Melatonin Protocol for COVID-19

1- The only side effect I've noticed till now is that whenever I bump into something I get a big hematoma afterwards. Have you noticed this on yourself too?

2- So I assume blue light glasses are not necessary while we use our laptops in the evening?

thank you again for your very informative reasearch, God bless you!

Paola

https://link.springer.com/article/10.1007/s00018-022-04390-3

Here is a relevant quote from the study:

>>> ' In conclusion, we disclosed ACE2 as a new binding target of melatonin, which leads to allosteric negative modulation of the spike/ACE2 interaction. This effect on the SARS-CoV-2 entry receptor function of ACE2, combined with the inhibition of NFKB expression and endogenous ACE2 expression in endothelial cells, is most likely the predominant mechanism for impaired SARS-CoV-2 brain invasion by melatonin and its derivatives. ' <<<

An important point of this study is that melatonin binds to ACE2 receptors interfering with the ability of the SARS CoV-2 virus to dock on ACE2 receptors and melatonin does this without serious side effects.

Art

By the end of the second day of treatment, she reported being symptom free. She said she still intends to continue HDM for another 2 to 3 weeks to try and prevent long term damage as well as Long Covid.

Unfortunately, my friend has herself gotten Covid-19 as confirmed by 3 rapid tests all confirming positive for Covid-19. She had given her melatonin to her friend so she is using Ivermectin which she reports is keeping her symptoms mild at this point, day 2. She said she will update me when she knows more.

Art

I reminded my friend that Dr. Neel was using 1 mg of melatonin per kilogram of body weight. She said her friend weighed 170 pounds so that worked out just over 77 kg. She told her friend to take 80 mg of melatonin per day in 4 divided doses. Either her friend misunderstood or my friend did not say it correctly as her friend took 80 mg of melatonin every 6 hours to start with which equals 320 mg of melatonin per day! I got a phone call from my friend this morning telling me what her friend had done and she said she suffered no ill effects from that dose. She further said that her headache was down to a 2 and all of her body aches were gone.

I explained to my friend that the dose her friend used was more like the dosing that they were using in Manila. In any case, she told her friend that Dr. Neel was only recommending one fourth of the dose she had taken, so her friend told her that she was going to go down to a 90 mg per day dose in 3 divided doses of 30 mg each dose or 30 mg every 8 hours. Her friend told her that she was feeling so much better after taking the melatonin and it was not causing her any ill effects that she could tell. She further said that she will continue the 90 mg per day for at least 2 weeks or possibly 3 weeks to try and prevent Long Covid.

Art

She is nursing her four month old baby. I had her take 20 mg of melatonin 4 times a day. She had never taken melatonin before. She was surprised that it did not knock her out. It did not have a negative effect on her baby (who is also sick.) It did not hinder her ability to take care of her little one.

This is not prescriptive - just one person's positive experience. Happily, she is feeling much better today and still taking melatonin.

~Mama to Many~

Adults—100mg of melatonin daily. Take 20mg 3X daily & 40mg at bed time.

Children—Most don't need the melatonin. Those who have a fever or cough use: Age 0-2 yrs take a dose of 1-2mg daily 4X daily, if they need it. Once melatonin is given the fever usually goes away in 30 minutes after a dose or two.

Children—2-6 yrs Give 20mg daily with a 2-5mg 4X a day.

Children— 6-12 give 40mg daily with 5-10mg 4X a day.

Children—over 12 yrs give same dosage as adults.

Dr Neel has successfully treated patients with Anti-Depressant (SSRI) Fluvoxamine which also treats OCD, I don't know the dosage, however it should be short-term due to dangerous long-term side effects. Short term would not be addictive. To learn more about Dr Neel Google: Dr. Richard Neel & Melatonin. Dr Neel has 39yrs experience, specializing in: Internal Medicine, Emergency medicine, Aerospace medicine. Tel: 830 538-3550. Dr Neel further stated that he does use vitamins also, I just don't know the Dosages: Vit A, Zinc, Vit C, Vit D, Melatonin & Virgin Coconut oil 15cc 3X daily. Please forward to family, friend and others.

Here is a link to his update :

https://devinenews.com/dr-richard-neel-encourages-forget-about-sleep-read-the-research-on-the-anti-inflammatory-anti-oxidant-and-immunomodulatory-side-of-high-dose-melatonin/#more-25220

He also mentions again that he will talk with any and all doctors who would like more details on his high-dose melatonin protocol.

