Posted by Normared (Knoxville, East Tennessee, Us) on 05/03/2012
★★★★★
After a bad two-week long spell of sharp, needle-like pain in my feet I looked at this site for advice. At my next doctors appointment a few days later, I checked with him for his opinion, and based on that added ALA to my treatment (which was metanx pills he gave me last year). Within 24 hours of taking one 600 mg tablet of ALA the pains were down by at least 50% intensity, and now a week later they are almost completely gone. A few days ago, I also added a B complex, and plan on adding a B12 lozenge too.
My doctor - a foot doctor who specializes in neuropathy - had no problem with these 'additions', in fact he is the one who suggested B12 in a lozenge form, not a tablet. I'm now a strong believer in taking ALA B vitamins for those pains in my feet!
BTW: Bought my 600mg ALA tabs at GNC - they've got an amazing vanilla flavor and are a pleasure to take! I take 3 per day and a Bcomplex once a day.
Posted by Janet (Fernvale, Queensland, Australia) on 04/28/2012
★★★★★
I also swear by Turmeric for Neuropathy, but my understanding is it needs to be heated and taken in conjunction with black pepper for activation. If I have fresh Turmeric I simmer it for approx 10 minutes but if it is powdered making a tea with boiling water is another way to go, I add ginger, black pepper and agave to sweeten and it is a very pleasant drink. I have this drink daily and the pain relief properties are amazing.
Posted by Shrikant (New York) on 11/15/2011
★★★★★
Hello.... I had feet burning for a long time(2 - 3 years). Earlier to that I found my feet was paining a lot. I am diabetic for the last 30 years. Obviously it should be diabetic neuropathy. Recently I tried Benfontamine (fat soluble Vit B1) 200 mg twice a day alpha lipoic acid 600 mg Methylcobalmin (B12 variety) that aids the process of methylation. I found that the feet burning has been controlled substantially. I used to take alcohol in moderate amount. The day I take alcohol my feet burning erupts and the day I stop it goes away. I think alcohol has something to do with my feet burning and I have now decided to discontinue alcohol altogether! Let us see.
Shrikant
New York
Posted by K (San Antonio, Texas) on 02/10/2012
★★★★★
I belive my neuropathy is caused by a course of Leqavuin 2 years ago. It started with a numb big toe and spread out. I've taken b-12 patches, Alpha Lipoic, Lecithin, MSM, acupuncture, Bach remedies, NAC, but what feels like a cure:
This week
5 pieces of Turmeric juiced into my morning carrot juice, along with 2 packets of Liposomal glutathione.
I actually credit the Turmeric more than the gluathione, but the two in combination are alleviating all my numbness and prickling for the last 7 days.
Posted by Ellen (Arlington, Tx) on 09/22/2009
★★★★★
Alpha Lipoic Acid for Neuropathy
I have a pinched nerve in my back which causes peripheral neuropathy. I have been using ALA for almost 2 weeks now and my symptoms have improved I take 300 mg (time released tablets) twice per day.
Posted by Sharon (Sacramento, CA) on 12/03/2008
★★★★★
My mom has peripheral neuropathy not caused by diabetes. She complained every day and it had started to cause a persistant burning in her forehead also (a form of pn according to her neuologist) She now takes 300mg of alpha lipoic acid daily and no longer has the forehead sensation and feet are much less painful. She stopped for awhile and within weeks was complaining of the old symptoms. She resumed the supplement and symptoms abated.
Posted by Baldev (Mumbai Maharashtra India) on 06/17/2023 180 posts
May I request Art and any other poster to do the research on this subject. Because Neuropathy of non diabetic origin is quite rempent these days.
Thanks Baldev
Posted by Art (California) on 06/17/2023 2440 posts
Baldev,
I'll do that this coming week.
Art
Posted by Whisperingsage (Northern Ca) on 09/20/2020 45 posts
★★★★★
I've been using MSM for years to prevent gallstones and my neuropathy just continued on. My initial neuropathy was from B12 deficiency, which was from chronic diarrhea, which was from vaccine injury.
Posted by Joanne M (Vancouver Wa) on 12/28/2015
★★★★★
I had PN BAD in both feet. After several tests doc told me to stop the B vitamins. B6 in excess can cause PN. I quit the B vitamins and started taking Benfotiamine and after a month my feel are returning to normal! I can finally feel my feet and the tingling is almost gone. Thank goodness!!!!
