★★★★★
Yes, melatonin has shown in multiple studies that it can be quite useful in some people who have the chronic and painful disease, Fibromyalgia!
I was noticing that in the EC section listing remedies for Fibromyalgia that melatonin is not listed, but it should be because studies show that melatonin can ameliorate depression, anxiety and pain while lowering inflammatory and oxidative stress levels in people with Fibromyalgia! It also improved quality of life test scoring as well as mood.
According to these studies, melatonin is shown to do this at a relatively low dose of just 3 to 15 milligrams per evening, but it leaves one wondering if higher dosing might do even more?Melatonin has a fairly good safety profile and considering the limited benefit and considerable potential for side effects with standard Fibromyalgia drugs like steroids and antidepressants which come with the potential for a grocery list of potential for side effects, melatonin seems worth discussing with your doctor to find out if it is safe for you in your particular circumstances and if it will be compatible with all meds that you are currently taking.
In this first study, they used melatonin at 3,6,9,12 and 15 mg per evening and best benefit was seen at 9,12 and 15 mg in terms of a significant reduction in pain, anxiety and morning cortisol levels. Here is a link to the abstract, but the full study is a pay per view and I had to look at the study to see some of the particulars that were not reported in the abstract:
https://pubmed.ncbi.nlm.nih.gov/30415563/
This next abstract is more of a meta analysis that confers benefit from melatonin supplementation for Fibromyalgia patients:
Melatonin in the Treatment of Fibromyalgia Symptoms: A Systematic Review - PubMed
This last study shows melatonin to be more effective at pain relief than Amitriptyline.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119581/
Art
