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In this new study, 60 mg/day of melatonin helped improve outcomes in patients undergoing CABG as discussed here :
https://link.springer.com/article/10.1007/s10495-024-02040-6
Here is a relevant quote from the study :
' TNF-α levels decreased in the MTG at T1(p = 0.034) versus PTG. At T2(p = 0.005), and T3(p = 0.04), TNF-α significantly increased in PTG versus MTG. Troponins significantly increased in PTG at T3 (p = 0.04) versus MTG. NF-κB levels declined at T1 (p = 0.013) and T2 (p = 0.0001) in MTG compared to PTG. IL-6 significantly increased in PTG versus MTG at T3 (p = 0.04). The QOR-40 score significantly decreased in MTG versus PTG. MTG had statistically significant decrease in DBP compared to the placebo group (p = 0.024). MTG had a statistically significant shorter intubation time than did the placebo group (p = 0.03). Melatonin 60 mg was well-tolerated without any reported side effects. Our findings suggested that melatonin could ameliorate myocardial I/R injury after on-pump CABG and that this outcome was essentially correlated to its antiapoptotic and anti-inflammatory effects. '
So the above results suggest that melatonin reduced major inflammatory markers TNF-alpha, IL-6, NF kappa b and lowered troponins, a marker indicating heart damage from a heart attack. Meanwhile, the placebo group had opposite and negative results of these parameters. Melatonin generated no side effects in this study.
This study is interesting because CABG these days is a common medical procedure and melatonin has a very good safety profile even at this higher dose of 60 mg/day with no side effects. Previously I wrote about the value of melatonin for promotion of cardiovascular health at the link below and the new study above shows that melatonin has very significant heart health value even when used in advanced heart disease situations such as CABG, stroke or heart attacks and as shown in other studies :
https://www.earthclinic.com/cures/melatonin-for-cardiovascular-disease.html
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