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BIRM comes from the plant Kalanchoi gastonis-bonnieri. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356655/
There are three plants that belong to this group called Kalanchoe:
1-Kalanchoe-daigremontiana
2-Kdalanchoe-gastonis
3-Kalanchoe-pinnata.
One of the constituents of the kalanchoe-pinnata is bufadienolides which has the following effect on cancer: Pharmacology
The Bufadienolides in the leaves have antibacterial, antitumorous, cancer preventative, and insecticidal actions. These isolated compounds isolated include bryophillin A which showed strong anti-tumor promoting activity, also included are bersaldegenin-3-acetate and bryophillin C.
Bryophyllin compounds have marked anticancer therapeutic value against cancer cells. Bersaldegenin-1,3,5-orthoacetate inhibited cancer cell growth on several cancer lines.
https://tropilab.com/kalanpinnatatincture.html
References:
"The above presentation is for informational and educational purposes only.
It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage."
https://herbpathy.com/Uses-and-Benefits-of-Kalanchoe-Pinnata-Cid1161
https://www.bimbima.com/ayurveda/medicinal-use-of-patharchatta-or-kalanchoe-pinnata/1369/
http://cancerending.blogspot.com/2014/07/kalanchoe-bad-weed-that-cures-cancer.html