The Role of Selenium: Health Benefits, Food Sources, and Research Insi

Anthony, to help your body utilize Selenium take 400-800 iu Vitamin E (mixed natural tocopherols) daily. The Selenium will bond readily w/ the E and get incorporated into your tissues (instead of floating around in the blood) as an antioxidant complex boosting glutathione levels.

Thanks for the response. My doc and I spoke and I'm gonna hold off on the selenium for a month and we are gonna do the 24 hr. urine again. Once I get that back I'll see where my levels are and go from there. Thanks!

Hi, Well, I recently had a urine test and blood work done. I posted a day ago that my urine test came back with very high selenium amount; over 100mcg normal value. Well, my blood work just came in and a few things are off. Maybe someone can guide me a little as I am concerned but my doc didn't seem so. The T4 and T3 were normal but I put the values incase they mean something inregards to the TSH reflex. Thanks!

TSH w/ Reflex to FT4 was 0.39 (0.40-4.50 is normal)
T4, Free was 1. 4 (0.8-1.8 is normal)
T3 uptake was 35 (22-35% is normal)
Alkaline Phosphate was 38 (Low) (40-115 is normal)
Albumin/Globulin ratio was 2. 2 (high) (1.0 - 2.1 is normal)

Thanks again!

Hi Anthony... Selenium is highly important and very necessary when you take higher dose iodine because selenium is used in two ways in the thyroid.

First, selenium is essential for the manufacture of T3 and T4 to prevent the anti-body auto-immune response. Thyroglobulin stored in the thyroid is converted to T3 and T4 by an enzyme called thyroid peroxidase. And hydrogen peroxide -- a free radical metabolite that is normally always produced -- is given off during this reaction. Normally glutathione peroxidase -- an anti-oxidant -- neutralizes and prevents build up of hydrogen peroxide free radicals in the thyroid cells. However, selenium is the central metallic atom for glutathione peroxidase(GP) so if selenium is depleted in diet you may not have enough GP to prevent thyroid cell free radical damage and the inevitable anti-body autoimmune response(thyroid nodule formation and inflammation). So you must always take selenium with higher dose lugol's iodine for this reason.

Secondly, selenium is also involved in the conversion of T4 to the more active T3 form. So if selenium is depleted in the body, there will therefore be higher T4 and lower T3 readings. T4 is also used in the feedback loop with the pituitary gland -- so a false high T4 reading will immediately act to suppress and reduce both T3 and T4 production in the thyroid -- giving an overall hypothyroid effect.

This is why -- if you are taking higher dose lugol's iodine -- you should always follow The Iodine Protocol. Every single one of the nutrients in this protocol is there for a reason. For instance, magnesium is in the protocol to regulate excess calcium in the body(excess calcium inhibits iodine uptake) and magnesium is also involved as a coenzyme with l-tyrosine that converts iodide to iodine for initial storage in the thyroid. So, if you are defficient magnesium in your diet -- you also run the risk of being hypothyroid. The western diet is also well known to be defficient in both magnesium as well as iodine.

A normal maintenance dose of selenium is between 100 mcg and 200 mcg per day depending on your diet.

Hi Anthony... Although your FT3, FT4, TSH etc seem fairly normal, there is one other possible factor that may be causing you problems -- which is Reverse T3 and Reverse T4 clearance.

RT3 and RT4 are produced at a constant output level to further balance the ratio and uptake of mainly FT3/FT4 in the body. This balancing/adjustment of FT3 and FT4 with RT3 and RT4 is a normal body mechanism which mainly happens in the liver. RT3 and RT4 work at the cellular level -- binding to T3 and T4 tissue sites to deiberately inhibit and balance FT3 and FT4 uptake. So if the clearance or regulation of RT3 and RT4 is either inadequate or excessive then this can also cause apparent thyroid problems and symptoms.

RT3 and RT4 clearance problems are normally concerned and associated with liver/kidney problems and not the thyroid.

So, if you still believe that you have hyper- or hypo-thyroid symptoms, perhaps best if you get an RT3 and RT4 check to further confirm if there are any problems in this area.

Hi Bill, Thanks for all the info. Im not taking iodine. I'm not sure if you thought I was. And also, what do these numbers represent, that I'm hypothyroid or hyper? Wouldnt it represent hyper?? I do know a little bit about the thyroid, but not enough to know what I should do.

I do have Ulcerative colitis, a white tongue, and I do believe candida. Would iodine be wise to take? Also, should I be concerned about the Alkaline phosphate and albumin? Thanks again!

Hi Anthony... Your FT4 is in the normal range so your TSH output may be low or incorrect for normalizing FT3 and FT4. The strange thing is that your FT4 is Ok but your FT3 is actually borderline high. A low level of TSH should produce lower levels of FT3 & FT4 but this is not the case. This is confusing, but can be explained in the following way:

* If your Reverse T3 and Reverse FT4 levels are too high -- this will not be reflected in any of the readings you have so far obtained from your blood and urine levels. This can only be obtained from separate and specific RT3 and RT4 readings from the blood. If RT3 and RT4 are high then the absorbtion of FT3 & FT4 at the cellular level will be low -- both RT3 and RT4 inhibit FT3 and FT4 abroption throughout the body -- giving symptoms such as low energy, lethargy, brain fog etc. Therefore as I've said before -- You must get your RT3 & RT4 levels checked to be sure.

* High RT3 & RT4 levels, high albumin levels and alkaline phosphate levels all tend to indicate problems with the liver or kidneys -- not the thyroid. So get your liver(AST, ALT levels etc) and kidney checked out.

