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Andrographis paniculata has been used in Eastern medicine for centuries. The immune boosting properties of andrographis have been researched extensively in clinical studies. In seven double-blind controlled trials, andrographis was found to be a safe and effective botanical for supporting upper respiratory tract health.In a study of 158 patients, a standardized preparation of A. paniculata dried extract administered for five days significantly decreased throat irritations and aided in drying nasal secretions. The active ingredient, andrographolide, has been found to modulate inflammatory response by inhibiting NK-kappa B.