Some people cannot metabolize B6 efficiently. I'd quit taking them asap.
Posted by Joanne (Vancouver, Wa) on 12/02/2015

WARNING!
I got Peripheral Neuropathy from an overdose of B vitamins! Be careful with them. They really messed me up. Vitamin B has been said to help with PN but if you get too much it can cause it. The tingling I was feeling was from too much Niacin also. Called the Niacin flush. Doc told me to go off of B supplements and within a few days my zapping was gone. It's been 2 weeks off of them now and all has recovered except I still have a thick feeling in the balls of my feet. I am now trying the ALA remedy and so far it is helping but it could be also that I am not on the B supplement anymore.
Posted by Megan (Usa) on 04/04/2016
B6 people!!! B6 toxicity is happening in small amounts all over the world!!
Posted by Hamza (London, UK) on 08/11/2014
★★★★★
My mum had severe pain, pins and needles, numbing, throbbing and tingling in her feet whenever she would try to sleep for about 20 years. I wanted to help her, so I looked it up online and found that vitamin b1 would help. Within a few days of supplementing with 1 vitamin b1 100mg capsule daily her pain is gone and she sleeps much better.
Posted by Bill (San Fernando, Philippines) on 05/01/2014
Hi Diane...In a study published in the BMJ in 2003 it was found that varying degrees of peripheral neuropathy, in the form of cryoglobulinaemia, commonly occurred in patients with Hep C. They found that 40 of 51 Hepatitic C patients had this form of peripheral neuropathy.
Peripheral Neuropathy in Hepatitis C
Although the numbers may vary, if you type "Hepatitis C neuropathy" in Google Search you will find many other instances and confirmations that this form of peripheral neuropathy commonly occurs together with Hep C as well as in other diseases like leukemia and pneumonia.
In other studies it has also been suggested that this form of peripheral neuropathy is caused by auto-antibody response arising due to a heavily stressed immune system because of the HCV factor. Nevertheless, cryoglobulinaemia is still referred to in medical research as an idiopathic disease.
idiopathic = completely clueless as to the real cause of the disease
Treatment of cryoglobulinaemia is normally entirely palliative(treat the symptoms) using analgesics and anti-inflammatory drugs, since there appears to be no apparent cure.
I also think that your liver doctor needs to open a book or go on a Hep C refresher course or perhaps she just needs to renew her dusty but outdated Standard of Care Manual.
Posted by Denise (Seattle) on 11/01/2013
Mama to many, Thanks you for the feedback. Interestingly enough, I have a friend that's a periodontist that had cancer and cured it by drinking carrot juice and nothing but for a month! He drank so much the bottom of his feet turned orange...but it worked! He got out of the Doctoring field because it's a "Crooked/unethical game they play to all people." He told me if I ever went to an emergency room and had full insurance coverage they would do every tesy available even if you had a hangnail...I have a neighbor who that happened to and she just had a sore wrist but they ran up an $8,000.00 bill with every kind of test possible..(MRI, CAT scan, full body Xrays, blood tests etc. etc. all stuff completely unrelated to her wrist.) my friend now has a holistic business for children in PA.
In any event, he's cured and I just may give carrot juice a try..even though neuropathy is my issue along with hep-c..Thank you again.
Posted by Bill (San Fernando, Philippines) on 04/16/2013
Hi Denise... Lack of Iodine in the body can cause cold hands and cold feet. Iodine helps to regulate and control the body's accomodation to hot and cold conditions via the thyroid gland -- especially at the peripherals of the body. So it might help if you supplement kelp or lugol's iodine to see if this helps your problem of feeling cold at the peripherals of your body.
Another reason for this problem could be because of your Hep C. Improving the liver's function thereby purifying your blood may also be helped by taking Milk Thistle(1000 mgs twice a day at mealtimes), Selenium(200 mcgs twice a day at mealtimes) and Alpha Lipoic Acid or ALA (300 mgs twice a day at mealtimes). ALA is a wonderful detoxer of poisons and is well known to help peripheral neuropathy problems in the body. Drinking Chanca piedra tea two or three times a day or taking 1000 mgs of Chanca piedra (twice a day at mealtimes) will also help you detox and repair your liver. I would also take Chlorella on a daily basis to help remove any heavy metals from your body.
