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Study highlights role of glutamine in absence of glucose in growth of B cell tumor.
Cancer cells have been long known to have a "sweet tooth, " using vast amounts of glucose for energy and for building blocks for cell replication.
Now, a study by a team of researchers at Johns Hopkins and elsewhere shows that lymph gland cancer cells called B cells can use glutamine in the absence of glucose for cell replication and survival, particularly under low-oxygen conditions, which are common in tumors.
Writing in the Jan. 4, 2012, edition of Cell Metabolism, Anne Le, M. D. , and a team of investigators collaborating with the Johns Hopkins Brain Science Institute, say the finding is critical for developing innovative cancer therapies because it offers "proof of concept" evidence that curbing the growth of B cell cancers can be accomplished by inhibiting a glutamine enzyme called glutaminase.
Le notes that although little is known about glutamine's role in the growth of B cell cancer, the amino acid circulates in the blood at the highest level among the 20 amino acids that do so.
The tricarboxylic acid cycle (TCA or Krebs cycle) is classically regarded as a pathway for glucose oxidation. However, the experiments by Le and the team show that B cells oxidize glutamine when glucose is absent.
The study also found that when oxygen is scarce, there is enhanced conversion of glutamine to glutathione, an important agent for controlling the accumulation of oxygen-containing chemically reactive molecules that cause damage to normal cells.
When the investigators used a glutaminase inhibitor, cancerous growth of B cells was stopped in petri dishes.
"The flexibility of the TCA cycle in using both glutamine and glucose pathways may be important for cancer cells to proliferate and survive, especially under the low-oxygen and nutrient-deprived conditions often encountered in the tumor microenvironment, " says Le.
Now, perhaps, scientists can exploit that survival strategy to stop cancer, according to former Johns Hopkins scientist Chi Dang, M. D. , now at the Abramson Cancer Center at the University of Pennsylvania. "A broader and deeper understanding of cancer cell metabolism and cancer cells'ability to reprogram biochemical pathways under metabolic stress can be a rich ground for therapeutic approaches targeting tumor metabolism, " he says.
In addition to Le, an assistant professor in the Department of Pathology at the Johns Hopkins University School of Medicine, other researchers from Johns Hopkins who participated in this study include Sminu Bose, Arvin Gouw, Joseph Barbi, Takashi Tsukamoto, Camilo J. Rojas and Barbara Slusher. The Johns Hopkins Brain Science Institute, where Tsukamoto, Rojas and Slusher are faculty, is pursuing the development of new glutaminase inhibitor drugs.
Below is the latest cancer update from the WHO (World Health Organization). Please pay attention to the 'key facts' section. The last bullet says this:
"It is expected that annual cancer cases will rise from 14 million in 2012 to 22 within the next two decades."
Not only will cancer cases rise, the fact that cancer will still not have a cure from the allopathic medical field is even more sad. When will this stop? Probably NEVER because they don't want a cure! Here's the article link: http://www.who.int/mediacentre/factsheets/fs297/en/index.html
The cancer cure discovered by the 12 doctors this molecule GcMAF universal cure for cancer and was treating autism and whole long list of other illnesses. The doctor made some other very shocking discoveries regarding vaccines. Sadly, all the doctors that were doing this research were all killed. GcMAF is being offered in advanced nations, However, you can guarantee that it will not be offered here to us homeboys!
HI U HOMEBOY,,,,,,,,,,,,,,, you right on the money with this conclusion. These doctors used the Nagalase test to determine if you have any cancer at all. We sent our blood test to Holland and learned that my tractor driver was good to go, but I was over 2, so I did have cancer. But how was I to treat it as you elude.
I'm not telling you anything new, but our medical folks are corrupt to the core. It's a money thing. That is the reason that I welcome a violet revolution. We need it and may the best folks win.
=======ORH=========
Got ATS to tell you, but you will have to wait 6 months on this one. I got another serious health problem and have elected to go the natural way. It's a goodie and I kinda scared, but I got a program and it will be thumbs up or thumbs down. At 76, I have lived a full life and am going out with dignity one way or the other.
