sources

Posted by Yow_whaz_up (Chinatown, Singapore) on 11/11/2011

I can't find the supplements Lysine and Arginine where I live. The ones I have seen are bits of them in children's multivitamin syrups, which are either inadequate or has MSG added.

I don't know what else to do except making some chicken soup or the pig leg one. For Chinese people, it is kind of like a tradition to cook it if someone in the family feels weak and sick.

Will it have the same effect as taking 1000 mg of lysine to fight against some virus or germ? Will it also be the same as taking 500 mg of arginine to relax that stressful heart? Does the soup also have the same useful lysine and arginine?

Ted from Bangkok, anyone, have you ever drunk dong koi teng (chicken soup with dong koi herb) or ba kut teh (pig leg tea) to kill the fatigue caused by a germ or simply stress?

Replied by Frankiee
(Tennessee, US)
12/07/2014

GNC.com is where you can order the L-lysine online; I believe even though you live in China, you still may be able to have it shipped to your location. I have to tell you, it has worked so well with my sudden development of canker sores, I am just so relieved to know that I have access to it; I will pay whatever amount to obtain it!!


Herpes

12 User Reviews
5 star (11) 
  92%
1 star (1) 
  8%

Posted by Bonita (Rochester, MN, USA) on 01/03/2009
★★★★★

Found this website looking for flea remedies and found so much more! I too am always looking for remedies other than what are mainstream, just because it seems to me there has got to be more than one way to skin a cat, so to speak!

Read about Vitamin D deficincy in The Star Tribune by a doctor at the U of MN who discovered how many people suffer from a lack of it. Of course, I am a blue eyed blond who frys like a lobster in the sun and can't remember when the last time was that I went outdoors without sunscreen and and hat so I began taking a D supplement right away. I take 2000 IU of vitamin D daily. I have to say that I feel pretty darn good considering I have arthritis in all the major joints of my body.

I also have been using lysine to take care of my Herpes simplex outbreaks for years and would not be without it. I find that if I take 4-6 500 mg tablets at the first sign of the itch/tingle on my lip, and then 2 tablets every couple of hours after that, I can most times, stop it in its tracks and completely skip and signs of the break out. If I am nowhere near my supply of lysine and I get those symptoms, taking it at first opportunity causes the leisons to heal very rapidly. In any case, it works for me.

Am going to try the apple cider vinegar thing as well, for arthritis and for the flea problem. Weird that it will be for 2 such unrelated problems but If it works, who cares. It is certainly safe enough. Thanks for being here as a sounding board and gathering of natural remedies.

Replied by Listen 2 Ur Body
(Denver, Co)
07/31/2012

In regards to the warning.....Your typical "Dr. "will almost ALWAYS say "Warning!". They are unfortunately taught to be drug pushers because there is no $ in natural cures. As with anything be aware of how YOUR body reacts, you are your best physician. :).

Replied by Victoria
(Colorado)
01/12/2014
★★★★★

I got tired of spending 20 bucks on abreva that never ever worked on my fever blisters that would swell and become pus filled(and I assume virus filled). I would say on, avg I had blisters at least 3 times a yr. My triggers are sun, stress, trauma, and the occasional accompanying cold. Came on here and read about l lysine. So in middle of hell started a regiment of vit a, e, b complex, echinaecha, goldenseal, and lysine. (I also am prone to stys and they are also triggered by stress, so naturally I was treating that too). The swelling of much lip reduced in a day and both the blister and sty were gone in like 3 days. Now I rarely have either ailment start due to taking it every other day for 2 wks, then week off, then every othet day. Havent. Had either in probably a yr. And that was only because I stop taking it.

Replied by Anjjella
(Usa)
03/07/2014

Lysine cream never realy worked for me, so for yrs I just put up with them. Then I started using iodine for a nail fungus, (which has work well) and wondered if it would help on the lip blisters. So I took a little coconut oil (1 Tblsp) added 3 drops of iodine and started rubbing it into sore on my lip. After repeated use, the one area that used to take over my bottom lip has yet to reappear, even if a smaller one appears in another area of my lips. I stopped getting that crappy feeling like the flu was coming on also. They stay very small. Iodine has worked better than the baking soda paste I used to plaster on them.

But since Lysine has been helping my son with the severity of his acne and scaring when they heal, I have started taking it too since I love cashews and hazelnuts which are high in arginine. hoping it will counter the imbalance.

Replied by Anjjella
(Usa)
03/07/2014

Lysine cream never realy worked for me, so for yrs I just put up with them. Then I started using iodine for a nail fungus, (which has work well) and wondered if it would help on the lip blisters. So I took a little coconut oil (1 Tblsp) added 3 drops of iodine and started rubbing it into sore on my lip. After repeated use, the one area that used to take over my bottom lip has yet to reappear, even if a smaller one appears in another area of my lips. I stopped getting that crappy feeling like the flu was coming on also. They stay very small. Iodine has worked better than the baking soda paste I used to plaster on them.

But since Lysine has been helping my son with the severity of his acne and scaring when they heal, I have started taking it too since I love cashews and hazelnuts which are high in arginine. hoping it will counter the imbalance.



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