Art

I haven't updated this thread in awhile and now seems like a good time to do that. This very recent (June/2021) human study (RCT) shows that even a relatively low dose of melatonin (9 mg) divided into three doses throughout the day, reduces symptoms and speeds recovery in hospitalized Covid-19 patients. Here is a link to the full study which seems very impressive considering the very low dose that was used in these hospitalized Covid-19 patients. Keep in mind that Dr. Neel is using a dose of 1 mg of melatonin per kilogram of body weight, which is much higher than the 9 mg dose used in this study. In an 80 kilogram person ( 176 lbs), 1 mg per kg would equal a daily dose of 80 mg in divided doses.

https://www.sciencedirect.com/science/article/pii/S0188440921001417?via=ihub

Some of the highlights of this study:

1. Nobody died in the standard of care group or the standard of care plus melatonin group.

2. Meantime to release from the hospital was 8.15 days in the standard of care group and 4.65 days in the standard of care group plus Melatonin. (p-value = 0.021)

3. Patients in the melatonin group showed a return to baseline health sooner than control patients (15.09 ± 8.69 vs. 29.60 ± 21.12; p = 0.004).

4. There were no adverse events in the melatonin group.

5. Labored or difficult breathing (dyspnea) was significantly less in the melatonin group. ( p-value = 0.049)

6. Fatigue was significantly less in the melatonin group (p-value - 0.02)

7. Cough was significantly less in the melatonin group. ( p-value = .045)

8. The inflammatory marker CRP was significantly lower in the melatonin group (p-value = 0.045)

As you can see from these results melatonin plus standard of care was significantly better than standard of care alone. The downside here is the small size of the study group, but this still tends to confirm the very good results that Dr. Neel has reported in the over 1000 Covid-19 patients he has successfully treated using a significantly higher dose of melatonin (1 mg kg/bw/day) than this study which used just 9 mg/day. This is the first melatonin / Covid-19 study (RCT) that I have seen completed.

The Manila study has not completed yet, but that is an important study because they are only treating patients who already have Covid-19 pneumonia.I know I have said it before, but I am going to keep saying it, please don't throw your melatonin away just because you have been vaccinated! If the virus continues to mutate rapidly as it has shown it can, this is a good reason to keep melatonin on hand, even if it makes you sleepy the next day. Getting any rest is useful in a disease that is noted for causing sleep problems. People who have been vaccinated still have gotten Covid-19 and died.

Art

In any case, the reason I started writing was for the long term effects that I felt certain would become a problem in short order and it appears that time has arrived where patients who have supposedly cleared from the infection are having longer term health effects and these effects are now being reported and written about. Here is such an article that describes these multiple health issues that are now cropping up months after patients have supposedly recovered.

https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/coronavirus-long-term-effects/art-20490351

This problem is becoming so common that they even have names for it now such as "long haulers" or "post Covid-19 syndrome". In my opinion, melatonin is still relevant in trying to deal with these health issues which doctors have little experience dealing with, just as when Covid-19 first showed up, so if you are thinking they will be able to help with these symptoms, you may be very disappointed.

Keep your melatonin handy!

Well, last night at 8:00pm I started feeling off with pain in my chest, shoulders, back and upper legs. By 9:00pm, I was having severe chills and decided to take my daily melatonin a little earlier than normal, but I also decided to bump my dose up to around 125 mg and immediately went to bed. I put 4 blankets on and still felt cold so I pulled the blankets over my head to try and warm up faster, but when I put my face under the covers, it felt sort of like when you open up an oven door when you have had a turkey cooking for hours and that heat hits your face, so I pulled the blankets back down to uncover my head as I clearly had a fever, but was too cold to get up and take my temperature. I slept restlessly and each time I woke up, I felt worse with more pain in my joints, shoulders, legs and my hands and fingers felt like I had severe arthritis. My chest and back hurt even more than earlier and I could not take a deep breath without significant pain. I can say with complete certainty, I have never felt anything like this before. I also noticed I was getting little indications that my legs wanted to cramp up, but I could not get myself to get up and get the mag oil spray from the bathroom, I was just too cold!