You can also find other useful Hep C remedies here on EC:
BHT Remedy for Hep C
Berkson Therapy for Hep C
Ted's Lysine and Vitamin C remedy for Hep C
Posted by Ky Mama (Clinton, Ky) on 03/24/2013
I took the Burdock Root before meals. But I don't think it is hard on the stomach and could probably be spaced out any way that is convenient. Four to five 00 capsules is generally about a teaspoon. Hope that helps!
Posted by Ky Mama (Clinton, Ky) on 08/29/2013
Yes, it worked out to about 3 teaspoons a day. It would be fine to just take the powder in water. It has a mild taste. It is used for food in other countries. I hope it helps you as much as it helped me. God bless you! KY Mama
Posted by Denise (Seattle) on 08/31/2013
Ky Mama to many, Thanks you for the feedback... I don't think it's a good idea for me to take BSM as it is high in iron. I have hepatitis c as well as neuropathy... I've read iron will help the viris replicate... Maybe I should try it for just one day and see... Hmmm?... I believe the hep-c caused the neuropathy... I had stage 4 chirossis in july 2011 and at the exact same time my neuropathy surfaced... I believe the two are connected... I got rid of chirrosis in 5 months but my neuropathy is still here... I tried a product recently called Padma 28 and got severe headache ans swollen glands in my neck, which I still have.. I certainly will try burdock root and start low and increase... Interestingly enough I took Essiac tea for about a year and it didn't help my cramps. It has 4 herbs and one of them is Burdock... My guess is the burdock is a low dose in the tea.. Again thank you for the feedback and bless you muchly.....
Posted by Timh (Louisville, Ky, Usa) on 03/13/2013 2042 posts
Katie: According to our leading authority on Parasite disease, Dr Hulda Clark, we all have parasites or stages. For many people this isn't a problem, for others, however, it creates chronic diseases that do not respond to treatment with any significance. Parasites excrete all sorts of bacteria, funguses, and viruses as a byproduct of their metabolism. Heavy metals, or zenobiotics are also possible with you. Look a few yrs back in your life (recapitulate) and try to find any particular moment when you got out of your element (routine) and became "suddenly" ill. Something is dragging your immune system down.
First, do an herbal parasite cleanse, as well as any methods of general detoxification (info here on E.C.)
Second, boost your immune system by supporting your Thymus Gland. Here is a previous post I made for this: The Thymus gland is like the brain of the immune system as it is involved in both production and regulation of immune or white blood cells. Thymus function decreases significantly w/ age so any method to augment it is definitely recommended especially those suffering chronic infections. To boost the Thymus do these little exercises on a daily basis and significantly boost your immune power. First, use some type negative pole magnet (the side that sticks to metal) over the Thymus, which is directly between the lower neck and heart area; a common refrigerator magnet will do just fine; do this for approx 15 minutes. Second, do the "Thymus Tap" by making a fist and gently bump the T area a few times and wait a little then bump again several times daily. Thirdly, supplement Raw Thymus Glandular as recommended on label. " Also, if I might add, Zinc Lozenges will boost the Thymus.
Here is a link for Lyme Section: https://www.earthclinic.com/cures/lyme_disease.html
Hope this helps. Come back and update us how you're doing.
Posted by Whisperingsage (Northern Ca) on 09/21/2020 45 posts
If B12 deficiency goes on too long, it can be permanent.
Posted by Karen (Tampa, Fl) on 03/13/2013
Katie, Dice a whole lemon, skin and all then liquify it in a blender.. Strain if you want and put in glass... Add one tablespoon of X-virgin olive oil and one tablespoon of lecithin and drink everything either at once or spread out over the day... Also put more lecithin - up to 4 tablespoons in the drink if you want to... It is most important for nerves... Do this for one month... You will see improvement and maybe resolution.
Report back to this site if you are so inclined... God bless.
Posted by J (Ny) on 03/20/2014
Try r - alpha lipoic acid 300mg 3 x daily
Benfotiamine 500 2x daily
Acetyl l carnitine 2x daily
Methly b12 15000mcg sublingual 2x daily
B complex vitamin 2x daily
10000 iu vit d3 daily. Excessively lotion all affected skin twice daily since neuropathic doesnt sweat. Elevate feet at night above the level of the heart. Thick soft socks or footies
You can try the neuropathy oil they sell in cvs pharmacy, a tea tree oil neura.... Something like that sorry dont remember the name exactly. Stay away from alcohol consumption Forever! God bless you I will pray for you. J
Posted by Connie (Slc, Utah, Usa) on 03/01/2013
Hi Karen; The neuropathy is probably a painful result of vitamin B12 deficiency. Treatment involves high doses, even injections, and can take a long time to heal (up to a year). Treatment of B12 deficiency is life-long.