Ya'll behave for a change. ==ROBERT HENRY====
Hi Lisa from Idaho - Kelley Eidem, the author who wrote The Doctor Who Cures Cancer, has a YouTube video on using SinusBuster for cancer pain. SinusBuster is a cayenne spray used for sinus problems and headaches. You can buy it at any health food store or even some supermarket pharmacies.
Here's the page with the information: http://kelleyeidem.hubpages.com/hub/cancerpain
The article is entitled: Can Cancer Pain Be Wiped Out with a Nasal Spray? The video is near the end of the article. The sound and picture isn't the best but there is good information in it as well as in the article. The comment section is a must read (scroll past the ads). People are writing in saying what worked for their cancer pain.
It seems alkalizing the body is a key component.
Best of luck to you and your son. Take care, Bess
Hi Lisa, You May check this link for cancer protocol with natural way. Kellly Eidem runs hubb pages you can seek his help for your son'c cure
Hope this will help you. Many good wishes for your son's recovery.
Yo Redneck Buddy == ROBERT HENRY=====
Hi Robert, It is a great news, about the marker to detect cancer as well as a protocol to eliminate it. Can you please provide a link so everyone else can read and learn more what is current in cancer treatment.
I sincerely hope that your test results will come out to your liking. Good Luck and God Bless.
But I have also read about chloroquine (anti malarial drug) which is now under clinical trials, as it inhibits autophagy.
My question do you think it is possible to combine both treatments in an attempt to starve the cancer?
Get this book "How I Cured My Stage Four Multi-Organ Cancer" By William Truck. He used black salve and yellow salve to pull it up to the surface of the skin in what is called an eschar. Then the eschar is removed much as a scab. It left a huge scar. But if he had applied a plantain poultice, or even honey it would have healed without scaring. Soak plantain leaf in olive oil over night. Apply to skin. Allow to stay until leaf dries up. Then replace continually until sore heals. if bandaid is needed only use gauze and make it big, two pieces overlapping about one half inch to cover wound. Then when leaf dries just part the gauze and insert new leaf.
I did this for my husband's brown recluse bite. Three days completely healed no scar. Plantain very powerful, but don't know that it is as powerful as the salve. Expect a lot of pain as the salve does it's job with removing the tumor if you have a cancer. Truck's book says some don't have that much pain because their cancers are much smaller.
Carba, There's nothing more deadly to enzymes than acidic body (which also harbors cancer). Purchase PH strips and use sodium bicarbonate (baking soda) orally to get your PH slightly alkaline. Ted recommends bicarb and ACV effective for alkalizing. For immediate and powerful relief, take a very warm bath with 1/2 cup sodium bicarbonate and 1/2 cup epsom salt for at least 30 min.
Also, the numerous glands in the human body produce hormones & enzymes, so during illness or in aging, the glands lose some degree of function. Consume as directed herbal gland cleanser/stimulator, raw multiglandular, and digestive/systemic enzymes.
Knowing many friends and relatives with different types of cancers, I want to be able to help with alternatives to chemo and radiation. Even if they choose to go with chemo and radiation, and you certainly can't blame them when they're fighting for their lives, perhaps there are some alternative therapies that help the process.
Of course, there are some legitimate alternative treatments out there. Please reply with the very best alternative treatments you know of, especially if you've witnessed the treatment's success for yourself.
There have to be some treatments that, when applied together, do much better than a singular treatment. There are also different cancers that may be better treated with one type of treatment versus another.
I've listed some treatments I've heard about:
Essiac tea, Budwig Protocol, Hydrogen Peroxide, Antioxidants, Mega doses of Vitamin C, detoxing, Omega 3 and other Omegas, Ozone therapy, group prayer, energy healing, Acupuncture, Tesla Coil, hot springs bathing, sulphur springs bathing, oil pulling, hyperbaric chamber, Coconut Oil, Coenzyme Q-10, Ubiquinone.
Please share your thoughts on promising individual treatments and combinations.
Thank you.
Hope4friends, I may be reiterating some recent post but I personaly believe that the use of Magnets or hemotite stones is critical in cancer theropy. My theory is that of all the conventional and alternative cancer theropies that do not work, they all have, ultimately an homogenous cause, and energy modalities should be used Firstly in order to remove the negative energy, inflammation, acidification, and god knows how many more "ations".