I woke up at 8:00 am and with the time change, that would have been 10 hours since I first noticed I was sick. In all of my life, I have never had a cold or flu come on so quickly as I felt perfectly normal at 7:00 pm last night. I finally got up at 9:00 am and had a lot of congestion in my chest and surprisingly, for me, was able to cough most or all of it up. Usually, when I have that amount of congestion, it means I am going to be coughing for a month or longer. I decided to take a long shower and during the shower, I noticed that I felt almost normal except for the chest pain when I would try and take a deep breath. By the time I got out of the shower, I felt really good, but I decided it might be better for me to go back to bed rather than go for my walk.

I don't know for sure that this was covid as I had no test, but I feel as certain as I can that it was. I've never had symptoms quite like these before and the arthritic feeling hands is an absolute first. Sitting here typing, I also notice that it no longer hurts to take a deep breath and I feel normal! No more pain in my joints, no more chest pain, no more back pain, and no more congestion!

If this is covid, I will say that melatonin does not seem to prevent it, but neither does the vaccine. My understanding of the vaccine is that you can still get covid except it is supposed to be milder and not life-threatening or very similar to melatonin.

I am taking 20 mg doses throughout today and will likely continue that for possibly a week and then go back to my regular night dosing. I had previously mentioned that you should not throw your melatonin away just because you get a vaccine and I still feel that way because if you do get covid after being vaccinated, melatonin if used right away, looks likely to make that covid infection even milder.

I am glad I found Dr. Neel and his melatonin protocol because only having to put up with covid for 12 hours is wonderful! I think it is worth mentioning that I was not taking vitamin C or D, lysine, iodine or quercetin. I was taking zinc though.

I will update if things change as I know I will carry this virus for at least a week or more so I will stay on top of my melatonin dosing. Dr. Neel did mention that melatonin could work as a stand alone treatment for covid and my experience tends to confirm his statement.

I am not aware of any other treatment for covid that can reverse it so dramatically in just 12 hours!

Although there is so much more I can write about melatonin, I am only going to write one more post about it on EC because I think people just get tired of hearing about melatonin, no matter how many health issues it can be useful for.

Art

I am happy to report that I and my family are on the other side of Covid, at least til our immunity wanes.

We were doing a variety of Coronavirus preventatives around my house. My husband and I have taken coconut oil daily since last March. My husband and daughter have taken astragalus root that whole time as well. We take vitamin D intermittently, and even in winter my husband and kids get lots of outside time. I have been taking 15 mg of melatonin at night for quite a while.

Then we got Covid.

None of us had a cough. Several of us lost sense of smell. Adults had significant fatigue. One child had a fever for one day. Several of us had sinus burning pain and eye pain. Headaches were common. I never registered a fever but felt flu like for a couple of days.

At the very first sign of illness, especially since we realized we had probably been exposed to COVID, I put everyone on the appropriate amount of melatonin (1gm/kg body weight every 24 hours, divided into four doses.) We also took 50 mcg of zinc, 1-2 grams of vitamin C, vitamin D and 2 quercetin capsules. We ate a lot soup and drank tea with honey. Appetites were not amazing, so I just focused on fluids. I had just gotten an amazing deal and stocked up on organic orange juice, too, so that was handy. Everyone rested as much as needed.

We did use some tylenol, ibuprofen and alka seltzer (never at the same time! ) for fever and aches. Alka seltzer seemed to work the best but I did NOT give it to children. Covid is new and aspirin has a history of causing Reye's Syndrome for some children with some viruses (like flu and chicken pox.)

It may be my imagination but I think I could feel the melatonin wearing off. When I was close to redosing time I would notice that I was feeling worse. I did take an extra dose or two in the middle of the night sometimes.

My mother in law, who is in poor health and lives with us, never had any symptoms. I gave her the same protocol that we took ourselves, in hopes of nipping it in the bud if she began with symptoms, which she never did.

I had some concerns about high dose melatonin (HDM) and its blood thinning properties. I am a bleeder because I have chronic low platelets. I didn't have any bleeding trouble with the HDM. My 9 year old is prone to nosebleeds but they did not increase in frequency during HDM. I don't recall him having any at all during that time. My mother in law is on xeralto and didn't have any trouble with HDM. This is descriptive though, not prescriptive.

While astragalus, melatonin, and coconut oil were part of our preventatives, they didn't prevent the disease. But perhaps they made symptoms lighter? I don't know.

I do think the earlier treating any illness begins, the better. It seems the viruses might get less of a foothold.