* A low TSH output with normal FT3 & FT4 could also indicate problems with the pituitary gland. Both the pineal and pituitary gland are absorption targets for heavy metals and for fluorine and bromine which can definitely effect hormone output levels. So you might need to detox your pituitary gland using green tea, chlorella and cilantro as advised on this site.

* You also have candida and colitis and this is also reason enough to cause debillitating effects on your thyroid and would also indicate that your body needs detoxing. Candida always affects and suppresses thyroid performance over time.

* Candida always drags down the thyroid. And if you don't get rid of the candida, your thyroid and colitis problems may well worsen over time.

Supplementing organic aloe vera juice and regular supplementation of food grade Bentonite clay should help the colitis, but -- from my own experience -- you will have a tough time curing colitis and your thyroid problems if you do not get rid of the candida first. See the Anti-Candida Protocol shown in the link.

Hi Bill, Thanks for getting back to me. The 3 symptoms you have described (fatigue, lethargy, memory issue - my biggest issue) I have them all. My colitis is not that bad. It's more proctitis. I only use the bathroom 1-2 times a day. My bowel movements are never the same, meaning very thin, broken up sometimes; other times normal, sometimes it burns other times it doesn't. I began taking HCL tablets again to help with digestion. I burp alot, however my diet is pretty good. I def believe I have some sort of candida however it my digestion got better I believe the Candida would. I will go see an endocronologist soon. Should I take iodine or no? I wouldn't want it to make me more hyper you know.

Also, I take Lialda so maybe that is affected my liver/kidney, besides that I take vit d, zinc, cysteine, lysine, thats it! Well, at least the levels were low. Im getting them checked in 3 weeks again.

Also, do you know a reliable place to get hair analysis done? Thanks!

Hi Ant... Here is what I found on www.drugs.com (an FDA approved site) regarding the side-effects of Lialda:

The most serious adverse reactions seen in Lialda clinical trials or with other products that contain or are metabolized to mesalamine are:

* Renal impairment, including renal failure

* Mesalamine-induced acute intolerance syndrome

* Hypersensitivity reactions

* Hepatic impairment, including hepatic failure "

"In two 8-week placebo-controlled clinical trials involving 535 ulcerative colitis patients, 356 received 2. 4 g/day or 4. 8 g/day Lialda tablets and 179 received placebo. The most frequent adverse reaction leading to discontinuation from Lialda therapy was exacerbation of ulcerative colitis (0.8%). Pancreatitis occurred in less than 1% of patients during clinical trials and resulted in discontinuation of therapy with Lialda in patients experiencing this event. " Source:http://www.drugs.com/sfx/lialda-side-effects.html

Regarding taking iodine for your problems -- I am wary of advising this now because I have no idea what the contraindications would be when taken with Lialda. So best to ask the endocrinologist about this.

You can get a hair analysis done at any naturopath clinic in your area -- its not expensive.

I think terrifying nightmares are usually a sign of being haunted. There may be entities that could be harassing you while you sleep. Maybe you were physiologically weakened and that allowed an opening in your psychic shield to these entities. By taking the selenium, it may have made your aura more stronger hence closing off some psychic vulnerability you had. Glad you had some success with selenium.

@Rsw: In my estimation, institutions which are funded by big pharma are going to exhibit a marked bias for "medication" and against "nutrition". This is obvious everywhere in medical practice as physicians want to no all supplements one is taking so to reduce interaction w/ "medication". From a ND perspective, one should always seek to maintain proper essential vit/min and adjust any medication from there.

A very reliable first stop for nutrition information, again, imho, is the Linus Pauling Institute. This article http://lpi.oregonstate.edu/infocenter/minerals/selenium/

addresses this finding, but notice the educational approach on the entire subject of Selenium as it relates to the human body.

I think it was the famous musician John Denver who saw several specialist for an infertility issue w/ no help, when eventually he found that his problem was simply a Selenium deficiency. This is that bias problem again.

Rsw, why don't you just eat a Brazil nut or two daily? You won't get too much selenium in that.

I read that study and was kind of nonplussed as well. But then I remembered how iodine supplementation can lead to problems if the patient is low on selenium as well as iodine. We run the risk of exacerbating another nutrient's deficiency when supplementing another.

Perhaps the selenium supplementation caused an already low level of chromium and/or vanadium to go so low as to cause diabetes, as these two minerals are used by people to treat their diabetes.

Thank you Timh, Mmsg and Nanowriter for taking the time to give me your input on selenium supplementation. You have given me several different paths to think about adopting. It's because of generous people like you that Earth Clinic is my absolute favorite site and I am thankful for finding such innovative and out of the box thinking on medical and other issues. The biggest hearts can be found right here. Thanks!

Regarding Earth Clinic's query about "Se" in someone's post. It stands for Selenium which is extremely helpful for those who have problems with their thyroid. By the way, I love this site and check it regularly. I've learned so much. Thank you!

To Wendy - I would question your source of colloidal silver? Were you tested and told you had toxic levels of SILVER in your body? You must have a bad source as colloidal metals DO NOT build up in your system and it is an invaluable healing agent. I took a tablespoon daily for 10 years and then the last couple of years have not taken it only due to finances. BUT - I have not had so much as a cold for 12 years since I first started taking it - and I used to get one or two bad colds every year.

I gave it to someone who had a flu and had been taking antibiotics for several days with NO change - in a matter of about 4 hours their flu was GONE. I have also over the years treated my pets with it (putting it in their water). I have given it to my cats when they were sick and I didn't know why - and fixed them up immediately. Another thing it is very good for - you never have to worry about eating some bad food - on the few occasions I did, colloidal silver cleared up the problems immediately.

It is a huge disservice to tell people not to use it - it is very reasonably priced and if properly made CANNOT build up silver in your body.