Neuropathy is one of the many symptoms of B12 deficiency, and skin pigmentation changes is another; hyperpigmentation, and/or hypopigmentation, for instance. (I bring this up because I remember a post about discoloration of the feet.)
Good Wishes
Posted by Timh (Louisville, Ky, Usa) on 03/03/2013 2042 posts
Karen: Assuming you do not know the exact cause of the Neuropathy, the nutritional trial method is your best treatment option. The R-Lipoic at maximum dose would be as close as you could get to I.V. Therapy. Also consider Magnetic Foot Pads or Insoles, they definitely help my Peripheral Neuropathy.
Have you been tested for Heavy Metals??? Maybe some detoxing would help also.
Let us know how your doing.
Posted by Oldriska (Prague, Czech Republic) on 02/01/2013
Hi Diane, I'd be a bit suspicious about treating neuropathy with water with salt and sugar. I have neuralgia in my face and have tried many treatments and read a lot on the subject of neuralgias/neuropathies. Sugar is not recommended for nerve pain and salt can increase blood pressure which conseqently can increase pressure on the nerves. I think if it was this easy to treat the condition there wouldn't be all the people suffering with chronic nerve pain. Still, if you give it a go and have good results with it I'd be only happy to hear your feedback and change my opinion! Take care, Oldriska
Posted by Lily (Kelowna, British Columbia) on 01/14/2013
★★★★★
Gluten-Free Diet for Neuropathy
Research ideopathic gluten sensitivity. I have had relief from kicking gluten from my diet!! I tried all the other stuff & got some relief BUT this was relief and it happened within days of being diligent about NO GLUTEN.
Posted by Lizette (Wi) on 11/07/2017
★★★★★
Lugel's Iodine is the best and most potent...be mindful it requires very little!
Posted by Al (Alvena, Sk., Canada) on 11/20/2012
★★★★☆
Just an update for everyone. I had to switch back to Lyrica from Cymbalta due to a negative reaction. After reading the the information from the top link from Tim in Eu I considered the information about ALA being used to remove free radicals from ALCAR therapy and came to the conclusion that they might be better taken together to get the best effect and so have tried it. I have had no issues from doing so and have gone back to my original dosage to find that I have less pain now at the lower dosage. Almost all the numbness is gone now and I only have pain in my toes. It is aggravated by the job I am doing but is still improving and it is at a level that I can tolerate so I will keep at it for now. It almost seems like too much ALA & ALCAR can cause a higher level of the frozen/burning/pins and needles type of pain in the same way that pressure/activity can aggravate the sensory nerves with this condition. I have found a 5 mg sublingual B12 in the AOR brand and just started using two per day with promising results.
Posted by Al (Alvena, Sk., Canada) on 03/02/2013
It is now six months since I started on ALA and four months since I went back to work. After about three months I hit a plateau where it seemed the improvement slowed down with all the supplements noted in my previous posts. I tryed the vitamin B12 at doses up to 40, 000 mcgs per day with some success and again hit a plateau. I stumbled across L-arginine, it is supposed to increase circulation, and added it to my regimen. I thought it would help by allowing more nutrients to get to my nerves but found that it actually improved things by making my feet feel warmer. I did some more research and found out that phosphorous is good for nerve health and went looking for phosphorous. I found it in a bone supplement with huge amounts of calcium included in it but tried it anyway. It is helping. I began to feel that something else was missing so I added in potassium and magnesium (at the same time) and am seeing beneficial results. The 'electric shock jolts' are now gone but I still have a small patch of numbness in the soles of my feet and a varying level of a burning sensation pain in my feet. I am not entirely healed yet but I am still improving and am working as much as 76 hours per week without issues. I have discontinued Lyrica as it no longer helps the tinnitus. I have also noticed that the timing of my medication/supplements is not critical any more. I take everything in the morning after breakfast and selected ones after supper which is usually about 15 hours later. I also find that if I move my toes around when they get painful that the pain is reduced fairly quickly now. My doctor informed me a couple of weeks ago that ALA is going to be available by prescription in Canada very soon for neuropathy.
My experience is telling me that we all need to try everything available and must utilize all of the vitamin and mineral supplements that can support nerves to promote healing in the quickest manner possible. I can now see that I will completely recover from my chemotherapy induced neuropathy in spite of being told by my neurologist that "where it is a year after chemo is as good as it will get". I am now 37 months from having started chemo and am still improving.