I think an over taxed immune system puts one at greater risk for getting a bad case of anything. Good nutrition, stress management, enough sleep, fresh air and exercise are all important for that. But honestly that can be really difficult for many people to accomplish. I'm just making an observation.

I have known some hale and hearty people get seriously sick. A naturopathic local doctor who was doing tons of preventatives and being super careful still got covid and got pretty sick.

I don't think there needs to be guilt associated with getting sick, for some failure of preventatives. We are humans and sickness happens to most everyone. When we are sick sometimes we have time to regroup our priorities, read a book we have wanted to read, and then take care of others when we are well.

At the end of the day, I am thankful we made it through relatively unscathed. I would use the same remedies again.

This is only one story of so many covid stories. It isn't a recommendation for anyone, but a “this is what seemed to work for us” story.

~Mama to Many~

It has already been recommended that melatonin dosage should be 1 mg/kg/day by Dr Neel. But, in the following research study, it is recommending 8 mg/kg/day divided into 5 sub-doses for COVID-19. The research study below also surprisingly says that melatonin at 8 mg/kg/day is "in the ranges used to treat septic patients clinically and is devoid of any adverse effect; thus, it is safe".

See below:

https://doi.org/10.32794/mr11250062

I find that dose of 8 mgs/kg/day very interesting. That also tells me that melatonin is very safe indeed at just 1mg/kg/day.

I've also found 12 research reviews on PubMed assessing and strongly recommending melatonin as a protocol for COVID-19 patients. These studies are all begging for permission from the FDA for melatonin to be studied for use in US hospitals. But the FDA/NIH are still not interested in doing the necessary research to prove that melatonin works against COVID-19. What's more, the FDA has known about melatonin's usefulness against COVID-19 since April/May 2019 when Dr Neel and others loudly informed the FDA of its hugely beneficial effects. I guess the FDA might be thinking that a successful, simple and cheap COVID-19 therapeutic like melatonin at this time might well hinder the ongoing vast sales of western vaccines all over the world. After all, if you have a successful and cheap natural therapeutic like melatonin that can revert your COVID-19 to ordinary, harmless flu then we wouldn't really need those vaccines. Right?

I also increased my vitamin d, c, and zinc intake daily as well.

Before I knew I had the virus, I had a pretty bad headache, a bit of a fever, and had some chills and heat flashes. My stomach was slightly bubbly as well. That was the first 2 days. By the afternoon of the second day I found out I had covid. So that is when I started taking megadoses of melatonin. My headache and fever started to leave.

The next morning, I woke up virtually symptom free. I could feel it just a little bit in my lungs and would occasionally cough up a little bit of phlegm but that was it. I continued with megadosing melatonin and taking extra c, d, and zinc for the next 2 weeks or maybe a little bit longer.

Then I tapered everything down gradually until I got back to my normal routine. Now I just take 20-30 mg a night before bed. I really believe that the melatonin increase basically made me asymptomatic almost immediately.

I used several different brands of dissolvable lozenges that were between 2.5 and 12 mgs a lozenge.

Thank you for coming back and giving this update as it is useful for any of the members who may get Covid.

Your results pretty much mirror what Dr. Neel has seen in his over 1,000 Covid-19 patients. Once full dosing is initiated, improvements are generally seen to begin the very next day. In the symposium he recently attended about using melatonin as a treatment for Covid-19, the doctors who attended were asked what if any dose may act as a preventative. Their answer was that is not yet known about melatonin, but they felt that if there is a dose that may act to prevent Covid-19 from getting started, it would be 20mg minimum.

Thank you again for your update, Jacob!

Art

Sunday 6pm 1st dosage of melatonin for us both. 20mg.
Took a second dosage at 1am. 20mg.
Another at 7am. 20mg.

I have been able to wake up a few times to go check on him. Tested his oxygen level and temperature. Normal.

I don't feel anymore sleepy than I do when I take 10mg. I had stopped talking melatonin last week because it's been giving me headaches. We had been taking it regularly. Natrol brand, 10mg time released. Husband had not stopped taking it. I currently feel just a light pressure (nothing terrible). Decided to drink some coffee and type this up.

I plan to continue 20 mg melatonin for us both at noon or 1pm today.
Oh! I've also been boiling water on the stove on and off all day with drops of Eucalyptus oil. We live in a pretty dry climate and with the heater running sinuses get really dry.

