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In primary Sjogren's Syndrome (pSS), two of the most common symptoms are dry eyes and dry mouth. pSS damages the salivary glands (SGs), leading to dry mouth and melatonin helps protect the salivary glands from this damage, as discussed in this new March 2024 study :
https://pubmed.ncbi.nlm.nih.gov/38460474/
Here is a relevant quote from the study :
Melatonin had the potential to mitigate inflammation, oxidative stress, and apoptosis in SGs of pSS by inhibiting the IL-6/STAT3 pathway through receptor-dependent mechanisms. This intervention effectively prevented glandular damage and preserved functional integrity.
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