As I am now working full time and long hours, if anyone has specific questions for me, you may contact me directly at gustafsonal (at) hotmail {dot] com. Thank you. Al
Posted by Art (Vancouver Bc, Canada) on 09/24/2013
★★★★★
Dear Al.
I am so glad to hear about your success with the ALA. I have had great success with it as well with the burning sensation just above my knees and pressure aches on both wrist. I was taking 2x250mg with every meal and then I discovered I only need to take it at noon and supper. Without this my life would be hellish painful. It was your posts that got me started on the ALA. I did try the R factor ALA with little success.
Art.
Posted by Al (Alvena, Sk., Canada) on 11/04/2012

ALA will make your heart race if you have overactive thyroid problems and/or are on thyroid medication(s). You should maybe get your thyroid gland checked out and that might even fix your neuropathy. Most ALA labels caution about using it with thyroid medications.
Posted by Al (Alvena, Sk., Canada) on 12/02/2012
★★★★★
3 months now since I started ALA & ALCAR and I have been working full time - just around 60 hours per week in the log book. I am quite surprised at how well I am doing. At the end of the first week I was exhausted, partially due to icy roads on days 4 & 5, and thought I would need to take a break midweek for a few weeks but kept at it and didn't need to. I still have a bit of pain, tingling and numbness but it is still receding. I expect that it will take many months to completely recover if I ever do. I am maintaining my supplement regimen but have reduced the Lyrica by 50% a week ago, resulting in an increase in the pain level, and have also reduced the amount of Diamicron MR that I am taking by 50% as well due to the blood sugar getting too low, a good indication that the curcumin and Diamicron MR are actually healing the pancreas as I am healing the neuropathy. Maybe the two are complementary. I saw another acquaintance today that I hadn't seen since June and he didn't recognize me due to my hair colour returning. Onwards and upwards.
Posted by Al (Alvena, Saskatchewan, Canada) on 03/04/2015
★☆☆☆☆WARNING!
Another update. I recently had surgery to remove the right lobe of my liver. This was due to matastatic colon cancer and as a result my blood pressure has gone up resulting in other problems including reduced energy and increased neuropathic pain. I noticed that when I had something sweet to eat like jam, cake, candy, etcetera that the neuropathic pain was reduced substantially so I started experimenting. When doing anything slightly strenuous my blood pressure and sugar would drop and my pulse would go way up so the first thing I tried was leaving out the diamacron and metformin. This allowed the sugar to increase and gave me back my energy without my blood pressure and pulse being significantly affected, but the sugar went too high so I added the metformin back in. Big surprise!!!! The neuropathic pain went way down, more than eating something sweet made it go down. As a result I typed "diamacron" into google and clicked on "diamacron side effects" and found out that it causes neuropathic pain, conflicts with metformin, is not supposed to be used if you have liver problems, are having or recently had surgery. None of this was covered in the pharmacy information sheet I was provided. The warning is not about alpha lipoic acid, but rather it is about the diamacron prescription medication and what it does. Eliminating it has made a huge difference. I have not as yet tried the nicotine but will be soon. Al
Posted by Tlkleen (Halifax, Nova Scotia) on 02/10/2013
My husband has a rare disease called Tangiers. It causes neuropathy mainly in his limbs, but has lost feeling all over. He suffers from alot of pain. He is getting ALA treatment from his naturopath. They are starting a new treatment that involves a new natural med that will be administered before the ALA to help the body absorbe it. They say he will notice a difference with in 30 days. Fingers crossed!
Posted by David (Westford, Ma) on 04/29/2012
★★★★★
I was diagnosed with peripheral neuropathy in November, 2011. The excrutiating burning on the bottoms of my feet had gotten progressively worse and I really thought my days were numbered. The last thing I would ever want to do would be to go on disability but it seemed like that was where I was headed. I have done everything to help myself. Mind/body 8 week course to learn to live with chronic pain, accupuncture, diet, meditation, yoga and more. Three days after I started ALA I thought my pain had started to reduce.