Some specialist are finding Near-Infared Light Theropy (topical or sauna) very helpful in detox & healing.
Also I have personaly witnessed good results with Leonard Horrowitze's theoretical Solffagio Harmonics. The 528 "Love" vibration supposedly the same vibration that is God's heartbeat is especially encouraged as it heals and reprograms damaged DNA. Also, I have only done a few of the Carlos Castaneda Tensegrity movements, but I do notice some slight immediate resuts especially the "Helping The Flow Of Immunity" (minor movement). Tensegrity is available in book or DVD format. Yoga and Meditation, yes.
Also, it seems rather obvious that Liver Support is critical in beating cancer as the Liver is such a vital organ. Colon and Gallbladder cleanses are, in turn, critical for Liver health (i know, I found out that hard way).
Lastly, CoQ10 or ubiguinone gets most of the rave in cellular energy and oxygenation, but I wouldn't rely on it alone. Also use the coenzymes Alpha Lipoic Acid and NADH.
Lastly again, there is much studies recommending the body's need for Methylation. Suppliment with the fallowing methyl donors vit-b12, Folic Acid, SAM-e, Betaine, DMG.
Several years ago a customer came into the store and told me his wife was diagnosed with breast cancer 30 years ago. He declined surgery, radiation, and chemo and opted for alternative. He doesn't know which worked, but he started her on three things: flaxseed oil in cottage cheese, shark cartilidge, and apricot pits (seeds) from the cannery. They are bitter to the taste. (They contains cianide but there are good cianides and bad ones. This kind kills the bad cells and doesn't hurt the good ones. ) She lived without problems (and smoked on the side) for those 30 years. She died after suffering with Alzheimer's for a few years during which time he continued to care for her. He died at 96 and ate apricot pits (seeds) regularly. Hope this helps someone else.
These 3 therapies are focusing on boosting the bodies immune response and except for LDN should be able to boost the other chosen therapies.. (consult your doctor naturally... and do as much research as possible...)
1. LDN... Low dose naltrexone... one of many links http://www.youtube.com/watch?v=DAZ1fQKdOC8
2. Beta Glucans such as AHCC... http://ahccresearch.com/
3. IP6-Inositol http://jn.nutrition.org/content/133/11/3778S.full
TimH, Would you please explain why lima beans, peaches & almonds in a daily diet can help fight cancer or help boost LDN? Thank you
Http://www.ldndatabase.com/ourstory/
Please read the story of Jacinta and John and the protocol they developed to overcome Jacinta's very serious cancer diagnosis. It is not the same cancer as you describe but some of the protocol may also work for you, too. Jacinta has been well for 38 months now.
Connie, you should watch this video on cancer and iodine deficiency.
great info.. Thanks Love... It is the nature of any great momentum, in this case the cancer drug industry, that it is incredibly resistant to anything other than its continued direction...
So..its been many years, and the article has since been been removed from the Mercola site. If you or anyone can recall the points, and would love to share, it would be appreciated. Since Ted has not been around, there've been many changes. Excellent posts, tried and proven true, cures that worked and ideas have been removed. And many people have taken physical notes over the years, of cure that are not here anymore. Its not the "neighborhood health and prayer center" anymore. I was one of the email prayer partners, all that was cut off. My prayer today, is that for you the one who is searching for a cure, to be filled with Godly wisdom, to be led to that cure.
EC: Not true. Very few posts on Earth Clinic have been removed over the years. However, if you are using a mobile device, switch to VIEW FULL VERSION in the main menu, and you will access the full site. Or use a desktop computer, which is the best way to view all the content on the site.
Mobile users on Earth Clinic are redirected to a fast-loading mini-site specifically designed for mobile devices unless they choose the View Full Version option. Since 2014.
I found that The Camelot Cancer Care in Tulsa, Oklahoma has been recommended by many. They do treatments that are intravenous DMSO-based.
You may also want to check with Frank Cousineau with the Cancer Control Society (CCS) who, among other things, organizes tours to alternative cancer clinics in Tijuana, Mexico several times a year.
I attended the CCS convention last year and was very impressed.
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