Art, I hope to keep updating. Let me know if you have any comments/ suggestions/ questions. Thanks for all the information you've provided!

Generally, he uses a dose of 1 mg per kilogram of body weight, but other doctors are now reporting going as high as 6x higher than Dr. Neel, by using up to 6 mg per kilogram of bodyweight! Overall, this is the best update yet and is quite informative because Dr. Neel attended a symposium of melatonin researchers and doctors who shared their information that they have gathered over time in the treatment of their patients with HDM. Even Dr. Castillo who is involved in the Manila study of HDM in Covid-19 patients who also have pneumonia. His team is doing the world's first randomized, placebo controlled, double blind study of HDM to treat Covid-19 patients. Dr. Reiter also spoke at the symposium as did Dr. Brown of Canada talked about intravenous melatonin because oral melatonin is known to be absorbed at only 3% to 15% of the dose taken while intravenous melatonin has much higher bioavailability. Dr. Castillo also mentioned a "maintenance dose" which many people are wondering about. The general consensus of the doctors who spoke at the symposium was 20 mg /day.

There was more to the update, but this was clearly the most informative and exciting update yet! Here is a link to the article :

https://devinenews.com/dr-neel-introduced-as-worlds-leading-expert-in-treating-covid-19-with-melatonin-clinically/#more-21819

Art

My question is how long do I continue to use the high dosage? From reading through the information you provided, I'm thinking to reduce dosage and see if symptoms return or worsen? At first, I thought I should stay on it for a minimum of two months. Any clarification or thoughts will be appreciated.

Shout out to Earth Clinic for being Earth Clinic!!

Trump always talked about how hydroxychloroquine was the solution to the problem, but he is not taking it! Nope, he's taking melatonin! ABC news just reported that.

Does anyone besides me find it odd that his administration never once mentioned that melatonin might be useful to fight Covid-19 and yet it is what they are giving him???

Art

Here is a link to the brief article:

https://devinenews.com/hooker-87-beats-covid/

Although it is just one case, 87 years old is a definite high risk case and he survived with High Dose Melatonin, along with vitamin D, zinc and vitamin C. Melatonin has shown synergy with these vitamins in recent studies. These four supplements are noted for having very good safety profiles and are all commonly available over the counter and are inexpensive. Simple, easy and effective and can be started earlier than the drugs being prescribed for Covid-19 in most cases.

This bodes well for the elderly!

Art

Here is a link to the latest article :

https://devinenews.com/lytle-area-facility-fights-back-quickly-as-covid-outbreak-strikes/

Art

One thing he didn't mention is the number of patients he has treated as of today(8/26/2020). The last time he mentioned the number, he said over 400 patients treated. He still not has reported any deaths as of this update. Here is a link to the update:

https://devinenews.com/masks-to-melatonin-how-it-works-why-it-works/

Art

https://www.docwirenews.com/abstracts/clinical-trial-to-test-the-efficacy-of-melatonin-in-covid-19/

Art

Of note related to this story is that 4 to 7 year olds are at or very near the peak of natural melatonin levels seen in humans suggesting that melatonin can not prevent infection, but it can apparently reverse it in short order based on this and many other reports! This could be useful information for all of those people who have kids or grandkids! Here is a link to that article :

https://devinenews.com/local-4-year-old-battles-103-9-fever-days-after-dad-tests-positive-for-covid-19/

Art

Since his patient load has increased very considerably, so has his knowledge and understanding of the use of HDM (High Dose Melatonin) in Covid-19 patients. This seems like one of his most informative updates so far!

Dr. Neel is now seeing patients who are in multiple higher risk categories and treating some of them is no walk in the park. Dr Neel is now using even higher doses of melatonin in these harder to treat patients at dosing that is closer to what Dr. Shallenberger uses in almost all of his non cancer patients and similar to what Dr. Reiter has used in some of his studies. Dr. Shallenberger uses much higher dosing in his cancer patients though.

Dr. Neel also mentions that he is now seeing many more young patients than in the previous 3 months. He also mentions that people with asthma are having a harder time with Covid-19 than his patients who don't have asthma. He is also seeing more young patients who are developing gastrointestinal issues. He does not mention any deaths in this latest update.

He also mentions that he is seeing at least one strain of virus that seems to be more virulent. The information he includes with this latest update does not seem to bode too well for the supposedly soon to be available vaccinations, if the virus is mutating significantly. Here is the link to this latest update:

Art