Now 6 weeks later except for minor discomfort now and then I don't think about my feet 24/7 anymore. I actually drove myself to the Museum of Fine Arts and walked around last week for a couple of hours forgetting that a few weeks prior I never could have done that. I feel blessed to have found ALA if this is why I have gotten better. I have also stopped all statins as I tried just about every one of them. I also discontinued amlodipine as the swelling it causes of my feet I was sure was aggravating my pain. I now take 900mg. Per day and wonder if that is too much? I have read many research articles on ALA and they seem to agree that IV ALA does help neuropathy. There don't seem to be any conclusive studies on oral ALA. I am looking to try and find whether ALA can actually cure Neuropathy or if you need to keep taking it?
Posted by Ms (Honolulu, Hawaii) on 02/13/2012
★★★★★
I also took the same Bs as Shrikant (the fat soluble B 12 & Metacobalin) and my neuropathy in both feet that I had for a few years got better THE NEXT 24 hours I could tell - a difference for the better. I am now still on the fat soluble Bs and it has been 1 1/2 years now. The tingling, the extreme sensitivity, the sudden jerking jolts of what felt like electric shocks within my feet are all gone.
Only thing is lately, I have noticed a tightness appearing and I cannot bend back my toes towards me comfortably. Don't know why...
Posted by Maria (Gippsland, Australia ) on 02/13/2012
Hi Ms (from Honolulu), If it feels like that they might cramp if you move them any further then I would suggest magnesium. Works for me if my toes feel like or do cramp. Even if it is not cramp it would be worth trying some mag.
Posted by Janet (Kendal, U.k) on 08/19/2011
★★★★★
My partner also suffered with PN due to his diabetes, he was already taking ACV and CO, this seemed to help his blood sugars , but not the pain.
However literally after the first dose of MSM he got instant relief, he continues to take it but rather on an if and when need basis. Also we read that LECITHIN can help, which he also takes, daily, due to a relative short shelf life. He is so much better.!!! Oh I hope this helps , any one that suffers this puts up with so much.:(.
Posted by Al (Alvena, Sk., Canada) on 09/16/2012
Kate, I have noticed that if the pain is less when you wake up in the morning that it is often an indication of too large a dosage of something and so would reduce one item at a time until I found the culprit and then put everything else back to normal dose and reduce or eliminate the one that caused the problem. When things get worse we need to experiment a bit. Al
Posted by Liz (Boston, Ma) on 06/25/2011
★★★★★
Months ago, I added Alpha Lipoic Acid (100mg 3x per day) to my daily supplements for its antioxidant properties. After about a month, I noticed that the intense foot burning and pain I'd been experiencing for years was GONE! Yay!!
Just an FYI - the dosage I take is a low one (300mg/day). Those suffering with different types of neuropathy could go as high as 800mg/day.
Posted by Bess (Calgary, Alberta, Canada) on 10/26/2011
Hi Monique - You may want to increase your Vitamin B12 (Methylcobalamine - take sublingual tablets) and ensure you take a Vitamin B Complex as well. I've read that Vitamin B12 protects the sheathing surrounding nerve cells and can promote regeneration and growth of nerve cells.
Also, be tested for Vitamin D deficiency (mercola.com or Vitamin D Council have lots of info on this). If you do an Internet search for "vitamin D deficiency neuropathy" you'll find lots of information suggesting you get your Vitamin D levels up. Good luck!
Posted by Juliamary (Johannesburg, South Africa) on 12/09/2011
People who have burning feet - do you realise that it can be caused by too much caffeine? Caffeine prevents the absorption of vitamin B, so that even if you are eating well and having vitamin B supplements, that vitamin B is not being absorbed. The reason why some sufferers are not getting any better when they take various remedies may be because they are drinking eight cups of strong tea or coffee a day! Give it up and see the difference it makes.
Posted by Al (Alvena, Sk., Canada) on 09/16/2012
Gatordennis, I have used grapeseed extract, curcumin (an extract of turmeric), gabapentin/Lyrica, alpha lipoic acid, acetyl-l-carnitine, hydromorphcontin and morphine. Nothing has worked as good as ALA and ALCAR although grapeseed extract reduced the need for narcotics ALA and ALCAR ELIMINATED THE NEED FOR NARCOTICS. I still use Lyrica but hope to be off of it soon and just started using benfotiamine. Just a note to those with gluten intolerance, my wife was diagnosed with celiac disease and I had just heard about an old variety of wheat that could be tolerated by celiac's. I bought some whole grain flour made from "RED FIFE" wheat and six months later she had no further indication of celiac disease. Seems the old varieties of wheat have different composition of glutens/proteins that make a difference. My supplier tells me that "MARQUIS" wheat is quite similar and is showing the same results. Al